A5018068321- Sleep and related disorders
- Sleep and Wakefulness Research
- Obstructive Sleep Apnea Research
- Circadian rhythm and melatonin
- EEG and Brain-Computer Interfaces
- Sleep and Work-Related Fatigue
- Non-Invasive Vital Sign Monitoring
- Dementia and Cognitive Impairment Research
- Context-Aware Activity Recognition Systems
- Heart Rate Variability and Autonomic Control
- Health, Environment, Cognitive Aging
- Cardiovascular and exercise physiology
- Ocular Surface and Contact Lens
- Restless Legs Syndrome Research
- Geriatric Care and Nursing Homes
- Aging and Gerontology Research
- Neural dynamics and brain function
- Bullying, Victimization, and Aggression
- Paranormal Experiences and Beliefs
- Epilepsy research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Olfactory and Sensory Function Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Child Development and Digital Technology
- Biofield Effects and Biophysics
UK Dementia Research Institute
2021-2025
University of Surrey
2015-2025
Imperial College London
2021-2025
Surrey and Borders Partnership NHS Foundation Trust
2024
Sleep Research Society
2023
University of Campania "Luigi Vanvitelli"
2011-2016
University of Naples Federico II
2015
Sleep and its sub-states are assumed to be important for brain function across the lifespan but which aspects of sleep associate with various cognition, mood self-reported quality has not yet been established in detail. was quantified by polysomnography, quantitative Electro-Encephalo-Gram (EEG) analysis self-report 206 healthy men women, aged 20-84 years, without complaints. Waking five assessments scheduled day covering objectively assessed performance cognitive domains including sustained...
Quantification of sleep is important for the diagnosis disorders and research. However, only widely accepted method to obtain staging by visual analysis polysomnography (PSG), which expensive time consuming. Here, we investigate automated scoring based on a low-cost, mobile electroencephalogram (EEG) platform consisting lightweight EEG amplifier combined with flex-printed cEEGrid electrodes placed around ear, can be implemented as fully self-applicable system. signals have different...
Electroencephalography (EEG) recordings represent a vital component of the assessment sleep physiology, but methodology presently used is costly, intrusive to participants, and laborious in application. There recognized need develop more easily applicable yet reliable EEG systems that allow unobtrusive long-term recording sleep-wake ideally away from laboratory setting. cEEGrid recently developed flex-printed around-the-ear electrode array, which holds great potential for monitoring...
To compare the 24-hour sleep assessment capabilities of two contactless technologies (CSTs) to actigraphy in community-dwelling older adults.We collected 7-14 days data at home from 35 adults (age: 65-83), some with medical conditions, using Withings Sleep Analyser (WSA, n = 29), Emfit QS (Emfit, 17), a standard device (Actiwatch Spectrum [AWS, 34]), and diary (n 35). We compared nocturnal daytime measures estimated by CSTs without information (AWS-A) against sleep-diary-assisted...
Abstract Background People living with dementia often experience changes in independence and daily living, affecting their well-being quality of life. Behavioural correlate cognitive decline, functional impairment, caregiver distress, care availability. Methods We use data from a 3-year prospective observational study 141 people at home, using the Bristol Activities Daily Living Scale, Neuropsychiatric Inventory assessments, alongside self-reported healthcare-related data. Results Here we...
Abstract Study Objectives Portable electroencephalography (EEG) devices offer the potential for accurate quantification of sleep at home but have not been evaluated in relevant populations. We assessed Dreem headband (DHB) and its automated staging algorithm 62 older adults [age (mean±SD) 70.5±6.7 years; 12 Alzheimer’s]. Methods The accuracy measures, epoch-by-epoch staging, quality EEG signals quantitative (qEEG) analysis were compared to standard polysomnography (PSG) a laboratory. Results...
Contactless sleep technologies (CSTs) hold promise for longitudinal, unobtrusive monitoring in the community and at scale. They may be particularly useful older populations wherein disturbance, which indicative of deterioration physical mental health, is highly prevalent. However, few CSTs have been evaluated people.
Sleep and circadian rhythm disturbance are predictors of poor physical mental health, including dementia. Long-term digital technology-enabled monitoring sleep rhythms in the community has great potential for early diagnosis, disease progression, assessing effectiveness interventions. Before novel technology-based can be implemented at scale, its performance acceptability need to evaluated compared gold-standard methodology relevant populations. Here, we describe our protocol evaluation...
Abstract Plasma biomarkers of dementia, including phosphorylated tau (p-tau217), offer promise as tools for diagnosis, stratification clinical trials, monitoring disease progression, and assessing the success interventions in those living with Alzheimer’s disease. However, currently, it is unknown whether these dementia biomarker levels vary time day, which could have implications their value. In two protocols, we studied 38 participants (70.8 ± 7.6 years; mean SD) a 27-h laboratory protocol...
Ultra-wideband (UWB) radar technology has emerged as a promising alternative for creating portable and cost-effective in-home monitoring devices. Although there exists good evidence supporting its effectiveness in sleep monitoring, previous studies predominantly focus on younger, healthy participants. This research evaluates the applicability of commercial impulse UWB older people with neurodegenerative disorders (NDDs). 47 (mean age: 71.2 6.5, 18 prodromal or mild Alzheimer's disease)...
