A5064849411- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Cerebrovascular and Carotid Artery Diseases
- Coronary Interventions and Diagnostics
- Additive Manufacturing and 3D Printing Technologies
- Polymer Foaming and Composites
- Advanced Sensor and Energy Harvesting Materials
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Health and Disease Prevention
- Photonic and Optical Devices
- Cardiac Valve Diseases and Treatments
- Photonic Crystals and Applications
- Cellular and Composite Structures
- Graphene and Nanomaterials Applications
- Orthopaedic implants and arthroplasty
- MRI in cancer diagnosis
- Pelvic floor disorders treatments
- biodegradable polymer synthesis and properties
- Advanced MRI Techniques and Applications
- Hernia repair and management
- Cardiac Imaging and Diagnostics
- Medical Imaging Techniques and Applications
- Optical Coatings and Gratings
- Pelvic and Acetabular Injuries
- Elasticity and Material Modeling
Aarhus University
2015-2025
Smith College
2018
Syracuse University
2018
University of Memphis
2018
Texas A&M University
2018
John Wiley & Sons (United States)
2018
Aarhus School of Architecture
2011
Aarhus University Hospital
2010
University of Washington
2010
Center for NanoScience
2010
Abstract The peripheral immune system is important in neurodegenerative diseases, both protecting and inflaming the brain, but underlying mechanisms remain elusive. Alzheimer’s Disease commonly preceded by a prodromal period. Here, we report presence of large Aβ aggregates plasma from patients with mild cognitive impairment ( n = 38). are associated low level Disease-like brain pathology as observed 11 C-PiB PET 18 F-FTP lowered CD18-rich monocytes. We characterize complement receptor 4...
Abstract The binding of Abs to microbial surfaces followed by complement activation constitutes an important line defense against infections. In this study, we have investigated the relationship between and human IgM with different curvatures. dextran were shown activate potently on dextran-coated particles having a diameter around 250 nm, whereas larger (600 nm) less potent activators. This selectivity regarding particle dimension was also found for colloidal substances origin....
Electrospinning has been widely applied for tissue engineering due to its versatility of fabricating extracellular matrix (ECM) mimicking fibrillar scaffolds. Yet there are still challenges such as that these two-dimensional (2D) tightly packed, hydrophobic fibers often hinder cell infiltration and cell-scaffold integration. In this study, polycaprolactone (PCL) was electrospun into a grounded coagulation bath collector, resulting in 3D coiled microfibers with situ surface functionalization...
Abstract A porcine calvaria defect study was carried out to investigate the bone repair potential of three‐dimensional (3D)‐printed poly‐ε‐caprolactone (PCL) scaffolds embedded with nanoporous PCL. microscopic grid network created by rapid prototyping making a 3D‐fused deposition model (FDM‐PCL). Afterward, FDM‐PCL were infused mixture PCL, water, and 1,4‐dioxane underwent thermal‐induced phase separation (TIPS) followed lyophilization. The TIPS process lead structure shielded printed...
The creation of complex tissues and organs is the ultimate goal in tissue engineering. Engineered morphogenesis necessitates spatially controlled development multiple cell types within a scaffold implant. We present novel method to achieve this by adhering nanoparticles containing different small-interfering RNAs (siRNAs) into nanostructured scaffolds. This allows spatial retention nanopores until their cellular delivery. released siRNAs were capable gene silencing BCL2L2 TRIB2, mesenchymal...
Abstract: Bone tissue engineering implants with sustained local drug delivery provide an opportunity for better postoperative care bone tumor patients because these offer release at the site and reduce systemic side effects. A rapid prototyped macroporous polycaprolactone scaffold was embedded a porous matrix composed of chitosan, nanoclay, β-tricalcium phosphate by freeze-drying. This composite evaluated on its ability to deliver anthracycline antibiotic promote formation mineralized in...
Abstract We studied the osteoconductive tissue response of hydroxyapatite (HA) nanoparticles functionalized with osteopontin (OPN) in a matrix poly‐ D,L ‐lactic‐acid (PDLLA). In canine endosseus 0.75‐mm gap implant model, we tested osteointegrative impact OPN composite as an coating, and non‐functionalized was used reference control. During four weeks observation, coating significantly increased formation new bone porosities implant, but no differences were observed gap. The study provides...
Abstract The left atrium (LA) hemodynamic indices hold prognostic value in various cardiac diseases and disorders. To understand the mechanisms of these conditions to assess performance devices interventions, vitro models can be used replicate complex physiological interplay between pulmonary veins, LA, ventricle. In this study, a comprehensive adaptable model was created. includes flexible LA made from silicone allows distinct control over systolic diastolic functions both mechanically...
