A5022805187- Advanced X-ray Imaging Techniques
- Advanced Electron Microscopy Techniques and Applications
- Fossil Insects in Amber
- Photoacoustic and Ultrasonic Imaging
- Hymenoptera taxonomy and phylogeny
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Cultural Heritage Materials Analysis
- Advanced Neuroimaging Techniques and Applications
- Nanoplatforms for cancer theranostics
- Gut microbiota and health
- Plant and animal studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Dementia and Cognitive Impairment Research
- Cellular Mechanics and Interactions
- Retinal and Macular Surgery
- Heat shock proteins research
- Urinary Tract Infections Management
- Advanced Fluorescence Microscopy Techniques
- Machine Learning and Data Classification
- Amyotrophic Lateral Sclerosis Research
- Alzheimer's disease research and treatments
- Morphological variations and asymmetry
- Advanced Chemical Sensor Technologies
Istituto di Nanotecnologia
2019-2025
UK Dementia Research Institute
2023-2025
Imperial College London
2023-2024
Great Ormond Street Hospital
2024
University College London
2024
Istituto Nanoscienze
2020-2024
Sapienza University of Rome
2021-2024
University of Siena
2024
University of Palermo
2024
Roma Tre University
2023
In the field of medical diagnosis and patient monitoring, effective pattern recognition in neurological time-series data is essential. Traditional methods predominantly based on statistical or probabilistic learning inference often struggle with multivariate, multi-source, state-varying, noisy while also posing privacy risks due to excessive information collection modeling. Furthermore, these overlook critical information, such as distribution points inherent uncertainties. To address...
Abstract Urinary Tract Infections (UTIs) are one of the most prevalent bacterial infections in older adults and a significant contributor to unplanned hospital admissions People Living with Dementia (PLWD), early detection being crucial due predicament reporting symptoms limited help-seeking behaviour. The common diagnostic tool is urine sample analysis, which can be time-consuming only employed where UTI clinical suspicion exists. In this method development proof-of-concept study,...
Abstract Background People living with dementia often experience changes in independence and daily living, affecting their well-being quality of life. Behavioural correlate cognitive decline, functional impairment, caregiver distress, care availability. Methods We use data from a 3-year prospective observational study 141 people at home, using the Bristol Activities Daily Living Scale, Neuropsychiatric Inventory assessments, alongside self-reported healthcare-related data. Results Here we...
Alzheimer’s disease (AD), a debilitating neurodegenerative disorder, remains one of the foremost public health challenges affecting more than 30 million people worldwide with etiology still largely enigmatic. The intricate gut-brain axis, serving as vital communication network between gut and brain, appears to wield influence in progression AD. Our study showcases remarkable precision x-ray phase-contrast tomography (XPCT) conducting an advanced three-dimensional examination cellular...
Abstract Fossils sometimes show unusual morphological features absent in living organisms, making it difficult to reconstruct both their affinity and function. We describe here a new lacewing larva, Ankyloleon caudatus gen. et sp.n. (Neuroptera) from the Cretaceous amber of Myanmar, characterized by an abdomen unique among insects, with ‘tail‐like’ terminal segments bearing ventral pair vesicles. Phase‐contrast X‐ray microtomography reveals that these structures were dense equipped median...
Recent trends in hard X-ray micro-computed tomography (microCT) aim at increasing both spatial and temporal resolutions. These challenges require intense photon beams. Filtered synchrotron radiation beams, also referred to as `pink beams', which are emitted by wigglers or bending magnets, meet this need, owing their broad energy range. In work, the new microCT station installed biomedical beamline ID17 of European Synchrotron is described an overview preliminary results obtained for...
Only a few Herculaneum rolls exhibit writing on their reverse side. Since unrolled papyri are permanently glued to paperboard, so far, this fact was known us only from 18th-century drawings. The application of shortwave-infrared (SWIR; 1000-2500 nm) hyperspectral imaging (HSI) one them (PHerc. 1691/1021) has revealed portions Greek text hidden the back more than 220 years after first discovery, making it possible recover primary source for ongoing new edition precious book. SWIR HSI produced...
Abstract The 3D complexity of biological tissues and intricate structural-functional connections call for state-of-the-art X-ray imaging approaches to overcome limitations classical imaging. Unlike other techniques, phase-contrast tomography (XPCT) offers a highly sensitive approach investigate different disease-relevant networks at levels ranging from single cell through intact organ. We present here concomitant study the evolution tissue damage inflammation in organs affected by disease...
Alzheimer’s Disease (AD) is a progressively debilitating form of dementia that affects millions individuals worldwide. Although vast amount research has investigated the complex interplay between gut microbiota and neurodegeneration, metaproteomic effects on AD pathogenesis remain largely uncharted territory. This study aims to reveal role in pathogenesis, particularly regarding changes proteome molecular pathways are intricately linked disease progression. We operated state-of-the-art...
