A5013739924- Immunodeficiency and Autoimmune Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Blood disorders and treatments
- Autoimmune Bullous Skin Diseases
- Global Cancer Incidence and Screening
- Cystic Fibrosis Research Advances
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Lung Cancer Treatments and Mutations
- Pneumocystis jirovecii pneumonia detection and treatment
- Dermatology and Skin Diseases
- Platelet Disorders and Treatments
- Lung Cancer Diagnosis and Treatment
- Pharmacovigilance and Adverse Drug Reactions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mast cells and histamine
- Empathy and Medical Education
- Pleural and Pulmonary Diseases
- Celiac Disease Research and Management
- Otitis Media and Relapsing Polychondritis
- Vitamin K Research Studies
- Congenital Ear and Nasal Anomalies
- Complementary and Alternative Medicine Studies
Necmettin Erbakan University
2023-2025
Izmir University
2018
Ege University
2013-2015
Backround: Rapid drug desensitization (RDD) is commonly used for immediate hypersensitivity reactions (DHR) across various drugs. In delayed DHRs, the conventional approach slow desensitization; however, limitations may arise due to drug-specific or disease-related factors. With increasing role of targeted molecular drugs in data on efficacy RDD these contexts remain scarce. Objective: This case series aims explore rationale and outcomes managing DHRs associated with therapies. Methods: We...
Background: Studies on the impact of comorbidities treatment responses in severe eosinophilic asthma (SEA) are limited. This study was a real-world investigation into how presence or absence nasal polyps (NP) and sensitivity to aeroallergens influence outcomes mepolizumab therapy. Methods: In this retrospective study, data obtained from patients with SEA who received at least 6 months were analyzed. The initially divided two groups based NPs. Within these groups, further categorized...
Background: Selective immunoglobulin E deficiency (sIgED) is a rare condition characterized by low serum IgE levels with normal of other classes. The prevalence sIgED varies considerably across populations, higher observed in clinical settings. Studies report that ranges up to 9.7% patients attending rheumatology clinics, 8.1% allergy/immunology and 2.6% healthy blood donors. Its role immune regulation association autoimmune autoinflammatory disorders remains poorly understood. Objective:...
Background: Omalizumab is a preferred treatment in antihistamine-refractory chronic spontaneous urticaria (CSU) patients. However, factors that may impact response remain to be explored. Objective: This study aimed examine the affecting CSU patients receiving omalizumab. Methods: was retrospective included 123 who received omalizumab for between January 2015 and April 2024. After administering omalizumab, we evaluated therapeutic efficacy with control test (UCT). According UCT, were...
Abstract Background/Aims: Hereditary angioedema (HAE) is a rare genetic disorder (prevalence approximately 1:50,000) marked by recurrent episodes of severe swelling due to deficiency in the C1 inhibitor (C1-INH) protein, affecting complement and contact systems. This study aims evaluate impact Prognostic Nutritional Index (PNI) on clinical outcomes HAE patients. Methods: A single-center retrospective cohort 60 patients was analyzed. Clinical characteristics PNI were assessed, calculated...
Primary immunodeficiency diseases (PIDs) show different patterns of airway involvement, particularly bronchiectasis; however, comparative studies radiologic manifestations in patients with PIDs are scarce. Hence, the aim this study to investigate lung findings adult and evaluate possible relationship between clinical immunologic features respiratory function these patients. In study, demographic characteristics, serum immunoglobulins (Ig), lymphocyte subgroups, high-resolution computed...
Background: The main treatment of common variable immunodeficiency (CVID) is to maintain immunoglobulin G (IgG) levels within the target range. However, trough IgG differ among patients with similar body mass index (BMI) and those receiving same dose replacement therapy (IGRT). A crucial factor that underlies these differences presence extensive bronchiectasis, which associated salvage pathway. Objective: We compared in CVID without bronchiectasis who had received IGRT for 2 years determine...