Introduction: Portable electroencephalography (EEG) devices offer the potential for accurate quantification of sleep at home but have not been evaluated in relevant populations. Methods: We assessed Dreem headband (DHB), and its automated staging algorithm 62 older adults [Age (mean±SD) 70.5±6.7 years; 12 Alzheimers]. The accuracy measures, epoch-by-epoch staging, quality EEG signals quantitative (qEEG) analysis was compared to standard polysomnography (PSG) a laboratory. Results: DHB...
Summary Recently, evidence has emerged that the phases of moon may modulate subjective sleep quality and polysomnographically assessed structure in humans. We aimed to explore further putative effects circa‐lunar periodicity (~29.5 days) on objective parameters human a retrospective analysis. The baseline recordings 205 (91 males 114 females; mean age = 47.47 years, standard deviation =19.01; range: 20–84 years) healthy carefully screened participants who participated two clinical trials...
Sleep monitoring has extensively utilized electroencephalogram (EEG) data collected from the scalp, yielding very large repositories and well-trained analysis models. Yet, this wealth of is lacking for emerging, less intrusive modalities, such as ear-EEG. The current study seeks to harness abundance open-source scalp EEG datasets by applying models pre-trained on data, either directly or with minimal fine-tuning; achieved in context effective sleep ear-EEG that was recorded using a single...
Longitudinal monitoring of vital signs provides a method for identifying changes to general health in an individual, particularly older adults. The nocturnal sleep period convenient opportunity assess signs. Contactless technologies that can be embedded into the bedroom environment are unintrusive and burdenless have potential enable seamless To realize this potential, these need evaluated against gold standard measures relevant populations.
Aim of this study was to confirm the increase friendship competence and its multifactorial nature in kindergarten primary school children verify gender differences, parenting socioeconomic status influences on concept. A semi-structured interview administered a natural context 3–8 years-old (N = 99; mean 6.1 years; SD 1.35). The coding provides five sub-categories: (1) friendship; (2) social perspective taking; (3) emotions understanding; (4) interaction strategies; (5) aggressiveness. Three...
Despite its clinical importance, the issue of diurnal time course sleepiness and performance in children remains largely unexplored. The objective this study is to draw a profile daytime subjective performance, at simple complex tasks, cohort Italian primary school children.To aim, sample 316 (age range: 5-11 years; mean 8.2 ± 1.5) was recruited sub-divided into three groups, according age: Group 1 (5-7 N = 127), 2 (8-9 108), 3 (10-11 81). Subjective were evaluated, respectively, through...
Nocturnal disturbance is frequently observed in dementia and a major contributor to institutionalisation. Unobtrusive technology that can quantify sleep/wake determine bed occupancy during the nocturnal sleep episode may be beneficial for long-term clinical monitoring carer. Such technologies have, however, not been validated older people. Here we assessed performance of Withings Sleep Mattress (WSM) heterogenous population ensure external validity.Eighteen participants (65 - 80 years,...
Wearable heart rate monitors offer a cost-effective way of non-invasive, long-term monitoring cardiac health. Validation wearable technologies in an older populations is essential for evaluating their effectiveness during deployment healthcare settings. To this end, we evaluated the validity measures from device, Empatica E4, and compared them to electrocardiography (ECG). We collected E4 data simultaneously with ECG thirty-five men women overnight sleep recording laboratory. propose robust...
People living with dementia (PLWD) often exhibit marked sleep disturbances. These cause substantial care challenges and may be causally related to progression. Collecting ecologically valid data on disturbance in naturalistic settings has been difficult. As a result, assessments PLWD are generally limited short studies laboratories or collection from wearables, where compliance is problematic. Here, we demonstrate how passive internet of things (IoT) sensors can used monitor the effects...
The effects of orexinergic peptides are diverse and mediated by orexin-1 orexin-2 receptors. Antagonists that target both receptors have been shown to promote sleep initiation maintenance. Here, we investigated the role receptor in regulation a randomised, double-blind, placebo-controlled, three-period crossover clinical trial using two doses (20 50 mg) highly selective antagonist (2-SORA) (JNJ-48816274). We used phase advance model disruption where is scheduled circadian wake maintenance...
The roles of personality traits, as assessed by Eysenck Personality Inventory, and the clock gene PERIOD3 (PER3) were analysed on subjective effects prolonged wakefulness. A sample 70 healthy participants (7 men, 63 women; M age = 24.2 yr., SD 3.2) was studied during forced wakefulness between 7:30 p.m. 9:30 a.m. According to Eysenck's arousal model, it hypothesized that might affect in a different way those classified Introverted Extraverted. During period, group showed greater decrease...
Introduction Disturbances of sleep/wake behaviour are amongst the most disabling symptoms dementia, leading to increased carers’ burden and institutionalisation. The lack unobtrusive, low- technologies validated monitor sleep in patients living with dementia (PLWD) has prevented longitudinal studies nocturnal disturbances their correlates. Aims To examine effect medication changes clinical status on intraindividual variation PLWD. Methods Using under-mattress pressure-sensing mat 46 PLWD, we...
<sec> <title>BACKGROUND</title> Contactless sleep technologies (CSTs) hold promise for longitudinal, unobtrusive monitoring in the community and at scale. They may be particularly useful older populations wherein disturbance, which indicative of deterioration physical mental health, is highly prevalent. However, few CSTs have been evaluated people. </sec> <title>OBJECTIVE</title> This study performance 3 compared to polysomnography (PSG) actigraphy an population. <title>METHODS</title>...