A5044159827- Tuberculosis Research and Epidemiology
- Vector-borne infectious diseases
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Signaling Pathways in Disease
- Mycobacterium research and diagnosis
- Bacterial Genetics and Biotechnology
- Esophageal Cancer Research and Treatment
- Ion channel regulation and function
- Inhalation and Respiratory Drug Delivery
- Yersinia bacterium, plague, ectoparasites research
- Calcium signaling and nucleotide metabolism
- COVID-19 and healthcare impacts
- Toxin Mechanisms and Immunotoxins
- Clostridium difficile and Clostridium perfringens research
- Cancer Immunotherapy and Biomarkers
Foundation Medicine (United States)
2023
University of Alabama at Birmingham
2013-2015
Mahidol University
2013-2014
Iron is an essential nutrient for most bacterial pathogens, but restricted by the host immune system. Mycobacterium tuberculosis (Mtb) utilizes two classes of small molecules, mycobactins and carboxymycobactins, to capture iron from human host. Here, we show that Mtb mutant lacking mmpS4 mmpS5 genes did not grow under low conditions. A cytoplasmic reporter indicated double experienced starvation even high-iron Loss change uptake carboxymycobactin Mtb. Thin layer chromatography showed...
The ability to control the timing and mode of host cell death plays a pivotal role in microbial infections. Many bacteria use toxins kill cells evade immune responses. Such are unknown Mycobacterium tuberculosis. Virulent M. tuberculosis strains induce necrotic macrophages by an obscure molecular mechanism. Here we show that protein Rv3903c (channel with necrosis-inducing toxin, CpnT) consists N-terminal channel domain is used for uptake nutrients across outer membrane secreted toxic...
An engorged female Amblyomma helvolum Koch tick was removed from an adult Varanus salvator Laurenti lizard during field collection in Thailand. After using polymerase chain reaction to amplify three genes (16S rDNA, gltA, and OmpA), we discovered the presence of a Rickettsia sp. Spotted Fever Group. Phylogenetic analysis revealed that this is closely related raoultii Mediannikov. Therefore, report herein for first time detection novel Group
e15141 Background: PD-L1 and TMB are the most widely used immunotherapy biomarkers to identify populations who would benefit from immunotherapy, with higher values predicting better therapeutic efficacy. We sought explore occurrence correlation of these two in a community based cancer center patient population rural central Nebraska. Methods: One hundred sixty consecutive patients(pts) diagnosed treated between 2018-2022 at Morrison Cancer Center were evaluated. Malignant tumor tissue...