A5057547399- Neuroscience and Neuropharmacology Research
- Vagus Nerve Stimulation Research
- Neuroscience and Neural Engineering
- Pain Mechanisms and Treatments
- Epilepsy research and treatment
- Nicotinic Acetylcholine Receptors Study
- Sleep and Wakefulness Research
- Cannabis and Cannabinoid Research
- Ion channel regulation and function
- Healthcare and Venom Research
- Heart Rate Variability and Autonomic Control
- Neurotransmitter Receptor Influence on Behavior
- Botulinum Toxin and Related Neurological Disorders
- Lipid Membrane Structure and Behavior
- Neuroendocrine regulation and behavior
- Regulation of Appetite and Obesity
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Adipose Tissue and Metabolism
- Memory and Neural Mechanisms
- Neuroscience of respiration and sleep
- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
GlaxoSmithKline (United Kingdom)
2008-2012
GlaxoSmithKline (Italy)
2004-2010
University of Nottingham
2000-2003
Queen's Medical Centre
2000
Significance Bioelectronic modulation of the autonomic nervous system innervating spleen represents a new therapeutic avenue. Studies in rodents suffer from limitation that stimulation parameters and anatomy are not directly applicable to humans. This work demonstrates translation biological mechanisms large animal model with similar anatomical, histological, functional characteristics for derivation human-relevant parameters. Here, we show scientific process translating bioelectronic...
Summary Retigabine [RTG (international nonproprietary name); ezogabine (EZG; U.S. adopted name)] is a first‐in‐class antiepileptic drug (AED) that reduces neuronal excitability by enhancing the activity of KCNQ (K v 7) potassium + ) channels. RTG/EZG has recently been approved European Medicines Agency and Food Drug Administration as adjunctive therapy in adults with partial‐onset seizures. In this review we discuss demonstrated across broad spectrum vitro/in vivo animal models seizures,...
Neuromodulation of the immune system has been proposed as a novel therapeutic strategy for treatment inflammatory conditions. We recently demonstrated that stimulation near-organ autonomic nerves to spleen can be harnessed modulate response in an anesthetized pig model. The development neuromodulation therapy clinic requires chronic efficacy and safety testing large animal This manuscript describes effects longitudinal conscious splenic nerve chronically-implanted pigs. Firstly,...
Abstract Neuromodulation is a new therapeutic pathway to treat inflammatory conditions by modulating the electrical signalling pattern of autonomic connections spleen. However, targeting this sub-division nervous system presents specific challenges in translating nerve stimulation parameters. Firstly, nerves are typically embedded non-uniformly among visceral and connective tissues with complex interfacing requirements. Secondly, these contain axons populations varying phenotypes leading...
What is the central question of this study? are effects insulin and insulin-induced hypoglycaemia on carotid body chemoreceptor activity in vivo how do stimulation-mediated cardiorespiratory responses beagle dogs compare during euglycaemia hypoglycaemia? main finding its importance? Intracarotid administration leads to sustained increase respiratory response with significant cardiovascular effects. Insulin-induced exacerbated NaCN-mediated enhanced reflex response. These findings suggest...
Recent research supports that over-activation of the carotid body plays a key role in metabolic diseases like type 2 diabetes. Supressing signalling through sinus nerve (CSN) modulation may offer therapeutic approach for treating such diseases. Here we anatomically and histologically characterised CSN farm pig as recommended path to translational medicine. We developed an acute vivo porcine model assess application kilohertz frequency alternating current (KHFAC) evoked chemo-afferent...
GABAB receptors modulate primary afferent fibre evoked responses of spinal neurones. Here effects the selective receptor antagonist, CGP-35348, on electrically-evoked neurones in control and carrageenan-inflamed rats were studied. Spinal CGP-35348 (0.1–10 μg/50 μl) did not alter Aβ- or Aδ-fibre neuronal rats, although C-fibre post discharge significantly facilitated by 3.0 10.0 μl (p < 0.05). In carrageenan-treated animals, electrically at any dose. Our data suggest that following acute...