A5062601268- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neurological Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Electromagnetic Fields and Biological Effects
- Nuclear Receptors and Signaling
- Neurological Disorders and Treatments
- Protein Degradation and Inhibitors
- Global trade and economics
- Acupuncture Treatment Research Studies
- Biofield Effects and Biophysics
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Global Energy Security and Policy
- International Business and FDI
- Barrier Structure and Function Studies
- Tryptophan and brain disorders
- Natural Resources and Economic Development
Lillebaelt Hospital
2022-2024
Vejle Sygehus
2024
Aarhus University Hospital
2017-2022
Aarhus University
2017-2020
University of Southern Denmark
2007
The aim of this longitudinal study was to assess with positron emission tomography (PET) the relationship between levels inflammation and loads aggregated β-amyloid tau at baseline again after 2 years in prodromal Alzheimer's disease.Forty-three subjects mild cognitive impairment (MCI) had serial 11C-PK11195 PET over measure changes, 11C-PiB determine fibril load; 22 also 18F-Flortaucipir tangle load. Cortical surface statistical mapping used localise areas showing significant changes tracer...
See Kreisl (doi:10.1093/awx151) for a scientific commentary on this article.Subjects with mild cognitive impairment associated cortical amyloid-β have greatly increased risk of progressing to Alzheimer's disease. We hypothesized that neuroinflammation occurs early in disease and would be present most amyloid-positive cases. 11C-Pittsburgh compound B 11C-(R)-PK11195 positron emission tomography was used determine the amyloid load detect extent (microglial activation) 42 Twelve age-matched...
Abstract Previous studies have reported substantial involvement of the noradrenergic system in Parkinson’s disease. Neuromelanin-sensitive MRI sequences and PET tracers become available to visualize cell bodies locus coeruleus density terminal transporters. Combining these methods, we investigated relationship neurodegeneration distinct compartments We examined 93 subjects (40 healthy controls 53 disease patients) with neuromelanin-sensitive turbo spin-echo calculated coeruleus-to-pons...
Abstract The peripheral immune system is important in neurodegenerative diseases, both protecting and inflaming the brain, but underlying mechanisms remain elusive. Alzheimer’s Disease commonly preceded by a prodromal period. Here, we report presence of large Aβ aggregates plasma from patients with mild cognitive impairment ( n = 38). are associated low level Disease-like brain pathology as observed 11 C-PiB PET 18 F-FTP lowered CD18-rich monocytes. We characterize complement receptor 4...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder. AD pathology characterized by abnormal aggregation of the proteins amyloid-β (Aβ) and hyperphosphorylated tau. No effective modifying therapies are currently available. A short-duration intervention with 40 Hz light flicker has been shown to reduce brain Aβ load in transgenic mice. We aimed test effect similar regime human patients. utilized Light Emitting Diode (LED) bulb flicker. Six positive patients received 10 days...
Background: Alzheimer's disease copathology is common in PD at autopsy. In non-PD subjects with mild cognitive impairment, tau depositions can be detected using 18F-AV-1451 PET. We hypothesized that PET would show aggregation impairment and correlate dysfunction. Objectives: To describe patients. Methods: Twenty-six patients 23 controls had neuropsychological assessment to detect impairment. Results: Nine (35%) were identified Regional analyses showed no significant differences between...
Hippocampus-associated genes that orchestrate the formation of compact stratum pyramidale are largely unknown. The BTB (broad complex, tramtrack,bric-a-brac)-zinc finger gene Zbtb20 (also known as HOF, Znf288,Zfp288) encodes two protein isoforms, designated Zbtb20S and Zbtb20L, which expressed in newborn pyramidal neurons presumptive hippocampus mice. Here, we have generated transgenic mice with ectopic expression Zbtb20L immature differentiated from multipotent non-hippocampal precursors....
Alterations in cerebral perfusion is increasingly considered to play a crucial role Alzheimer's disease (AD) and together with accumulated amyloid-β, deficiencies the brain microvascular circulation may result local hypoxia. Here, we studied alterations correlation between amyloid-β load prodromal AD (pAD). Using dynamic susceptibility contrast MRI PET, evaluated levels 19 individuals mild cognitive impairment (MCI) high (pAD-MCI), 13 MCI without pathology 21 healthy controls. The pAD-MCI...
Introduction Cardiovascular disease increases the risk of developing Alzheimer's (AD), and growing evidence suggests an involvement cerebrovascular pathology in AD. Capillary dysfunction, a condition which capillary flow disturbances rather than arterial blood supply limit brain oxygen extraction, could represent overlooked vascular contributor to neurodegeneration. We examined whether cortical transit-time heterogeneity (CTH), index is elevated amyloid-positive patients with mild cognitive...
