A5052827007- Cardiovascular Function and Risk Factors
- Chemotherapy-induced cardiotoxicity and mitigation
- Heart Failure Treatment and Management
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Nitric Oxide and Endothelin Effects
- Adipose Tissue and Metabolism
- Cancer Treatment and Pharmacology
- Acute Myocardial Infarction Research
- Cardiac Health and Mental Health
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Galectins and Cancer Biology
- Cardiac Arrest and Resuscitation
- Mitochondrial Function and Pathology
- Cancer-related cognitive impairment studies
- TGF-β signaling in diseases
- Cardiac Fibrosis and Remodeling
- Aortic Disease and Treatment Approaches
- Cardiovascular Disease and Adiposity
- Cardiac Arrhythmias and Treatments
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac Ischemia and Reperfusion
- Infective Endocarditis Diagnosis and Management
- Cardiac electrophysiology and arrhythmias
Hunter Medical Research Institute
2017-2025
Hunter New England Local Health District
2017-2025
University of Newcastle Australia
2017-2025
John Hunter Hospital
2017-2025
Calvary Mater Newcastle Hospital
2020-2024
Liverpool Hospital
2024
Princess Alexandra Hospital
2024
The University of Adelaide
2009-2023
Queen Elizabeth Hospital
2009-2023
Basil Hetzel Institute
2009-2023
Background Mitochondrial reactive oxygen species ( ROS ) are associated with metabolic heart disease MHD ). However, the mechanism by which cause is unknown. We tested hypothesis that mitochondrial a key mediator of . Methods and Results Mice fed high‐fat high‐sucrose HFHS diet develop cardiac diastolic dysfunction oxidative posttranslational modifications proteins. Transgenic mice express catalase in mitochondria wild‐type were an or control for 4 months. Cardiac from ‐fed had 3‐fold...
<h3>Objective</h3> Tako-Tsubo cardiomyopathy (TTC) is associated with regional left ventricular dysfunction, independent of the presence fixed coronary artery disease. Previous studies have used T2-weighted cardiac MRI to demonstrate periapical oedema. The authors sought determine distribution, resolution and correlates oedema in TTC. <h3>Patients</h3> 32 patients TTC were evaluated at a median 2 days after presentation, along 10 age-matched female controls. Extent was quantified both...
Highlights•High energy phosphates were measured in the hearts of mice with metabolic heart disease (MHD).•The rate myocardial ATP synthesis was decreased MHD.•The free hydrolysis energetic changes MHD are associated pump dysfunction.•The pattern differs qualitatively from dilated cardiomyopathy.AbstractMetabolic syndrome is a cluster obesity-related abnormalities that lead to (MHD) left ventricular dysfunction. Although thought be deficiency, two key questions have not been answered. First,...
Abstract Background and Aims The detection of cancer therapy-related cardiac dysfunction (CTRCD) by reduction left ventricular ejection fraction (LVEF) during chemotherapy usually triggers the initiation cardioprotective therapy. This study addressed whether same approach should be applied to patients with worsening global longitudinal strain (GLS) without attaining thresholds LVEF. Methods Strain surveillance for improving cardiovascular outcomes (SUCCOUR-MRI) was a prospective multicentre...
Abstract Background and Aims Current guidelines recommend 6 hours of solid food 2 clear liquid fasting for patients undergoing cardiac procedures with conscious sedation. There are no data to support this practice, previous single centre studies the safety removing requirements. The objective study was determine non-inferiority a strategy prior catheterisation which require Methods This is multicentre, investigator-initiated, randomised trial conduced in Australia prospective open label...
Abstract Background Clozapine has demonstrated superiority in improving both positive and negative symptoms of treatment‐resistant schizophrenia; however, there are associated treatment‐limiting side effects, including myocarditis, cardiomyopathy agranulocytosis. Aim This retrospective cohort study describes the prevalence left ventricular (LV) dysfunction, cardiovascular risk factors outcomes a patients maintained on clozapine therapy. Methods Data were retrospectively collated from who had...
Background Impaired generation and signaling of nitric oxide ( NO) contribute substantially to cardiovascular CV ) risk CVR associated with hypertension, hyperlipidemia, diabetes mellitus. In our rapidly aging society, advanced age is, in itself, a consistent independent factor. Many processes involved are modulated by NO . We therefore postulated that might be independently impaired signaling. Methods Results prospective cohort study 204 subjects (mean 63±6 at entry), we evaluated the...
Aging promotes a range of degenerative pathologies characterized by progressive losses tissue and/or cellular function. Fibrosis is the hardening, overgrowth and scarring various tissues accumulation extracellular matrix components. an important predisposing factor common for fibrotic heart respiratory disease. Age-related processes such as senescence, inflammaging, autophagy mitochondrial dysfunction are interconnected biological that diminish regenerative capacity aged lung have been shown...
This consensus statement of Australian clinicians provides new recommendations for the pharmacological management heart failure based on studies reported since publication 2018 guidelines.▪Use sodium-glucose cotransporter 2 (SGLT2) inhibitors to prevent hospitalisation in type diabetes mellitus can be extended patients with multiple cardiovascular risk factors, albuminuric chronic kidney disease, or atherosclerotic disease. ▪New evidence supports use a mineralocorticoid receptor antagonist...
Cancer and cardiovascular disease (CVD) commonly coexist, with increasing evidence that long-term cancer survivors are more likely to die from CVD than the general population. Effective management of its risk factors requires identification patients at increased who may benefit early intervention their appropriate monitoring across trajectory. Improving outcomes new models multidisciplinary care supported by pathways. Such pathways require a clear delineation roles responsibilities all team...