A5029368729- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Cell Adhesion Molecules Research
- Bone and Joint Diseases
- Inflammatory mediators and NSAID effects
- Intestinal Malrotation and Obstruction Disorders
- Abdominal vascular conditions and treatments
- Transplantation: Methods and Outcomes
- Anesthesia and Pain Management
- Circular RNAs in diseases
- Hip disorders and treatments
- Intestinal and Peritoneal Adhesions
- RNA modifications and cancer
- Spine and Intervertebral Disc Pathology
- Chemokine receptors and signaling
- Pain Management and Opioid Use
University of Birmingham
2019-2023
Versus Arthritis
2022
Abstract Background Osteoarthritis (OA), a multifaceted condition, poses significant challenge for the successful clinical development of therapeutics due to heterogeneity. However, classifying molecular endotypes OA pathogenesis could provide invaluable phenotype‐directed routes stratifying subgroups patients targeted therapeutics, leading greater chances success in trials. This study establishes soft joint tissue driven by obesity both load‐bearing and non‐load bearing joints. Methods...
Changes in cellular metabolism have been implicated mediating the activated fibroblast phenotype a number of chronic inflammatory disorders, including pulmonary fibrosis, renal disease and rheumatoid arthritis. The aim this study was therefore to characterise metabolic profile synovial joint fluid fibroblasts under both basal conditions cohort obese normal-weight hip OA patients. Furthermore, we sought ascertain whether modulation pathway could alter their activity. Synovium obtained from...
Metastasis Associated Lung Adenocarcinoma Transcript-1 (MALAT1) is implicated in regulating the inflammatory response and pathology of several chronic diseases, including osteoarthritis (OA). The purpose this study was to examine relationship between OA subchondral bone expression MALAT1 with parameters joint health biomarkers inflammation, determine its functional role human osteoblasts. Subchondral blood were collected from hip knee patients (n = 17) only neck femur fracture 6) undergoing...