A5052815465- Virology and Viral Diseases
- Data-Driven Disease Surveillance
- SARS-CoV-2 and COVID-19 Research
- Evolution and Genetic Dynamics
- COVID-19 epidemiological studies
- Bacteriophages and microbial interactions
- Mathematical and Theoretical Epidemiology and Ecology Models
- Viral Infectious Diseases and Gene Expression in Insects
- Bacterial Genetics and Biotechnology
- Influenza Virus Research Studies
- Viral Infections and Outbreaks Research
- Monoclonal and Polyclonal Antibodies Research
- Animal Disease Management and Epidemiology
- vaccines and immunoinformatics approaches
- CRISPR and Genetic Engineering
Pennsylvania State University
2023-2024
University of Idaho
2020-2022
The presence of heterogeneity in susceptibility, differences between hosts their likelihood becoming infected, can fundamentally alter disease dynamics and public health responses, for example, by changing the final epidemic size, duration an epidemic, even vaccination threshold required to achieve herd immunity. Yet, susceptibility is notoriously difficult detect measure, especially early epidemic. Here we develop a method that be used estimate given contact using tracing data, which are...
Abstract The presence of heterogeneity in susceptibility, differences between hosts their likelihood becoming infected, can fundamentally alter disease dynamics and public health responses, for example, by changing the final epidemic size, duration an epidemic, even vaccination threshold required to achieve herd immunity. Yet, susceptibility is notoriously difficult detect measure, especially early epidemic. Here we develop a method that be used estimate given contact using tracing data,...
Abstract The danger posed by emerging infectious diseases necessitates the development of new tools that can mitigate risk animal pathogens spilling over into human population. One promising approach is recombinant viral vaccines are transmissible, and thus capable self-dissemination through hard to reach populations wild animals. Indeed, mathematical models demonstrate transmissible greatly reduce effort required control spread zoonotic in their reservoirs, thereby limiting chances...
Genetically engineered organisms are prone to evolve in response the engineering. This evolution is often undesirable and can negatively affect purpose of Methods that maintain stability genomes therefore critical successful design use genetically organisms. One potential method limit unwanted by taking advantage ability gene flow counter local adaption, a process supplementation. Here, we investigate feasibility supplementation as mechanism offset evolutionary degradation transgene three...
While it is well established that host heterogeneity in transmission and susceptibility each individually impact disease dynamics characteristic ways, generally unknown how are impacted when both types of simultaneously present. Here we explore this question. We first conducted a systematic review published studies from which determined the effects correlations have been drastically understudied. then filled knowledge gaps by developing analyzing stochastic, individual-based SIR model...
We develop the mathematical structure of neutral coalescent with both replication-dependent and replication-independent mutations. This allows us to explain quantify empirical results that explore differences in genetic diversity bacterial cultures different growth rates. also derive an unbiased consistent estimator for mutation rate is based on a comparison total single nucleotide polymorphism counts two independent well-mixed In addition explaining between (but constant) rates, our...