April Camilla Roslani
A5030689194- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 and healthcare impacts
- Anorectal Disease Treatments and Outcomes
- Global Health and Surgery
- Cancer survivorship and care
- Diverticular Disease and Complications
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Global Cancer Incidence and Screening
- Pelvic floor disorders treatments
- Appendicitis Diagnosis and Management
- Trauma and Emergency Care Studies
- Hernia repair and management
- Gut microbiota and health
- Stoma care and complications
- Minimally Invasive Surgical Techniques
- Surgical site infection prevention
- Cancer Research and Treatments
- Diversity and Career in Medicine
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
University of Malaya
2016-2025
University Malaya Medical Centre
2014-2024
University of Birmingham
2022-2023
National University of Avellaneda
2023
ESCP Business School
2023
ESCP Business School
2023
NIHR Birmingham Biomedical Research Centre
2023
University of Göttingen
2022
National Institute for Health Research
2022
Institut de Virologie
2020-2021
Significance We demonstrate, to our knowledge for the first time, that bacterial biofilms are associated with colorectal cancers, one of leading malignancies in United States and abroad. Colon biofilms, dense communities bacteria encased a likely complex matrix contact colon epithelial cells, nearly universal on right tumors. Most remarkably, biofilm presence correlates tissue invasion changes biology enhanced cellular proliferation, basic feature oncogenic transformation occurring even...
Colorectal cancer (CRC) remains the third most common worldwide, with a growing incidence among young adults. Multiple studies have presented associations between gut microbiome and CRC, suggesting link risk. Although CRC continue to profile larger patient cohorts increasingly economical rapid DNA sequencing platforms, few been identified, in part due limitations taxonomic resolution differences analysis methodologies. Complementing these is newly recognized phenomenon that bacterial...
IL17-producing Th17 cells, generated through a STAT3-dependent mechanism, have been shown to promote carcinogenesis in many systems, including microbe-driven colon cancer. Additional sources of IL17, such as γδ T become available under inflammatory conditions, but their contributions cancer development are unclear. In this study, we modeled Th17-driven tumorigenesis by colonizing Min(Ap) (c+/-) mice with the human gut bacterium, enterotoxigenic Bacteroides fragilis (ETBF), investigate link...
Escherichia coli (E. coli) from the B2 phylogenetic group is implicated in colorectal cancer (CRC) as it possesses a genomic island, termed polyketide synthetase (pks), which codes for synthesis of colibactin, genotoxin that induces DNA damage, cell cycle arrest, mutations and chromosomal instability eukaryotic cells. The aim this study was to detect compare prevalence E. expressing pks (pks+ CRC patients healthy controls followed by investigating virulence triggered pks+ using an in-vitro...
The 2015 Lancet Commission on global surgery identified and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility planned surgical services around world, which have also been neglected in pandemic recovery planning. This study aimed to develop validate a novel index support local elective system strengthening address growing backlogs.
Surgical site infection (SSI) remains a common postoperative morbidity, particularly in colorectal resections, and poses significant financial burden to the healthcare system. The omission of mechanical bowel preparation, as is performed enhanced recovery after surgery programmes, appears further increase incidence. Various wound protection methods have been devised reduce incidence SSIs. However, there are few randomized controlled trials assessing their efficacy. aim this study investigate...
Colorectal cancer is the third most commonly diagnosed malignancy and fourth leading cause of cancer-related death globally. It second common among both males females in Malaysia. The economic burden colorectal likely to increase over time owing its current trend aging population. Cancer survival analysis an essential indicator for early detection improvement treatment. However, there was a scarcity studies concerning patients as well predictors. Therefore, we aimed determine 1-, 3- 5-year...
Abstract Background Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in availability of laparoscopic appendectomy, alternative management choices, outcomes are poorly described. The aim was to identify variation appendicitis within low-, middle-, high-Human Development Index (HDI) countries Methods This a multicenter, international prospective cohort study. Consecutive sampling patients undergoing appendectomy over 6...
This study aimed to determine the impact of pulmonary complications on death after surgery both before and during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.
Lemur tyrosine kinase 3 (LMTK3) is an oncogenic that involved in different types of cancer (breast, lung, gastric, colorectal) and biological processes including proliferation, invasion, migration, chromatin remodeling as well innate acquired endocrine resistance. However, the role LMTK3 response to cytotoxic chemotherapy has not been investigated thus far. Using both 2D 3D tissue culture models, we found overexpression decreased sensitivity breast cell lines (doxorubicin) treatment. In a...
This study aimed to estimate the cost of colorectal cancer (CRC) management and explore prevalence determinants catastrophic health expenditure (CHE) among CRC patients their families arising from costs management. Data were collected prospectively 138 patients. Patients interviewed by using a structured questionnaire at time diagnosis, then 6 months 12 following diagnosis. Simple descriptive methods multivariate binary logistic regression used in analysis. The mean managing was RM8306.9...
Abstract Fusobacterium nucleatum is an oral bacterium known to colonize colorectal tumors, where it thought play important role in cancer progression. Recent advances sequencing and phenotyping of F. have revealed differences at the subspecies level, but whether these impact overall tumor ecology, tumorigenesis itself, remain poorly understood. In this study, we sought characterize Fusobacteria microbiome a cohort individuals with CRC through combination molecular, spatial, microbiologic...
Recent advances in microRNAome have made microRNAs (miRNAs) a compelling novel class of biomarker cancer biology. In the present study, role miR-23a carcinogenesis colorectal (CRC) was investigated. Cell viability, apoptosis, and caspase 3/7 activation analyses were conducted to determine potentiality apoptosis resistance function CRC. Luciferase assay performed verify putative target site 3'-UTR protease activating factor 1 (APAF1) mRNA. The expression levels APAF1 CRC cell lines (SW480...
Colorectal cancer is the second most common in Malaysia. The prognosis of disease excellent if detected at an early stage, but majority Malaysian patients present late stages. We aimed to assess awareness warning signs and anticipated delay help-seeking as possible contributors this phenomenon.A population-based cross-sectional survey using Cancer Awareness Measure was initiated Perak, A total 2,379 respondents aged 18 years above were recruited a multi-stage sampling five locations....
BackgroundEnd colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation end after left-sided resection.