Abstract Background Plasma and cerebrospinal fluid levels of neurofilament light (NfL), a marker axonal degeneration, have previously been reported to be raised in patients with clinically diagnosed Alzheimer’s disease (AD). Activated microglia, an intrinsic inflammatory response brain lesions, are also known present majority Alzheimer or mild cognitive impaired (MCI) subjects β-amyloid load on their positron emission tomography (PET) imaging. It is now considered that the earliest phase...
Cardiovascular risk factors are associated with the development of Alzheimer's disease (AD), and increasing evidence suggests that cerebral microvascular dysfunction plays a vital role in progression. Using magnetic resonance imaging, we investigated two-year changes blood flow 11 mild cognitively impaired (MCI) patients prodromal AD compared to 12 MCI without 10 intact age-matched controls. The pAD-MCI displayed widespread deterioration perfusion capillary dysfunction. No such were observed...
Noradrenergic neurotransmission may play an important role in tremor modulation through its innervation of key structures the central circuits. Here, Parkinson's disease (PD) patients with (PDT+) or without (PDT-) rest had 11C-methylreboxetine(11C-MeNER) positron emission tomography (PET) to test hypothesis that noradrenaline terminal function was relatively preserved PDT+ compared PDT-. Sixty-five PD and 28 healthy controls (HC) were scanned 11C-MeNER PET. Patients categorized as if...
Abstract INTRODUCTION Microglial responses are an integral part of Alzheimer's disease (AD) pathology and associated with amyloid beta (Aβ) deposition. This study aimed to investigate the effects Aβ microglial on global cognitive impairment. METHODS In this longitudinal study, 28 patients mild impairment 11 healthy controls underwent C‐PK11195 C‐Pittsburgh compound B positron emission tomography (PET), structural magnetic resonance imaging scans, ratings at baseline 2‐year follow‐up....
Abstract INTRODUCTION Capillary dysfunction, characterized by disturbances in capillary blood flow distribution, might be an overlooked factor the development of Alzheimer's disease (AD). This study investigated microvascular preclinical and prodromal AD individuals. METHODS Using dynamic susceptibility contrast magnetic resonance imaging positron emission tomography, we examined alterations circulation levels Aβ deposition two independent cohorts APOE ε 4 carriers. RESULTS dysfunction was...
The typical spatial pattern of amyloid-β (Aβ) in diagnosed Alzheimer's disease (AD) is that a symmetrical hemispheric distribution. However, Aβ may be asymmetrically distributed early stages AD. distribution on PET has previously been explored MCI and AD, but it yet to directly investigated preclinical AD (pAD). We examined how was individuals with pAD using 11C-Pittsburgh Compound B (PiB) PET.In this study, 79 subjects were retrospectively enrolled, including 34 controls, 24 pAD, 21 MCI....
ABSTRACT BACKGROUND AND PURPOSE In vivo detection of β‐amyloid (Aβ) plaques in Alzheimer's disease (AD) is now possible with 11 C‐PiB positron emission tomography (PET). Conventionally, a cortical:cerebellar PiB uptake ratio threshold 1.4‐1.5 has been used to categorize at‐risk subjects as “amyloid‐positive” and “amyloid‐negative.” It suggested that this too conservative may miss early amyloid pathology. We investigated the relationship between conventional lower baseline PET thresholds for...
Flortaucipir PET, a marker of tau tangles, has shown lower than expected cortical uptake in Parkinson's disease (PD), would be predicted from neuropathologic estimates Alzheimer's co-pathology. Instead, the most characteristic finding flortaucipir imaging PD is decreased substantia nigra, reflecting reduction its "off-target" binding to neuromelanin. We have previously reported these observations cross-sectional studies.Here, we present two-year follow-up data and nigral patients.Seventeen...
Abstract The pathophysiological development of Alzheimer's disease (AD) begins in the brain years before onset clinical symptoms. accumulation beta‐amyloid (Aβ) is thought to be first cortical pathology occur. Carrying one apolipoprotein E ( APOE ) ε4 allele increases risk developing AD at least 2–3 times and associated with earlier Aβ accumulation. Although it difficult identify Aβ‐related cognitive impairment early standard tests, more sensitive memory tests may able do this. We sought...
Alzheimer’s disease is characterised by plaques of β-amyloid in the cerebral cortex, however, mechanisms leading to accumulation and downstream neurodegeneration remain elusive. Alterations perfusion increasingly considered play a crucial role together with accumulated β-amyloid, deficiencies brain microvascular circulation may result local hypoxia. Here, we studied correlation between changes individuals mild cognitive impairment (MCI) elevated levels cortical β-amyloid.Using MRI PET,...