A5077638291- Animal Behavior and Reproduction
- Neuroendocrine regulation and behavior
- Neuroscience and Neural Engineering
- Animal Vocal Communication and Behavior
- Vagus Nerve Stimulation Research
- EEG and Brain-Computer Interfaces
- Hypothalamic control of reproductive hormones
- Ion channel regulation and function
- Muscle activation and electromyography studies
- Amphibian and Reptile Biology
- Hearing, Cochlea, Tinnitus, Genetics
- Healthcare and Venom Research
- Pain Mechanisms and Treatments
- Neural dynamics and brain function
- Neuroscience and Music Perception
- Fish Ecology and Management Studies
- Infant Health and Development
- Reproductive Biology and Fertility
- Estrogen and related hormone effects
- Hearing Loss and Rehabilitation
- Ovarian function and disorders
- Neurobiology and Insect Physiology Research
- Nicotinic Acetylcholine Receptors Study
- Vestibular and auditory disorders
- Birth, Development, and Health
Emory University
2009-2015
Pfizer (United Kingdom)
2012-2015
Pfizer (United States)
2014
Center for Neurosciences
2009-2014
The University of Texas at Austin
2003-2009
Universidade dos Açores
2002-2003
Arizona State University
2002
Boston University
2001
Significance Bioelectronic modulation of the autonomic nervous system innervating spleen represents a new therapeutic avenue. Studies in rodents suffer from limitation that stimulation parameters and anatomy are not directly applicable to humans. This work demonstrates translation biological mechanisms large animal model with similar anatomical, histological, functional characteristics for derivation human-relevant parameters. Here, we show scientific process translating bioelectronic...
A novel Parylene C-based peripheral nerve interface that combines both electrodes and microfluidic channels in an adjustable cuff was designed, fabricated, characterized. This minimally invasive incorporates a drug delivery system for targeted of lysing agents neurotrophic factors to the surface locally disrupt epineurium allow fascicular selectivity. Multiple platinum (Pt) were embedded neural stimulation recording. The lyse-and-attract electrode (LACE) uses simple locking mechanism is...
Abstract Neuromodulation is a new therapeutic pathway to treat inflammatory conditions by modulating the electrical signalling pattern of autonomic connections spleen. However, targeting this sub-division nervous system presents specific challenges in translating nerve stimulation parameters. Firstly, nerves are typically embedded non-uniformly among visceral and connective tissues with complex interfacing requirements. Secondly, these contain axons populations varying phenotypes leading...
Subcortical auditory nuclei were traditionally viewed as non-plastic in adulthood so that acoustic information could be stably conveyed to higher areas. Studies a variety of species, including humans, now suggest prolonged training can drive long-lasting brainstem plasticity. The neurobiological mechanisms for such changes are not well understood natural behavioral contexts due relative dearth vivo animal models which study this. Here, we demonstrate mouse model life experience with...
Mice are of paramount importance in biomedical research and their vocalizations a subject interest for researchers across wide range health-related disciplines due to increasingly important value as phenotyping tool models neural, speech language disorders. However, the mechanisms underlying auditory processing mice not well understood. The mouse audiogram shows peak sensitivity at frequencies between 15-25 kHz, but weaker higher ultrasonic which they typically vocalize. To investigate mice,...
In the Azorean rock‐pool blenny, sexually active males may adopt alternative reproductive tactics. present paper relationship between presence of satellite and success nest‐holders was investigated by comparing nests with without an associated male. Males male suffered more conspecific intrusions but they did not display a higher frequency attacks towards conspecifics. Nest‐holder were aggressive other conspecifics than satellites tolerance inversely correlated time spent in breeding...
High dose sodium salicylate causes moderate, reversible hearing loss and tinnitus. Salicylate-induced is believed to arise from a reduction in the electromotile response of outer hair cells (OHCs) and/or KCNQ4 potassium currents OHCs, which decreases driving force for transduction current. Therefore, enhancing OHC could potentially prevent salicylate-induced temporary loss. In this study, we tested whether opening voltage-gated channels using ICA-105665, novel small molecule that opens...
Abstract Age‐related cognitive decline presents serious lifestyle challenges, and anatomical changes to the hippocampus are often implicated in clinical conditions later life. However, relatively little is known about how hippocampal physiology altered transition middle‐age, when early detection may offer best opportunity for successful treatment. High‐yield extracellular recording a powerful tool understanding brain function freely moving animals at single‐cell resolution with millisecond...
Recent research supports that over-activation of the carotid body plays a key role in metabolic diseases like type 2 diabetes. Supressing signalling through sinus nerve (CSN) modulation may offer therapeutic approach for treating such diseases. Here we anatomically and histologically characterised CSN farm pig as recommended path to translational medicine. We developed an acute vivo porcine model assess application kilohertz frequency alternating current (KHFAC) evoked chemo-afferent...
Sensory processing in the spinal cord during disease states can reveal mechanisms for novel treatments, yet very little is known about pain at this level most commonly used animal models of articular pain. Here we report a test prediction that two clinically effective compounds, naproxen (an NSAID) and oxycodone opiate), are efficacious reducing response dorsal horn neurons to noxious knee joint rotation monosodium iodoacetate (MIA) sensitized rat. The overall objective these experiments was...
Emerging therapies in bioelectronic medicine highlight the need for deeper understanding of electrode material performance context tissue stimulation.Electrochemical properties are characterized on benchtop, facilitating standardization across experiments.On-nerve electrochemistry differs from benchtop characterization and relationship between electrochemical nerve activation thresholds not commonly established.This is important differences electrical stimulation requirements performance.We...
Introduction Polycystic ovary syndrome (PCOS) seems to be associated with increased ovarian sympathetic nerve activity and in rodent models of PCOS reducing the drive ovary, through denervation or neuromodulation, improves ovulation rate. We hypothesised that nerves work gonadotropins promote development survival small antral follicles develop a polycystic phenotype. Methods Using clinically realistic ovine model we showed rich innervation normal reinnervation after transplantation....