Reactive oxygen species (ROS) and cellular oxidant stress have long been associated with cancer. Unfortunately, the role of HClO in tumor biology is much less clear than for other ROS. Herein, we report a BODIPY-based probe (BClO) ultrasensitivity, fast response (within 1 s), high selectivity, which pyrrole group at meso position has an "enhanced PET" effect on BODIPY fluorophore. The detection limit as low 0.56 nM, highest sensitivity achieved to date. BClO can be facilely synthesized by...

Rlyso, a highly selective and sensitive pH sensor, can stain lysosomes with novel lysosome-locating group, methylcarbitol. Rlyso was successfully used to detect lysosomal changes during apoptosis or induced by chloroquine while avoiding the "alkalizing effect" on of current probes nitrogen-containing sidechains.

We report a low-temperature (150 °C) and simple synthesis of quasi-monodispersed uniform hexagonal (Wurtzite) ZnS nanocrystals in ethylene glycol medium. The samples structures were characterized with X-ray diffraction technique transmission electron microscopy. It is believed that medium plays key role forming which stable phase at high temperatures.

A memory effect has been demonstrated in magnetic nanowire arrays. The array the ability to record maximum field that exposed after turned off. origin of is strong dipole interaction among nanowires. Switching distributions nanowires studied with a first-order reversal curve technique elucidate discrepancy between experimental result and theoretical explanation. Based on effect, novel extremely low cost EMP detection scheme proposed.

Abstract Cellular viscosity is a critical factor in governing diffusion‐mediated cellular processes and linked to number of diseases pathologies. Fluorescent molecular rotors (FMRs) have recently been developed determine solutions or biological fluid. Herein, we report “distorted‐BODIPY”‐based probe BV‐1 for viscosity, which different from the conventional “pure rotors”. In , internal steric hindrance between meso ‐CHO group 1,7‐dimethyl forced boron–dipyrrin framework be distorted, mainly...

The magnetic and electrical properties of crystalline Mn0.05Si0.95 films prepared by post-thermal treatment the as-deposited amorphous Si-Mn (95at.%−5at.%) have been investigated. Both temperature dependence field magnetization were measured using superconducting quantum interference devices, it has indicated that film materials are ferromagnetic with Curie over 400K. X-ray diffraction analysis revealed full crystallization incorporation Mn into host Si lattice. Behavior thermally activated...

Abstract Because palladium is widely used in various catalysts and converters, which results a high level of contamination water systems the soil by residual palladium, there an urgent need for Pd 2+ ‐sensitive ‐selective probes. Based on special affinity to conjugated double‐bond ligands, two fluorescence probes ( RPd2 RPd3 ) that contain allylidene‐hydrazone ligands link colorless rhodamine‐spirolactam have been developed. The show allylidene‐hydrazones much better toward , consequently...

A novel fluorescence resonance energy transfer (FRET)-based probe, γ-cyclodextrin modified oleic acid–NaYF4:Yb, Ho upconversion nanoparticles functionalized with a rhodamine B derivative (RBD), has been achieved for Fe3+-sensing in aqueous solution high sensitivity and selectivity.

For the first time, we have synthesized orthorhombic phase KSc2F7:20%Yb/2%Er (KSc2F7:Yb/Er) nanorods and further studied crystal structure morphology evolution, as well their upconversion (UC) properties under varying F− contents reaction temperatures. Different from β-NaYF4:20%Yb/2%Er (NaYF4:Yb/Er) that usually give strong green UC luminescence, red emission was observed in KSc2F7:Yb/Er 980 nm laser excitation. Their mechanisms are analyzed compared. This study provides a novel type of rare...

The first Golgi-localized cyclooxygenase-2 (COX-2)-specific near-infrared (NIR) fluorescent probe, Niblue-C6-IMC, able to detect cancer cells, was designed. Importantly, Niblue-C6-IMC preferentially labeled the tumors in a mouse tumor model with deep tissue penetration capacity. It may be promising molecular tool for guiding resection during surgery.

An aza-coumarin based fluorescent and colorimetric AC-ClO for the ClO − determination with fast response high sensitivity. was successfully applied live-cell imaging of exogenous endogenous .

Zinc dyshomeostasis is a major mechanism of neuronal death, which involved in many different neuropathological conditions. Lysosomal membrane permeabilisation has an important function zinc-induced death under oxidative stress. To investigate lysosomal zinc functions neurons with high spatial and temporal reliability, we report ratiometric probe, LysoZn-1. It derived from the styryl-BODIPY-DPA scaffold lysosome-targeted 2-morpholinoethylamine moiety to allow localisation lysosomes. The...

Hypochlorous acid (HClO), one of the reactive oxygen species (ROS), is a key microbicidal agent which used for natural defense; however, it also involved in several human diseases. Although efforts have been made to develop HClO-selective fluorescent sensors, most them display delayed response time and ratiometric sensors are rare. In current work, we 3-pyrrole BODIPY dye as new sensor (BRClO) HClO. BRClO exhibited 177-fold fluorescence ratio (F505 nm/F585 nm) enhancement presence HClO over...

In this work, we report a phenomenon that upconversion emission intensity of Er3+ was enhanced by cadmium. Cd2+ taken with 0, 3, 10, 20, 30, and 40 mol % as new dopant to codope LiY0.78Yb0.20Er0.02F4, meanwhile the doping effects on crystal structure, morphology, fluorescence are investigated XRD, Rietveld refinement, TEM, spectroscopy analysis methods in detail. The green enhanced, maximum intensities were twice when 10 codoped into tetragonal LiYF4, while its decay lifetime reduced....

Magnetic materials with tunable ferromagnetic resonant (FMR) frequencies are highly desirable in microwave devices. In this manuscript, we demonstrate that the natural FMR of Ni90Fe10 nanowire array can be tuned continuously from 8.2 to 11.7 GHz by choosing different remanent states. Theoretical model based on magnetostatic interaction among nanowires has been developed explain observed phenomena.

We have demonstrated that the bound magnetic polaron model is responsible for ferromagnetism in Co–ZnO semiconductors, where carriers are provided by interstitial zinc (Zn i ). Our experiment unique since changing temperature, we able to cross carrier concentration threshold above which a long-range ferromagnetic order established. Consequently, observed at room temperature but weakened temperatures below 100 K. To support our conclusion performed systematic investigation on structural, and...

, a Nile Blue based NIR fluorescent dye was reported. is highly effective in specifically labeling lysosomes with low concentration and good photostability various kinds of live cells. It first successfully used to observe the disappearance reproduction during cell division.

Abstract Polarity-sensitive fluorescent probes are powerful chemical tools for studying biomolecular structures and activities both in vitro vivo . However, the lack of “off-on” polarity-sensing has limited accurate monitoring biological processes that involve an increase local hydrophilicity. Here, we design synthesize a series polarity-sensitive BP consisting difluoroboron dippyomethene (BODIPY) fluorophore connected to quaternary ammonium moiety via different carbon linkers. All these...

A novel upconversion fluorescent resonant energy transfer biosensor was fabricated for Hepatitis B virus DNA hybridization detection.