A5038280955- Immunotherapy and Immune Responses
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- vaccines and immunoinformatics approaches
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- SARS-CoV-2 and COVID-19 Research
- Mass Spectrometry Techniques and Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammatory mediators and NSAID effects
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- Cancer Research and Treatments
- Bladder and Urothelial Cancer Treatments
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Sleep and Wakefulness Research
- RNA Interference and Gene Delivery
- Seaweed-derived Bioactive Compounds
- Antioxidant Activity and Oxidative Stress
- NF-κB Signaling Pathways
Iran University of Medical Sciences
2013-2024
Tehran University of Medical Sciences
2008-2020
Children's Medical Center
2020
Innate immune cells play a crucial role in bone development and repair. Macrophages are the main effector responses to implants indispensable for healing success. The heterogeneity plasticity of macrophages make them prime target system modulation enhance repair regeneration. It is believed that polarization macrophage phenotype towards anti-inflammatory M2, rather than inflammatory M1 phenotype, promotes osteogenesis. Tissue-engineered bioimplants potentially capable producing signals...
Prostate cancer is one of the most widespread cancers in world. Early diagnosis important factor treatment efficiency. Furthermore, new methods for early and play an role. In this study, we designed targeted conjugation antibodies with iron nanoparticles evaluated binding properties to prostate benign tissues. This method addition having a lower cost has high sensitivity specificity.Anti- PSCA were purified conjugated super magnetic oxide (SPION). Then, staining on adenocarcinoma tissues was...
Targeting inhibitory receptors on T cells in the tumor sites can promote effective anti-tumor immunity bladder cancer. Unfortunately, main dilemma is that a large number of patients remain refractory to CTLA-4, PD-1, and PD-L1 blockade therapies. T-cell immunoglobulin mucin domain 3 (Tim-3) an receptor expressed innate immune cells. Both vivo vitro data from with advanced cancers support role Tim-3 inhibition satisfactory immunity. In cancer, expression level significantly increases...
Melanoma antigen gene (MAGE)-A6 and MAGE-A11 are two of the most cancer-testis antigens overexpressed in various types cancers. However, clinical prognosis value MAGE-A6 co-expression pathophysiology bladder is unknown. Three studies were selected from GEO databases order to introduce common genes that involved cancer. Then immunohistochemical analysis for staining pattern clinicopathological significance suggested markers, MAGE-A11, performed 199 213 paraffin-embedded cancer with long...
Melanoma antigen gene-A2 (MAGE-A2) is one of the most cancer-testis antigens overexpressed in a variety malignancies. However, expression MAGE-A2 for clinical values pathophysiology renal cell carcinoma (RCC) unknown. For first time, present study was conducted to examine and prognostic significance clear RCC (ccRCC). assayed 162 well-defined ccRCC samples using immunohistochemistry staining on tissue microarrays. The association between clinic-pathologic features as well survival outcomes...
The aim of this study was to produce a novel polyclonal antibody against extracellular domain NGEP protein and explore its role in prognosis prostate cancer. Polyclonal antibodies two peptides (NGEP-p1 NGEP-p2) derived domains were prepared the intensity distribution expression analyzed large series tissue specimens. We found significant inverse correlation between prognostic features such as Gleason score, pathologic tumor stage prostate-specific antigen level using anti-NGEP-p2 antibody....