A5002289102- Nuclear Physics and Applications
- Nuclear reactor physics and engineering
- Boron Compounds in Chemistry
- Heat transfer and supercritical fluids
- Particle accelerators and beam dynamics
- Boron and Carbon Nanomaterials Research
- Radiation Therapy and Dosimetry
- Nuclear Materials and Properties
- Radiopharmaceutical Chemistry and Applications
- Nuclear Engineering Thermal-Hydraulics
- Superconducting Materials and Applications
- Spacecraft and Cryogenic Technologies
- Fusion materials and technologies
- Particle physics theoretical and experimental studies
- Atomic and Subatomic Physics Research
- Mosquito-borne diseases and control
- Graphite, nuclear technology, radiation studies
- Thermochemical Biomass Conversion Processes
- Heat Transfer and Boiling Studies
- Rocket and propulsion systems research
- Radiation Detection and Scintillator Technologies
- Neutrino Physics Research
- Magnetic confinement fusion research
- Thermodynamic and Structural Properties of Metals and Alloys
- Combustion and flame dynamics
China Spallation Neutron Source
2014-2025
Spallation Neutron Source
2025
Institute of High Energy Physics
2011-2025
Chinese Academy of Sciences
2011-2025
University of Chinese Academy of Sciences
2024
Harbin Institute of Technology
2016-2023
Xi’an International University
2017
Accurate prediction of the relative biological effectiveness (RBE) boron neutron capture therapy (BNCT) is challenging. The different from other radiotherapy; dynamic distribution boron-containing compounds in tumor cells affects therapeutic outcome considerably and hampers accurate measurement neutron-absorbed dose. Herein, we used metal-organic framework nanoparticles (BMOFs) with high content to target U87-MG maintain concentration 10B isotope cells. could 90% (60 ppm) within 20 min...
A neutronics/thermal‐hydraulics (TH) coupled spatial dynamics code, reactor system transient analysis‐three dimensional (RESTA‐3D), has been developed for both static and analysis of large advanced light water reactors (LWRs), with a focus on control rod (CR) ejection accidents. The code is based neutron diffusion model, employing the widely used “two‐step” strategy in 3D Cartesian coordinates. polynomial nodal expansion method (NEM) to handle variables, while kinetics solver applies...
The development of boron-containing carbon quantum dots for boron neutron capture therapy (BNCT) offers a promising strategy treating refractory tumors. We synthesized with optimized parameters including feed ratio, reaction time, temperature, and pH, followed by purification process to obtain stable, boric-acid-based boron-rich (BAQDs). large-scale production BAQDs was implemented this dependable simple synthesis method. With content 15.47 wt %, the surpassed clinical drug...
The present article analyzes the dissipation characteristics of direct contact condensation (DCC) phenomenon that occurs when steam is injected into a water tank at subsonic speed using new modeling approach for entropy generation over calculation domain. developed assessment model based on local equilibrium hypothesis non-equilibrium thermodynamics. fluid flow and heat transfer processes are investigated numerically. To describe evaporation process vapor-liquid interface, phase change...
Boron neutron capture therapy (BNCT) induces intracellular nuclear reaction to destroy cancer cells during thermal irradiation. To selectively eliminate but avoid harmful effects on normal tissues, novel boron-peptide conjugates with angiopep-2, namely ANG-B, were constructed and evaluated in preclinical settings. Boron-peptide synthesized using solid-phase peptide synthesis, the molecular mass was validated by spectrometry afterwards. concentrations 6 cell lines an intracranial glioma mouse...
There is an incontestable need for improved treatment modality glioblastoma due to its extraordinary resistance traditional chemoradiation therapy. Boron neutron capture therapy (BNCT) may play a role in the future. We designed and synthesized 10B-boronated derivative of temozolomide, TMZB. BNCT was carried out with total radiation fluence 2.4 ± 0.3 × 1011 n/cm2. The effects TMZB were measured clonogenic cell survival assay vitro PET/CT imaging vivo. Then, phenylalanine (BPA) tested parallel...
Poor understanding and low clustering efficiency of massive data is a problem under the context big data. To solve this problem, MapReduce programming model adopted to combine Canopy K-means algorithms within cloud computing environment, so as fully make use storing capacity Hadoop clustering. Large quantities buyers on taobao are taken application do case study through platform’s mining set Mahout. General procedure for miming with Mahout also given.
Hydrogen bubble phenomenon is one of the key issues to be solved in development a long-life target system for boron neutron capture therapy (BNCT). In this study, we assessed kinetic behaviors H impurities nano-composite from atomic level. Firstly, two kinds Li/Ta nanolayer models were constructed, based on calculated lattice parameters and surface energies. The solution energy, diffusion mechanism, hydrogen bubbles formation nanostructured bilayer studied, through theoretical modeling...
In order to provide a theoretical basis for the thermal design of neutron production target, flow and heat transfer characteristics are studied by using numerical simulations experiments. A rectangular mini-channel experimental model consistent with geometric shape dissipation structure target was established, in which aspect ratio gap thickness test channel were 53.8:1 1.3 mm, respectively. The results indicate that critical Re is between 3500 4000, when reaches 21,000, Nu can reach 160....
Due to the existence of a Dean vortex in U-tube, flow and heat transfer process supercritical methane is complex, its thermophysical property are greatly influenced by different factors. Based on computational fluid dynamics theory, numerical simulation turbulent characteristics U-tube with an inner diameter 10 mm radius curvature 27 carried out using finite volume method. On basis verifying reliability model, influences inlet mass flux (G), tube wall boundary (q), pressure outlet (P),...
Spallation Neutron Source (CSNS) is a neutron facility with 100 kW beam power, which can be upgraded to 500 after several years irradiation.The moderator-reflector plug divided as Inner Reflector Plug (IRP) and Out (ORP) for cost saving.The IRP consists two moderators, beryllium (Be) reflectors upper shielding blocks.It should periodically replaced due radiation damage caused by intensity neutrons other secondary particles.Since the highly activated year irradiation, residual gamma rays...
Boron neutron capture therapy (BNCT) is expected to be an effective method of improving the treatment results on malignant brain glioma and melanoma, for which no successful has been developed so far. The beam shaping assembly (BSA) accelerator-based boron (A-BNCT) consists a moderator, reflector, gamma thermal shielding collimator. BSA moderates fast produced in target epithermal energy range. Design one key jobs BNCT project. An optimized study was conducted design facility based 3.5 MeV...
The Chinese Spallation Neutron Source (CSNS) is the national major scientific equipment, which will be completed around 2018. moderator core of CSNS parts, and uses three types to meet requirements different neutron wavelength pulse shapes, structure flow field Decoupled Poisoned Hydrogen Moderator (DPHM) most complicated. Currently, Computational Fluid Dynamics (CFD) primary tool for thermal design DPHM ensure reliability calculation result precision engineering requirements. In current...
This paper presents a coupling of the Monte Carlo method with computational fluid dynamics (CFD) to analyze flow channel design an irradiated target through numerical simulations. A novel series configuration is proposed, which effectively facilitates removal heat generated by high-power irradiation from without necessitating increase in cooling water rate. The research assesses performance both parallel and serial channels within target, revealing that, when subjected equivalent rates,...