A5003278910- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Advanced Memory and Neural Computing
- Non-Invasive Vital Sign Monitoring
- Muscle activation and electromyography studies
- Wireless Body Area Networks
- Vagus Nerve Stimulation Research
- Pain Management and Treatment
- Blind Source Separation Techniques
- ECG Monitoring and Analysis
- Analog and Mixed-Signal Circuit Design
- Wireless Communication Security Techniques
- Microwave Imaging and Scattering Analysis
- Dementia and Cognitive Impairment Research
- Conducting polymers and applications
- Neurological disorders and treatments
- Geriatric Care and Nursing Homes
- Sleep and Work-Related Fatigue
- Nicotinic Acetylcholine Receptors Study
- Gait Recognition and Analysis
- Indoor and Outdoor Localization Technologies
- Intergenerational Family Dynamics and Caregiving
- Transcranial Magnetic Stimulation Studies
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
Imperial College London
2016-2025
UK Dementia Research Institute
2020-2025
University of Surrey
2021-2022
University College London
2021
Abstract Background People living with dementia often experience changes in independence and daily living, affecting their well-being quality of life. Behavioural correlate cognitive decline, functional impairment, caregiver distress, care availability. Methods We use data from a 3-year prospective observational study 141 people at home, using the Bristol Activities Daily Living Scale, Neuropsychiatric Inventory assessments, alongside self-reported healthcare-related data. Results Here we...
Modern microtechnology is enabling the channel count of neural recording integrated circuits to scale exponentially. However, raw data bandwidth these systems increasing proportionately, presenting major challenges in terms power consumption and transmission (especially for wireless systems). This paper presents a system that exploits sparse nature signals address provides reconfigurable low-bandwidth event-driven output. Specifically, we present novel 64-channel low-noise (2.1 μV <sub...
Objective: In recent years, radar technology has been extensively utilized in contactless human behavior monitoring systems. The unique capabilities of ultra-wideband (UWB) radars compared to conventional technologies, due time-of-flight measurements, present new untapped opportunities for in-depth movement during overground locomotion. This study aims investigate the deployability UWB accurately capturing gait patterns healthy individuals with no known walking impairments. Methods: A novel...
Ultra-wideband (UWB) radar technology has emerged as a promising alternative for creating portable and cost-effective in-home monitoring devices. Although there exists good evidence supporting its effectiveness in sleep monitoring, previous studies predominantly focus on younger, healthy participants. This research evaluates the applicability of commercial impulse UWB older people with neurodegenerative disorders (NDDs). 47 (mean age: 71.2 6.5, 18 prodromal or mild Alzheimer's disease)...
Introduction and aims Digital biomarkers can provide a cost-effective, objective robust measure for neurological disease progression, changes in care needs the effect of interventions. Motor function, physiology behaviour informative measures conditions neurodegenerative decline. New digital technologies present an opportunity to remote, high-frequency monitoring patients from within their homes. The purpose living lab study is develop novel functional impairment those with (NDD) conditions....
Chronic in-vivo neurophysiology experiments require highly miniaturized, remotely powered multi-channel neural interfaces which are currently lacking in power or flexibility post implantation. In this article, to resolve problem we present the SenseBack system, a post-implantation reprogrammable wireless 32-channel bidirectional interfacing that can enable chronic peripheral electrophysiology freely behaving small animals. The large number of channels for interface, coupled with fully...
Functional electrical stimulation is a powerful tool for restoration of function after nerve injury. However selectivity remains an issue. This paper presents alternative technique to obtain fiber size-selective nerves using FDA-approved electrode implants. The was simulated the ventral roots Xenopus Laevis, motivated by application in bladder control. relies on applying high frequency alternating current filter out action potentials larger fibers, resulting selective smaller fibers. Results...
Objective. This paper describes the design, testing and use of a novel multichannel block-capable stimulator for acute neurophysiology experiments to study highly selective neural interfacing techniques. demonstrates stimulator's ability excite inhibit nerve activity in rat sciatic model concurrently using monophasic biphasic stimulation as well high-frequency alternating current (HFAC). Approach. The proposed uses Howland Current Pump circuit main analogue element. 4 output channels with...
This study details the development of a novel, approx. £20 electroencephalogram (EEG)-based brain-computer interface (BCI) intended to offer financially and operationally accessible device that can be deployed on mass scale facilitate education public engagement in domain EEG sensing neurotechnologies. Real-time decoding steady-state visual evoked potentials (SSVEPs) is achieved using variations widely-used canonical correlation analysis (CCA) algorithm: multi-set CCA generalised CCA. All...
This paper describes a fully implantable and highly compact neural interface platform for chronic (> 6 month) rat small rodent experiments. It provides 32 channels of flexible stimulation recording with wireless control data readout, as well transcutaneous power (although waste remains challenge). All the system firmware is upgradeable over air (even after implantation) allowing future enhancements such closed loop operation or filtering. focuses on implant considerations - i.e. design...