Abstract Surgical outcome following pelvic organ prolapse (POP) repair needs improvement. We suggest a new approach based on tissue‐engineering strategy. In vivo, the regenerative potential of an electrospun biodegradable polycaprolactone (PCL) mesh was studied. Six different PCL meshes were evaluated in full‐thickness abdominal wall defect model 84 rats. The rats assigned into three groups: (1) hollow fiber delivering two dosages basic fibroblast growth factor (bFGF), (2) solid with and...
Abstract Pelvic organ prolapse (POP) affects many women, with an estimated lifetime risk of surgical intervention 18.7%. There is a need for alternative approaches as the use synthetic nondegradable mesh was stopped due to severe adverse events, and current methods pelvic floor repair have high POP recurrence rates. Thus, we hypothesized that electrospun degradable meshes stem cells growth factor were safe durable long term in elderly rats. In abdominal model, polycaprolactone (PCL) coated...
Muscle atrophy is a well-known consequence of immobilization and critical illness, leading to prolonged rehabilitation increased mortality. In this study, we develop solution preserve muscle mass using customized biocompatible neuromuscular electrical stimulation (NMES) device. Commercially available NMES solutions with gel-based electrodes often lead skin irritation. We demonstrate the printing conducting on compressive stocking textile that can be used for more than seven days without...
Printed electronics has enabled fabrication of electronic components and devices with low cost more manufacturing design freedom. This technique been successfully employed as a complementary approach to conventional nanolithography microfabrication processes create flexible stretchable electronics. Fluoropolymers are crucial in components, owing their piezoelectric, triboelectric, pyroelectric, ferroelectric, dielectric properties. In this research, we report an inkjet-printed piezoelectric...
Abstract It is well established in the field of biomaterials that hydroxyapatite (HA) may provide interesting osteoconductive properties. In this study, we investigated osseointegrational effect a 50/50 vol % composite HA nanoparticles and poly‐ D , L ‐lactic acid (PDLLA) coated on model titanium bone implants an vivo animal model. The aim to evaluate how addition PDLLA improve formation initial fixation implant. Two with PDLLA/HA pure PDLLA, respectively, were implanted bilaterally proximal...
Successful application of advanced engineered materials in osteoplasty requires a biological understanding the recipient reaction. The immune system acts like double-edged sword by maintaining targeted tissue and rejecting grafts. Nevertheless, even for promising graft such as polycaprolactone, insights on contact with cells have been restricted due to lacking quantitative assays. Here, we show that polycaprolactone sites after cranioplasty are dominated an immature type multinucleated giant...
In the field of tissue engineering, integration micro-porosity, nano-topogaphical features and weattability into one three-dimensional (3D) scaffold remains a challenge. The extracellular matrix (ECM) mimicking feature electrospun fibers endows them wide applications in engineering. However, tight-packing submicron hinder cell infiltration further colonization. this study, we fabricated hydrophilic, micro-porous scaffolds with nano-topographical cues by one-step electrospinning, investigated...
Stomach-related disorders impose medical challenges and are associated with significant social economic costs. The field of biomechanics is promising for understanding tissue behavior development treatments surgical interventions. In gastroenterology, animal models often used when studies on humans not possible. Often large similar anatomical characteristics (size shape) preferred. However, it uncertain if stomachs from animals have mechanical properties. aim the present study to...
Mechanical stress may contribute to plaque rupture in patients with carotid atherosclerosis. We determined longitudinal mechanical stresses atherosclerotic plaques and compared them known markers of vulnerability.Nineteen symptomatic scheduled for endarterectomy underwent MRI a multicontrast protocol characterize morphology geometry. Longitudinal 2-dimensional computational models were generated from the data, calculated.Peak occurred predominantly shoulder regions correlated inversely...
Abstract Additive manufacturing is a promising technique in tissue engineering, as it enables truly individualized implants to be made fit particular defect. As previously shown, feasible strategy produce complex multicellular tissues deposit different small interfering RNA (siRNA) porous that are subsequently sutured together. In this study, an additive carbohydrate hydrogels containing siRNAs applied into implant, spatially controlled manner. When the obtained structures seeded with...
Electrospun fabrics for use in, example, tissue engineering, wound dressings, textiles, filters and membranes have attracted a lot of attention due to their morphological nanoscale architectures which enhance physical properties. A thorough detailed internal study has been performed on electrospun polystyrene (PS) fibers produced from dimethylformamide (DMF) solutions. Investigations by transmission electron microscopy (TEM) studies the first time synchrotron based X-ray tomographic (XTM)...