A5022437661- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Liver Disease Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Erythropoietin and Anemia Treatment
- Cardiovascular Function and Risk Factors
- Potassium and Related Disorders
- Viral Infections and Immunology Research
- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Coronary Artery Anomalies
- Folate and B Vitamins Research
- Medical Imaging and Pathology Studies
- Trace Elements in Health
- Radiation Dose and Imaging
- Cardiovascular Disease and Adiposity
- Hepatitis C virus research
- Cerebrovascular and Carotid Artery Diseases
- Vascular Anomalies and Treatments
- Parvovirus B19 Infection Studies
- Mycobacterium research and diagnosis
- Vascular anomalies and interventions
- Sarcoidosis and Beryllium Toxicity Research
Azienda Unità Sanitaria Locale di Ferrara
2009-2024
Delta Air Lines (United States)
2022-2024
Délégation Provence et Corse
2021
University of Ferrara
2000-2020
Arcispedale Sant'Anna
2017-2019
Lithuanian University of Health Sciences
2016
Centro Hospitalar de Vila Nova de Gaia
2016
Azienda Ospedaliero-Universitaria Careggi
1998-2003
We systematically explored the link of pancreatic iron with glucose metabolism and cardiac complications in a cohort 1,079 patients thalassemia major (TM) enrolled Extension-Myocardial Iron Overload Thalassemia (E-MIOT) project.MRI was used to quantify overload (T2* technique) function (cine images) detect macroscopic myocardial fibrosis (late gadolinium enhancement technique). Glucose assessed by oral tolerance test (OGTT).Patients normal showed significantly higher global pancreas T2*...
Abstract Aims A tailored chelation therapy guided by magnetic resonance imaging (MRI) is a strategy to improve the prognosis in iron-loaded patients, many cases still hampered limited MRI availability. In order address this issue, Myocardial Iron Overload Thalassemia (MIOT) network was established Italy and we aimed describe impact of 10-year activity on cardiac burden thalassemia major (TM). Methods results Within MIOT network, 1746 TM patients (911 females; mean age 31.2 ± 9.1 years) were...
In transfusion-dependent thalassemia patients who started regular transfusions in early childhood, we prospectively and longitudinally evaluated the efficacy on pancreatic iron of a combined deferiprone (DFP) + desferrioxamine (DFO) regimen versus either oral chelator as monotherapy over follow-up 18 months.
We assessed the prognostic value of multiparametric cardiovascular magnetic resonance (CMR) in predicting death from heart failure (HF) thalassemia major (TM). considered 1398 white TM patients (30.8 ± 8.9 years, 725 women) without a history HF at baseline CMR, which was performed within Myocardial Iron Overload Thalassemia (MIOT) network. overload quantified by using T2* technique, and biventricular function determined with cine images. Late gadolinium enhancement (LGE) images were acquired...
The management of patients affected by lung cancer requires the expertise specialists from different disciplines. Although advantages multidisciplinary team discussions seem obvious, there are limited studies evaluating influence this approach on postoperative outcomes in non-small-cell (NSCLC). aim study is to examine impact a survival undergoing surgery for NSCLC. A retrospective analysis was performed consecutive who underwent NSCLC between January 2008 and December 2015. Data were...
Background Cardiac MRI plays a critical role in the management of thalassemic patients. No accurate biventricular reference values are available. Purpose To establish ranges for normal left ventricular (LV) and right (RV) volumes ejection fraction (EF) LV mass normalized to body surface area (BSA), age, gender large cohort well‐treated beta‐thalassemia major (β‐TM) patients without heart damage using multiparametric MRI. Study Type Retrospective/cohort study. Population In all, 251 β‐TM with...
Summary We prospectively assessed the efficacy of deferasirox versus deferiprone or desferrioxamine as monotherapy in thalassaemia major (TM) patients by magnetic resonance imaging (MRI). selected enrolled Myocardial Iron Overload Thalassaemia network who received only one chelator between two MRIs (deferasirox = 235, 142, 162). overload was measured T2* technique and biventricular function cine images. Among with baseline myocardial iron, all three groups there a significant improvement...