This paper presents a novel 32-channel bidirectional neural interface, capable of high voltage stimulation and low-power, low-noise recording. Current-controlled biphasic pulses are output with compliance 9.25 V, user-configurable amplitude (max. 315 μA) & phase duration 2 ms). The low-voltage recording amplifiers consume 23 μW per channel programmable gain between 225-4725. Signals 10-bit sampled at 16 kHz. Data rates reduced by granular control active channels, spike detection event-driven...
This paper describes Tiresias, a low-cost, unobtrusive networked radar system designed to monitor vulnerable patients in domestic environments and provide high quality behavioural health data. Dementia is disease that affects millions worldwide progressively degrades an individual's ability care for themselves. Eventually most people living with dementia will need reside assisted facilities as they become unable Understanding the effects has on self-care extending length of time can remain...
High-Frequency alternating current nerve block has great potential for neuromodulation-based therapies. However, no precise measurements have been made of the time needed nerves to recover from once signal turned off. This study aims characterise recovery rat sciatic after 30 seconds at varying amplitudes and frequencies. Experiments were carried out invivo quantify times completeness within 0.7 s end block. The was blocked with an square wave amplitude frequency ranging 2 9mA 10 50 kHz...
The unobtrusive monitoring of vital signals and behaviour can be used to gather intelligence support the care people living with dementia. This provide insights into persons wellbeing neurogenerative process, as well enable them continue live safely at home, thereby improving their quality life. Within this context, study investigated deployability non-contact respiration rate (RR) measurement based on an Ultra-Wideband (UWB) radar System-on-Chip (SoC). An algorithm was developed...
Abstract Objective High-Frequency alternating current (HFAC) nerve block has great potential for neuromodulation-based therapies. However function recovery dynamics after a is highly understudied. This study aims to characterise the of neural an HFAC block. Approach Experiments were carried out in-vivo determine blocking efficacy as signal amplitude and frequency, times well completeness was measured within 0.7 s time scale from end The sciatic stimulated at 100 Hz during reduce error ±10 ms...
Emerging therapies in bioelectronic medicine highlight the need for deeper understanding of electrode material performance context tissue stimulation.Electrochemical properties are characterized on benchtop, facilitating standardization across experiments.On-nerve electrochemistry differs from benchtop characterization and relationship between electrochemical nerve activation thresholds not commonly established.This is important differences electrical stimulation requirements performance.We...
Neural prostheses, such as cochlear implants or deep brain stimulators, can modulate neural activity and restore lost physiological function by performing electrical stimulation recordings. However, prolonged degrade electrodes adversely affect their performance over long-term implantation. Therefore, integrating the electrodes' health monitoring system is required for new implantable interface designs. validating electrode degradation with in-vivo experiment slow highly challenging....
The unobtrusive monitoring of vital signals and behaviour can be used to gather intelligence support the care people living with dementia. This provide insights into person's wellbeing neurogenerative process, as well enable them continue live safely at home, thereby improving their quality life. Within this context, study investigated deployability non-contact respiration rate (RR) measurement based on an Ultra-Wideband (UWB) radar System-on-Chip (SoC). An algorithm was developed...
Neurostimulations which use High Frequency Alternating Current (HFAC) block show great promise for neuromodulatory therapies. Treatments have been developed various health conditions including obesity and related risks, now even stomach cancer treatments are being considered. However the mechanism of is still not completely clear, as well how neural electrode parameters affect it. In order to study conduction during HF stimulation in mammalian axons, we describe a detailed computational...
This paper describes high-frequency nerve block experiments carried out on rat sciatic nerves to measure the speed of recovery A fibres from carryover. Block carryover is process by which excitability remains suppressed temporarily after High Frequency Alternative (HFAC) turned off following its application. In this series 5 were extracted and prepared for ex-vivo stimulation recording in a specially designed perfusion chamber. For each repeated HFAC concurrent trials observe signal shutoff....
Ex vivo preparations enable the study of many neurophysiological processes in isolation from rest body while preserving local tissue structure. This work describes preparation rat sciatic nerves for ex neurophysiology, including buffer preparation, animal procedures, equipment setup and recording. provides an overview different types experiments possible with this method. The outlined method aims to provide 6 h stimulation recording on extracted peripheral nerve tightly controlled conditions...
Objective: This paper describes the design, testing and use of a novel multichannel block-capable stimulator for acute neurophysiology experiments to study highly selective neural interfacing techniques. demonstrates stimulator's ability excite inhibit nerve activity in rat sciatic model concurrently using monophasic biphasic stimulation as well high-frequency alternating current (HFAC). Approach: The proposed uses Howland Current Pump circuit main analogue element. 4 output channels with...
Simulations of electroneurogram recording could help find the optimal set electrodes and algorithms for selective neural recording. However, no flexible methods are established as stimulation. This paper proposes a method to couple compartmental FEM nerve model, implemented in NEURON COMSOL, respectively, translate Node Ranvier currents into extraneural electric fields. The study simulate ex-vivo experimental conditions, allows flexibility electrode geometries topologies. model has been made...
Neural interfaces, and more specifically ones of the invasive/implantable variety, today are a topic much controversy, often making general public uncomfortable intimidated. We have thus devised bespoke interactive demo to help people understand brain implants their need in age wearable devices, with secondary objective introducing wireless cortical neural probe that we, at NGNI (Next Generation Interfaces) lab, developing.