A5001821173- Nicotinic Acetylcholine Receptors Study
- Vagus Nerve Stimulation Research
- Veterinary Equine Medical Research
- Veterinary Oncology Research
- Gastrointestinal motility and disorders
- Olfactory and Sensory Function Studies
- Neuroscience and Neural Engineering
- Prenatal Screening and Diagnostics
- Autoimmune Bullous Skin Diseases
- Cardiovascular Conditions and Treatments
- Heart Rate Variability and Autonomic Control
- Gastrointestinal disorders and treatments
- Osteoarthritis Treatment and Mechanisms
- Total Knee Arthroplasty Outcomes
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Myopathies and Dermatomyositis
- Neonatal Respiratory Health Research
- Immunodeficiency and Autoimmune Disorders
- Skin Diseases and Diabetes
- Congenital Diaphragmatic Hernia Studies
- IL-33, ST2, and ILC Pathways
Royal Veterinary College
2017-2023
Significance Bioelectronic modulation of the autonomic nervous system innervating spleen represents a new therapeutic avenue. Studies in rodents suffer from limitation that stimulation parameters and anatomy are not directly applicable to humans. This work demonstrates translation biological mechanisms large animal model with similar anatomical, histological, functional characteristics for derivation human-relevant parameters. Here, we show scientific process translating bioelectronic...
The magnitude of innate inflammatory immune responses is dependent on interactions between peripheral neural and cells. In particular, a cholinergic anti-inflammatory pathway (CAP) has been identified in the spleen whereby noradrenaline (NA) released by splenic nerves binds to ß2-adrenergic receptors (β2-AR) CD4+ T cells which, turn, release acetylcholine (ACh). binding ACh α7 (α7-AChR) expressed macrophages inhibits production cytokines, including tumor necrosis factor (TNF). However, role...
Neuromodulation of the immune system has been proposed as a novel therapeutic strategy for treatment inflammatory conditions. We recently demonstrated that stimulation near-organ autonomic nerves to spleen can be harnessed modulate response in an anesthetized pig model. The development neuromodulation therapy clinic requires chronic efficacy and safety testing large animal This manuscript describes effects longitudinal conscious splenic nerve chronically-implanted pigs. Firstly,...
Background Perinuclear antineutrophil cytoplasmic antibodies ( pANCA ) previously have been shown to be serum markers in dogs with chronic enteropathies, that food‐responsive disease FRD having higher frequencies of seropositivity than steroid‐responsive SRD ). The indirect immunofluorescence IIF assay used previous publications is time‐consuming perform, low interobserver agreement. Hypothesis/Objectives We hypothesized a commercially available granulocyte designed for humans could detect...
The exact pathogenesis of idiopathic inflammatory bowel disease (IBD) in humans as well dogs remains largely unknown, although it is believed to represent a multifactorial immune-mediated disease, resulting from complex interplay between the mucosal immune system and intestinal microbiome genetically susceptible individuals.1 Many studies have attempted identify mediators mucosa affected dogs, with no predominant cytokine pattern emerging.2, 3 In human IBD, mouse models activation...
Autologous conditioned serum (ACS), i.e enriched with anti-inflammatory cytokines and growth factors, is a popular orthobiologic therapy used in equine practice. Costly specialized tubes containing glass beads are commonly for ACS production. The objective of this vitro study was to compare cytokine factor levels after incubation three different tubes: commercial plastic (COMM); sterile 50 ml centrifugation (CEN); 10 vacutainer (VAC). Blood from 15 healthy horses incubated the at 37°C 22-24...