Many ocular diseases are associated with an alteration of the mechanical and material properties eye. These mechanically-related include macular hole pucker, two conditions due to presence abnormal physical tractions acting on retina. A complete relief these can be obtained through a challenging microsurgical procedure, which requires peeling internal limiting membrane retina (ILM). In this paper, we provide first comparative study nanoscale morphological ILM in pucker. Our elastic...
We report a qualitative study on central nervous system (CNS) damage that demonstrates the ability of X-ray phase contrast tomography (XPCT) to confirm data obtained with standard 2D methodology and permits description additional features are not detected or other 3D techniques. In magnetic resonance computed tomography, XPCT makes possible high-resolution imaging soft tissues classically considered “invisible” X-rays without use agents, need for intense processing tissue required by Most...
Abstract Ancient Herculaneum papyrus scrolls, hopelessly charred in the 79 A.D. Vesuvius eruption, contain valuable writings of Greek philosophers day, including works Epicurean Philodemus. X-ray phase contrast tomography has recently begun unlocking their secrets. However, only small portions text hidden inside scroll have been recover. One challenging tasks papyri investigation is virtual unfolding because highly complicated structure and three-dimensional arrangement. Although this...
Abstract This work addresses the authenticity issue of fake potteries circulating in illicit art market, imitating ancient artefacts, by an interdisciplinary and a multi‐analytical approach. In faking manufacture, unscrupulous forgers use increasingly advanced skills to mimic materials technologies produce artificial ageing. Despite phenomenon archaeological objects' forgery is considered crime source earnings, there are not enough works literature support difficult unmasking objects. this...
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting motor neurons. Pre-clinical studies drive the development of animal models that well mimic ALS and enable both dissection disease processes an early assessment therapy efficacy. A comprehensive knowledge neuronal vascular lesions in brain spinal cord essential factor to understand disease. Spatial resolution bidimensional imaging are important drawbacks limiting current neuroimaging tools, while...
Pineal gland (PG) is a part of the human brain epithalamus that plays an important role in sleep, circadian rhythm, immunity, and reproduction. The calcium deposits lesions PG interfere with normal function organ can be associated different health disorders including serious neurological diseases. At moment, detailed mechanisms calcifications formation as well their involvement pathological processes are not fully understood. deep comprehensive study structure uncut histological details,...
Glioblastoma multiforme (GBM) is one of the deadliest and most aggressive cancers, remarkably resilient to current therapeutic treatments. Here, we report preliminary in vivo studies GBM treatments based on photo-nanotherapeutics activate synergistic killing mechanisms. Core-shell nanoparticles have been weaponized by combining photophysical properties a new generation PDT agent (Ir(III) complex) with thermoplasmonic effects resonant gold nanospheres. In order investigate damages induced...
The formation of concrements in human pineal gland (PG) is a physiological process and, according to many researchers, associated with the involution PG structures. majority scientific publications concern progressive calcification PG, leaving out studies on destruction already formed calcified concrements. Our study fills gap knowledge about zones normal aging and neuropathological conditions, which has not been addressed until now.Our objective gain insight into tissue impairment both...
Abstract Dance flies and relatives (Empidoidea) are a diverse ecologically important group of Diptera in nearly all modern terrestrial ecosystems. Their fossil record, despite being scattered, attests to long evolutionary history dating back the early Mesozoic. Here, we describe seven new species Empidoidea from Cretaceous Kachin amber inclusions, assigning them genus Electrochoreutes gen.n. (type species: trisetigerus sp.n. ) based on unique apomorphies among known Diptera. Like many extant...
Introduction: In the study of neurodegenerative diseases, possibility to follow fate specific cells or molecules within whole body would be a milestone better understand complex evolution disease mechanisms and monitor effects therapies. The techniques available today do not allow visualization disease-relevant tridimensional biological context at high spatial resolution. Methods: Here we show results from first validation steps novel approach: by combining conjugate nanobodies anti-glial...
The proximal caudal vertebrae and notochord in thick-toed geckos (TG) (Chondrodactylus turneri, Gray, 1864) were investigated after a 30-day space flight onboard the biosatellite Bion-M1. This region has not been explored previous studies. Our research focused on finding sites most affected by demineralization caused microgravity (G0). We used X-ray phase-contrast tomography to study TG samples without invasive prior preparation clarify our findings resistance of TG's bones G0. results...
Alzheimer's disease (AD), a debilitating neurodegenerative disorder, remains one of the foremost public health challenges our time. Despite decades research, its etiology largely enigmatic. Recently, attention has turned to gut-brain axis, complex network communication between gastrointestinal tract and brain, as potential player in pathogenesis AD. Here we exploited X-ray Phase Contrast Tomography provide an in-depth analysis link gut condition AD, exploring anatomy structure murine models....
<title>Abstract</title> The larvae of Neuroptera are predators that feed by injecting bioactive compounds into their prey and then suctioning the fluids through modified mouthparts. We explore evolutionary history this feeding structure examination a new fossil larva preserved in Late Cretaceous Kachin amber, which we describe as genus species, <italic>Electroxipheus veneficus</italic> gen et sp. nov. X-ray phase-contrast microtomography enabled us to study anatomy 3D, including...