A5087671533- Biosensors and Analytical Detection
- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced biosensing and bioanalysis techniques
- SARS-CoV-2 detection and testing
- Neuroscience and Neural Engineering
- Conducting polymers and applications
- Microfluidic and Capillary Electrophoresis Applications
- Ion channel regulation and function
- Renal Transplantation Outcomes and Treatments
- Non-Invasive Vital Sign Monitoring
- Cardiac electrophysiology and arrhythmias
- Analytical Chemistry and Sensors
- Hemodynamic Monitoring and Therapy
- Muscle activation and electromyography studies
- Intravenous Infusion Technology and Safety
- Electrical and Bioimpedance Tomography
- Cardiac Arrest and Resuscitation
- Heart Rate Variability and Autonomic Control
Colorado State University
2021-2022
Imperial College London
2016-2021
Imperial Valley College
2019
Transnational Press London
2019
Rapid and inexpensive serological tests for SARS-CoV-2 antibodies are needed to conduct population-level seroprevalence surveillance studies can improve diagnostic reliability when used in combination with viral tests. Here, we report a novel low-cost electrochemical capillary-flow device quantify IgG targeting nucleocapsid proteins (anti-N antibody) down 5 ng/mL low-volume (10 μL) human whole blood samples under 20 min. No sample preparation is as the integrates blood-filtration membrane...
Point-of-care (POC) methods currently available for detecting SARS-CoV-2 infections still lack accuracy. Here, we report the development of a highly sensitive electrochemical immunoassay capable quantitatively presence virus in patient nasopharyngeal samples using stencil-printed carbon electrodes (SPCEs) functionalized with capture antibodies targeting nucleocapsid protein (N protein). Samples are added to electrode surface, followed by horseradish peroxidase (HRP)-conjugated detection also...
Spreading depolarizations occur spontaneously and frequently in injured human brain. They propagate slowly through tissue often cycling around a local area of damage. Tissue recovery after an spreading depolarization requires greatly augmented energy utilisation to normalise ionic gradients from virtually complete loss membrane potential. In the brain, this is difficult because blood flow low unreactive. study, we use new variant microdialysis, continuous on-line observe effects on brain...
Developing tools that are able to monitor transient neurochemical dynamics is important decipher brain chemistry and function. Multifunctional polymer-based fibers have been recently applied modulate neural activity. Here, we explore the potential of polymer comprising six graphite-doped electrodes two microfluidic channels within a flexible polycarbonate body as platform for sensing pH neurometabolic lactate. Electrodes were made into potentiometric sensors (responsive pH) or amperometric...
Microfluidic devices optimised for real-time monitoring of the human brain.
The COVID-19 pandemic focused attention on a pressing need for fast, accurate, and low-cost diagnostic tests. This work presents an electrochemical capillary driven immunoassay (eCaDI) developed to detect SARS-CoV-2 nucleocapsid (N) protein. flow device is made of polyethylene terephthalate (PET) adhesive films. Upon addition sample, reagents washes are sequentially delivered integrated screen-printed carbon electrode detection, thus automating full sandwich with single end-user step....
Currently, there is a severe shortage of donor kidneys that are fit for transplantation, due in part to lack adequate viability assessment tools transplant organs. This work presents the integration novel wireless two-channel amperometric potentiostat with microneedle-based glucose and lactate biosensors housed 3D printed chip create microfluidic biosensing system genuinely portable. The transmits data via Bluetooth an Android app running on tablet. whole miniaturized fully enclosed can be...
Modular platform providing the building blocks to translate specialised microfluidics from laboratory a clinical environment.
This work describes a fully-integrated portable microfluidic analysis system for real-time monitoring of dynamic changes in glucose and lactate occurring the brain as result cardiac arrest resuscitation.
Emerging therapies in bioelectronic medicine highlight the need for deeper understanding of electrode material performance context tissue stimulation.Electrochemical properties are characterized on benchtop, facilitating standardization across experiments.On-nerve electrochemistry differs from benchtop characterization and relationship between electrochemical nerve activation thresholds not commonly established.This is important differences electrical stimulation requirements performance.We...