A5069792380- Dialysis and Renal Disease Management
- Central Venous Catheters and Hemodialysis
- Muscle and Compartmental Disorders
- Acute Kidney Injury Research
- Renal function and acid-base balance
- Pharmacological Effects and Toxicity Studies
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Blood Pressure and Hypertension Studies
- Restless Legs Syndrome Research
- Vascular Procedures and Complications
- Disaster Response and Management
- Acute Ischemic Stroke Management
- Cardiac Imaging and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Bacterial Identification and Susceptibility Testing
- Organ Donation and Transplantation
- Parathyroid Disorders and Treatments
- Bipolar Disorder and Treatment
- Advanced MRI Techniques and Applications
- Vitamin D Research Studies
- Heart Failure Treatment and Management
- Renal Transplantation Outcomes and Treatments
- Hemodynamic Monitoring and Therapy
- Electrolyte and hormonal disorders
Fresenius Medical Care North America (United States)
2020-2024
Fresenius Medical Care (United States)
2020-2024
University of Augsburg
2024
Indiana University – Purdue University Indianapolis
2005-2021
Bayer (Germany)
2021
Sir Charles Gairdner Hospital
2018
Feuerwehr Dortmund
2017
Indiana University School of Medicine
1996-2016
Indiana University Health
2009-2015
Universität Ulm
2012-2013
Background and Purpose —Besides the delineation of hypoperfused brain tissue, characterization ischemia with respect to severity is major clinical relevance, because degree hypoperfusion most critical factor in determining whether an ischemic lesion becomes infarct or represents viable tissue. CT perfusion imaging yields a set related parameters which might be useful describe hemodynamic status brain. Our objective was determine measurements relative cerebral blood flow (rCBF), volume...
Preformed HLA antibodies (Ab), reported as panel-reactive antibody (PRA), prolong patient waiting time for kidney transplantation. We hypothesized that rituximab (RTX) could reduce PRA via B-cell depletion. This initial study reports the safety, pharmacokinetics, and pharmacodynamics of RTX in patients with end-stage renal failure. The was an investigator-initiated single-dose, dose-escalation phase I trial chronic dialysis (PRA >50%). It approved by Institutional Review Board Food Drug...
The mortality rate for patients with acute renal failure (ARF) remains unacceptably high. Although dialysis removes waste products and corrects fluid imbalance, it does not perform the absorptive, metabolic, endocrine, immunologic functions of normal tubule cells. assist device (RAD) is composed a conventional hemofilter lined by monolayers For testing whether short-term (up to 72 h) treatment RAD would improve survival in ARF compared continuous replacement therapy (CRRT), Phase II,...
To assess the outcome of interventional radiologic placement tunneled hemodialysis catheters via right internal jugular vein.In 194 patients, catheter was placed vein unless thrombosis present. Real-time ultrasound-guided puncture and fluoroscopic guidance were used. Patients followed up until removal or death. Outcomes evaluated included infection, thrombosis, malfunction.In 175 250 consecutive with 100% success. All functioned immediately after placement. Procedural complications limited...
PURPOSE: To determine whether silver-coated tunneled hemodialysis catheters reduce infection and to the frequency of central venous thrombosis stenosis with percutaneous placement right internal jugular vein dialysis by interventional radiologists. MATERIALS AND METHODS: Ninety-one patients were randomly assigned a treatment (silver-coated catheter; n = 47) or control (identical catheter without silver coating; 44) arm. Baseline venography was performed. Catheter tips cultured repeated at...
Restless legs syndrome (RLS) and sleep disturbances are common among in-center hemodialysis patients associated with increased morbidity/mortality.The FREEDOM study is an ongoing prospective cohort investigating the benefits of home short daily (SDHD) (6 times/week). In this interim report, we examine long-term effect SDHD on prevalence severity RLS, as measured by International Legs Syndrome (IRLS) Study Group rating scale, disturbances, Medical Outcomes survey.235 participants were...
Renal replacement therapy (RRT) requirements for critically ill patients with acute renal failure (ARF) depend on numerous factors, including the degree of hypercatabolism, patient size, and desired level metabolic control. However, current practice at many institutions is to prescribe generally similar amounts RRT ARF essentially without regard above factors. In this study, a computer-based model designed permit individualized prescription was developed. The critical input parameter...
PURPOSE: To determine the prevalence of internal jugular vein thrombosis among patients undergoing hemodialysis in whom tunneled dialysis catheters were placed by interventional radiologists and to evaluate potential risk factors for thrombosis, such as number inserted per patient through right vein, catheter type material, total days, catheter-associated infection. MATERIALS AND METHODS: Ultrasonographic (US) evaluation was performed 143 with a history placement. The examination focused on...
Abstract Home hemodialysis has been a therapeutic option for almost 4 decades. The complexity of dialysis equipment factor‐limiting adoption this modality. We performed feasibility study to demonstrate the safety center‐based vs. home‐based daily with NxStage System One portable device. also retrospective analysis determine if clinical effects previously associated short‐daily were seen using novel conducted prospective, 2‐treatment, 2‐period, open‐label, crossover in‐center home in 32...
Abstract: Recent clinical data indicate both ultrafiltration rate (Q f ) and timing of treatment initiation in continuous renal replacement therapy (CRRT) frequency intermittent hemodialysis (HD) influence survival critically ill patients with acute failure (ARF). In this study, kinetic modeling is used to compare effective dose delivery by three dialysis therapies: venovenous hemofiltration (CVVH), daily HD, sustained low‐efficiency (SLED). A modified equivalent clearance (EKR) approach...
Abstract Introduction Inadequate predialysis care and education impacts the selection of a dialysis modality is associated with adverse clinical outcomes. Transitional units (TCUs) aim to meet unmet educational needs incident patients, but their impact beyond increasing home utilization has been incompletely characterized. Methods This retrospective study included adults initiating in‐center hemodialysis at TCU, matched controls (1:4) no TCU history hemodialysis. Patients were followed for...