High-Resolution MRI of Carotid Plaque With a Neurovascular Coil and Contrast-Enhanced MR Angiography: One-Stop Shopping for the Comprehensive Assessment AtherosclerosisStefano Tartari1, Roberto Rizzati1, Riccardo Righi1, Anna Deledda1, Katia Capello2, Soverini3 Giorgio Benea1Audio Available | Share
In thalassemia major, pancreatic iron was demonstrated as a powerful predictor not only for the alterations of glucose metabolism but also cardiac iron, fibrosis, and complications, supporting profound link between heart disease. We determined first time prevalence overload (IO) in intermedia (TI) systematically explored pancreas T2* values outcomes. considered 221 beta-TI patients (53.2% females, 42.95 ± 13.74 years) consecutively enrolled Extension-Myocardial Iron Overload Thalassemia...
Cardiac involvement in sickle beta thalassemia (Sβ-thal) patients has been poorly investigated. We aimed to evaluate cardiac function and myocardial iron overload by cardiovascular magnetic resonance (CMR) with Sβ-thal. One-hundred eleven Sβ-thal consecutively enrolled the Myocardial Iron Overload Thalassemia (MIOT) network were studied compared 46 cell anemia (SCA) 111 gender- age- matched healthy volunteers. Cine images acquired quantify biventricular function. (MIO) was assessed T2*...
ST-segment elevation MI (STEMI) is a rare presentation in patients with coronary artery anomalies. In these patients, the identification of culprit lesion and its treatment may be difficult, particularly emergency setting primary percutaneous intervention (PCI). From January 2008 to April 2011, 1015 STEMI received angiography PCI our centre. Of these, 5 (0.4%) showed anomaly. this paper we reported two cases: i) first single originating from right sinus Valsalva; ii) second separate origin 3...
Summary We longitudinally evaluated the effects of regular blood transfusions (BTs), in real‐life context Myocardial Iron Overload Thalassaemia network, patients with thalassaemia intermedia (TI). considered 88 TI (52 females) who started BTs after age 18 years. Magnetic resonance imaging was used to quantify iron overload and biventricular function. For 56·8% there were more than two indications for transition BTs, anaemia present 94·0% cases. A significant decrease nucleated red cells,...
We prospectively evaluated in thalassemia major (TM) patients the changes pancreatic iron levels assessed by T2* magnetic resonance imaging (MRI), their dependence on total body balance, and association with different chelators monotherapy. Among overload (IO) at baseline MRI, only 5.2% showed no IO follow-up performed 18 months later. The 29.5% of without IO, MRI. reduction was inversely correlated directly serum ferritin hepatic iron. baseline, all three groups treated monotherapy...
We present a rare case of anomalous origin the left coronary artery from pulmonary syndrome in an elderly man, and we describe computed tomographic angiographic imaging findings to improve diagnostic confidence for evaluation this uncommon anomaly.A 70-year-old Caucasian man came our hospital with slight limitation physical activity (New York Heart Association class II). He was asymptomatic angina, syncope, palpitations. Cardiac magnetic resonance performed after echocardiography because...
We evaluated the impact of genotype on hepatic, pancreatic and myocardial iron content, cardiac endocrine complications in children with transfusion-dependent β-thalassemia (β-TDT). considered 68 β-TDT patients (11.98 ± 3.67 years, 51.5% females) consecutively enrolled Extension-Myocardial Iron Overload Thalassemia network. overload was quantified by T2* technique biventricular function cine images. Replacement fibrosis late gadolinium enhancement technique. Three groups were identified:...
Abstract Background In pediatric transfusion‐dependent thalassemia (TDT) patients, we evaluated the prevalence, pattern, and clinical associations of pancreatic siderosis changes in iron levels their association with baseline total body balance. Procedure We considered 86 TDT patients consecutively enrolled Extension‐Myocardial Iron Overload Thalassemia Network. overload (IO) was quantified by R2* magnetic resonance imaging (MRI). Results Sixty‐three (73%) had IO (R2* > 38 Hz). Global...
We prospectively evaluated the predictive value of multiparametric cardiac magnetic resonance (CMR) for cardiovascular complications in non-transfusion-dependent β-thalassemia (β-NTDT) patients who started regular transfusions late childhood/adulthood (neo β-TDT).
The aim of this article was to illustrate a case primary septic arthritis the manubriosternal joint, due Staphylococcus aureus infection, in an immunocompetent 28-year-old male patient. joint can be rarely involved inflammatory processes, but pyarthrosis is even more unusual otherwise healthy adult. Although rare, could associated with significant morbidity and mortality, first all because spreading mediastinal structures. Diagnosis generally made thanks imaging findings after clinical...