Background: Autoimmune diseases can occur at any time in patients with common variable immunodeficiency (CVID). However, the relationship between low immunoglobulin E (IgE) levels and autoimmune CVID remains poorly understood. Objective: We aimed to determine autoimmunity IgE CVID. Methods: This retrospective cohort study was conducted by using data that had been collected from 62 adult April 2012 December 2021. Serum basal were compared without disease. Results: Overall, 23 of (37.1%) least...
We aimed to obtain information about the characteristics of ICUs in our country via a point prevalence study.
AMA Evcen R, Çölkesen F, Aykan et al. Awareness of hereditary angioedema among emergency physicians: a survey study. Alergologia Polska - Polish Journal Allergology. 2024. doi:10.5114/pja.2024.135506. APA Evcen, R., Çölkesen, F., Aykan, Kılınç, M., Yıldız, E., & Ergün, Ü. (2024). https://doi.org/10.5114/pja.2024.135506 Chicago Recep, Fatih Filiz Sadi Mehmet Eray Ümmügülsüm Yılmaz and Tuğba Önalan "Awareness study". Harvard Ü., Önalan, T., Kahraman, S., Gerek, Arslan, Ş. MLA Recep study."...
Background: This study analyzes the immune system parameters of intern doctors working actively during COVID-19 pandemic. When an doctor failed to respond treatment a severe condition, panel was examined and as result, it revealed underlying immunodeficiency. The death caused several concerns among other doctors, for this reason, their systems were also considered be examined. aims demonstrate that immunodeficiencies might more common than is known general population. Methods: In...
<b><i>Introduction:</i></b> The use of medications in older adults is increasing due to the prevalence chronic diseases. Data on characteristics drug allergies (DAs) are limited. This study investigated and clinical DAs patients aged 65 years older. <b><i>Methods:</i></b> Patient records were examined retrospectively between January 2018 December 2022. included 200 ≥18 who met criteria for diagnosis type B reactions. divided into two groups:...
Objective: Hereditary angioedema (HAE) is characterized by attacks of subcutaneous and mucosal edema. HAE usually affects the skin or tissues upper respiratory gastrointestinal tract. Irritable bowel syndrome (IBS) one diseases in which abdominal symptoms may be confused. In this study, we aimed to clarify role IBS clinical presentation diagnostic delay HAE. Material Method: 50 patients with followed our clinic between January 2013 April 2023 were included hospital records retrospectively...
Although separate immunogenic mechanisms are involved, IgE-type sensitization to wheat and celiac disease (CD) may coexist. We observationally assessed the importance of this relationship in daily practice using CD screenings.
Amaç: Çalışmamızın amacı; idiyopatik pulmoner fibrozisli (IPF) hastaların seri solunum fonksiyon testi (SFT) ölçüm parametrelerinin prognozu öngörmedeki değerini retrospektif olarak gözlemlemektir. İkincil ise yaş, cinsiyet, sigara öyküsü, sistolik arter basıncı (SPAB) yüksekliği gibi diğer değişkenlerle prognoz ve SFT parametreleri arasındaki ilişkiyi saptamaktır. Gereç Yöntem: Çalışmaya dahil edilen 94 olgunun demografik verileri yanısıra ilk başvurudaki izlemdeki (6.ay, 12.ay, 24.ay,...
Background: Selective immunoglobulin E deficiency (sIgED) is a rare immunological condition characterized by low serum IgE levels while maintaining normal of other classes. Despite its underrecognized nature, sIgED has been implicated in immune dysregulation, potentially predisposing individuals to autoimmune and autoinflammatory diseases. Objective: This study aims investigate the association between immune-mediated diseases, exploring prevalence, clinical implications, underlying...
Common variable immunodeficiency (CVID) is the most common symptomatic in adults. This study assessed utility of using C-reactive protein (CRP)/albumin ratio (CAR) at diagnosis to predict mortality CVID patients. Between 2010 and 2022, hospital records follow-up cards patients with were reviewed retrospectively. Seventy-five included study. CRP 0–5 mg/L albumin 3.5–5.5 g/dL taken as references. The CAR was obtained by dividing value value. Of patients, 41 (55%) male 34 (35%) female. median...