Assessing fibrosis risk noninvasively is essential. The steatosis-associated estimator (SAFE) score shows promise but needs validation.

Low dose radiation may stimulate the growth and development of animals, increase life span, enhance fertility, downgrade incidence tumor occurrence.The aim this study was to investigate antitumor effect hormesis in an erythrocyte system induced by low-dose radiation.Kunming strain male mice were subcutaneously implanted with S180 sarcoma cells right inguen as experimental situ animal model. Six hours before implantation, given 75mGy whole body X-ray radiation. Tumor observed 5 days later,...

Liver stiffness measurements (LSMs) are promising for monitoring disease progression or regression. We assessed the prognostic significance of dynamic changes in LSM over time on liver-related events (LREs) and death patients with chronic hepatitis B (CHB) compensated advanced liver (cACLD).

Emerging research indicates that individuals with non-alcoholic fatty liver disease (NAFLD) who carry excess weight have similar or even higher survival rates than their normal-weight counterparts. This puzzling "obesity paradox" may be attributed to underlying biases. To explore this phenomenon, we examined data extracted from the third National Health and Nutrition Examination Survey (NHANES) III, which spanned 1988-1994. We specifically targeted participants diagnosed NAFLD through...

Adipogenesis of adipocytes includes two stages: initiation and maturation. Growth hormone (GH) secretion is decreased in obese subjects GH levels are inversely correlated with abdominal fat mass. The effects growth on lipids accumulation or maturation remains elusive.In the present study, effect lipid vitro vivo was examined. cDNA microarray, quantitative real time-PCR (qPCR) western blotting used to analyze expression genes related adipocyte degradation pre- mature 3T3-F442A treated...

The optimal treatment strategy for early-stage hepatocellular carcinoma (HCC) remains controversial, specifically in regard to surgical resection (SR) and ablation. aim of this study was investigate the impact SR ablation on recurrence prognosis HCC patients, optimize strategies improve long-term survival.

Despite proton pump inhibitors (PPIs) being generally safe, there are questions about their potential long-term complications. The present study aimed to investigate the association between PPI therapy and incidence of hepatic steatosis liver fibrosis in outpatient population United States. included 7,395 individuals aged ≥20 years who underwent vibration-controlled transient elastography (VCTE) examination. data were obtained from January 2017 March 2020 pre-pandemic National Health...

The clinical and histological features of chronic hepatitis B (CHB) patients who fall into the "grey zone (GZ)" do not fit conventional natural phases are unclear.To explore impact varying threshold alanine aminotransferase (ALT) levels in identifying significant liver injury among GZ patients.This retrospective analysis involved a cohort 1617 adult diagnosed with CHB underwent biopsy. were determined based on European Association for Study Liver 2017 Clinical Practice Guidelines. classified...

Objective: To compare the clinical effects of concurrent radiochemotherapy with those radiotherapy in treating locally advanced nasopharyngeal carcinoma (Stage III~IVa). Methods: A total 95 patients suffering from III~IVa) were divided into two groups: (Group CCRT, n=49) and RT, n=46). The groups both delivered conventional fractionated radiotherapy, while Group CCRT also received three cycles PF (DDP+5-Fu) or PLF (DDP+5-Fu+CF) chemotherapy. Results: complete remission rate higher than RT...

To the Editor: Liver cirrhosis (LC), end-stage condition of chronic liver disease, results in >1,300,000 annual deaths worldwide. Meanwhile, global incidence decompensated is rising yearly.1 Following clinically significant portal hypertension (CSPH) late compensated stage LC, as disease progresses to stage, ascites, gastroesophageal variceal bleeding, hepatic encephalopathy (HE), and other severe complications present. Nonselective beta-blockers (NSBBs) have currently served first-line...

Hepatitis B virus (HBV) infection is a major public health issue worldwide as it may cause serious liver diseases such cirrhosis and hepatocellular carcinoma (HCC). Ruling out important when treating chronic hepatitis (CHB). The aim of this study was to compare the performance aspartate aminotransferase-to-platelet ratio index (APRI), fibrosis score based on four factors (FIB-4), red cell volume distribution width-to-platelet (RPR) in diagnosing stages identify new cut-off values rule...

In the present study, left anterior descending coronary arteries of mice under anesthesia were ligated, and optimal surgical conditions for artery ligation (CAL) in establishment a myocardial infarction (MI) mouse model investigated. All that survived sacrificed seven days subsequent to successful surgery. Body weight, blood serum heart tissues obtained further analysis or biochemical histopathological examinations. The survival rate following CAL procedure was 70%. aspartate...

<h3>Background</h3> Emerging research indicates that individuals carrying excess weight experience similar or even higher survival rates in non-alcoholic fatty liver disease (NAFLD) compared to their normal-weight counterparts. This puzzling 'obesity paradox' might be attributed underlying biases. To delve into this phenomenon, we examined data extracted from the third National Health and Nutrition Examination Survey (NHANES) III spanning 1988-1994. <h3>Methods</h3> We specifically targeted...

<h3>Background</h3> Liver stiffness measurement (LSM) holds promise in monitoring disease progression or regression. We aim to assess the prognostic significance of dynamic changes LSM over time concerning liver-related events (LREs) and death patients with chronic hepatitis B (CHB) compensated advanced liver (cACLD). <h3>Methods</h3> This retrospective study included 1272 CHB cACLD who underwent at least twice measurement, including fibrosis score based on four factors (FIB-4)...

Background There is a paucity of data on whether steatosis impacts autoimmune hepatitis (AIH) treatment response. We aimed to evaluate the influence baseline biochemical response, fibrosis progression, and adverse longterm outcomes AIH. Methods Steatosis was diagnosed by controlled attenuation parameter (CAP) ≥ 248 dB / m. Only patients who underwent immunosuppressive therapy with available liver histological material at diagnosis qualified CAP within seven days biopsy were included....

<h3>Background</h3> In chronic hepatitis B patients, an indeterminate phase exists outside the typical predefined phases. Our study investigates this phase's natural history and prognosis, focusing on antiviral treatment outcomes. <h3>Methods</h3> We conducted a retrospective cohort to compare risk of transitioning Immune Active in patients with incidence adverse liver outcomes (hepatocellular carcinoma and/or cirrhosis) between untreated (at baseline throughout follow-up) those who received...