A5057568411- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mycobacterium research and diagnosis
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Mycology
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- Sarcoidosis and Beryllium Toxicity Research
- Occupational and environmental lung diseases
- Transplantation: Methods and Outcomes
- Air Quality and Health Impacts
- Tracheal and airway disorders
- Asthma and respiratory diseases
- Machine Learning in Healthcare
- Thermal Regulation in Medicine
- Nosocomial Infections in ICU
- Pneumothorax, Barotrauma, Emphysema
- Electronic Health Records Systems
- Neonatal Respiratory Health Research
- Airway Management and Intubation Techniques
- Global Health Care Issues
- Medical Research and Treatments
Seoul National University Hospital
2015-2025
Seoul National University
2017-2024
Ajou University
2020-2022
Boramae Medical Center
2021
New Generation University College
2017-2021
Seoul Metropolitan Government
2021
Yonsei University
2021
Hanyang University Guri Hospital
2021
Hallym University
2021
Pulmonary and Critical Care Associates
2021
Abstract Background Mycobacterium abscessus and massiliense are grouped as the complex. The aim of this study was to elucidate differences between M. lung diseases in terms progression rate, treatment outcome, predictors thereof. Methods Between 1 January 2006 30 June 2015, 56 patients 54 were diagnosed with diseases, respectively. time requiring outcomes compared 2 groups patients, sustained culture conversion analyzed. In addition, mediation analysis performed evaluate effect...
Abstract Purpose Mediastinal nodal staging is crucial for surgical candidate selection in non-small cell lung cancer (NSCLC), but conventional imaging has limitations often necessitating invasive staging. We investigated the additive clinical value of fibroblast activation protein inhibitor (FAPI) PET/CT, an technique targeting protein, mediastinal NSCLC. Methods In this prospective pilot study, we enrolled patients scheduled resection NSCLC based on specific criteria designed to align with...
Neutrophilic inflammation is a prominent feature of chronic obstructive pulmonary disease (COPD). Developmental endothelial locus-1 (Del-1) has been reported to limit excessive neutrophilic by inhibiting neutrophil adhesion the vascular cells. However, effects Del-1 in COPD are not known. We investigated role pathogenesis COPD. protein expression was decreased lungs patients, especially epithelial cells and alveolar macrophages. In contrast human lung tissue, upregulated tissue from mice...
Abstract The progression of idiopathic pulmonary fibrosis (IPF) is assessed through serial monitoring forced vital capacity (FVC). Currently, data regarding the clinical significance longitudinal changes in diffusing for carbon monoxide (DLCO) lacking. We investigated prognostic implications a 1-year decline DLCO 319 patients newly diagnosed with IPF at tertiary hospital between January 2010 and December 2020. Changes FVC over first year after initial diagnosis were reviewed; ≥ 5% 10%...
Recent reports have suggested that pneumonitis is a rare complication following vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, its clinical features and outcomes are not well known. The aim of this study was to identify the characteristics patients with vaccine-associated SARS-CoV-2.In nationwide multicenter survey study, questionnaires were distributed pulmonary physicians in referral hospitals. They asked report cases development or exacerbation...
Purpose To investigate quantitative CT (QCT) measurement variability in interstitial lung disease (ILD) on the basis of two same-day scans. Materials and Methods Participants with ILD were enrolled this multicenter prospective study between March October 2022. underwent scans at an interval a few minutes. Deep learning-based texture analysis software was used to segment features. Fibrosis extent defined as sum reticular opacity honeycombing cysts. Measurement assessed Bland-Altman analyses...
Posterior reversible encephalopathy syndrome (PRES) is a rare complication of lung transplantation with poorly understood risk factors and clinical characteristics. This study aimed to examine the occurrence, factors, data patients who developed PRES following transplantation. A retrospective analysis was conducted on 147 underwent between February 2013 December 2023. The were diagnosed based symptoms radiological findings. We compared baseline characteristics information, including primary...
Sarcoidosis is a granulomatous inflammatory disease of unknown etiology that can affect the entire body, but respiratory tract involvement most common. In radiological findings, bilateral hilar and mediastinal lymph node enlargement common finding, when lung parenchyma involved, findings such as micronodules, ground-glass shadows, reticular fibrosis are seen. Biopsies for histological diagnosis mainly performed on nodes or lungs, biopsies done via endobronchochial ultrasound-guided fine...
Abstract Background and Objective Corticosteroids are commonly used for the treatment of acute exacerbation idiopathic pulmonary fibrosis (AE‐IPF); however, optimal initial dose corticosteroids remains uncertain due to a lack sufficient evidence. We evaluated whether administration pulse resulted in improved survival outcomes compared with conventional non‐pulse corticosteroids. Methods retrospectively analysed 238 patients AE‐IPF treated at tertiary referral hospital between January 2013...
Background Although electronic health records (EHRs) have been widely used in secondary assessments, clinical documents are relatively less utilized owing to the lack of standardized text frameworks across different institutions. Objective This study aimed develop a framework for processing unstructured EHRs and integration with structured data. Methods We developed known as Staged Optimization Curation, Regularization, Annotation (SOCRATex). SOCRATex has following four aspects: (1)...
See commentary "Dexamethasone and COVID-19 in a Developing Country: Appropriate Use?" Volume 84 on page 248.
Background: Exhaled condensates contain inflammatory biomarkers; however, their roles in the clinical field have been under-investigated.Methods: We prospectively enrolled subjects admitted to pulmonology clinics. collected exhaled breath (EBC) and analysed levels of six 12 biomarkers using conventional multiplex enzyme-linked immunosorbent assay, respectively.Results: Among 123 subjects, healthy controls constituted largest group (81 participants; 65.9%), followed by preserved ratio...
Abstract Given the pleiotropic effects of statins beyond their lipid-lowering effects, there have been attempts to evaluate role statin therapy in IPF, but they shown inconclusive results. Data from National Health Insurance Service (NHIS) database South Korea were used investigate on IPF. The IPF cohort consisted a total 10,568 patients who newly diagnosed with between 2010 and 2017. These then matched 1:3 ratio 31,704 subjects control without matching based age sex. A case–control study...
Purpose: COPD is characterized by an accelerated and progressive decline in forced expiratory volume 1 second (FEV ) lung hyperinflation. Although hyperinflation the hallmark of COPD, data on longitudinal changes any association with FEV are lacking. The aim this study was to evaluate investigate its relationship decline. Patients methods: We conducted a prospective cohort studied 176 patients annual measurements over period 5 years or more. used random coefficient model calculate volumes...
Diffuse alveolar damage (DAD) is the histopathologic hallmark of acute respiratory distress syndrome (ARDS). However, there are several non-DAD conditions mimicking ARDS. The purpose this study was to investigate heterogeneity ARDS revealed by surgical lung biopsy and its clinical relevance.
Current guidelines recommend a susceptibility-based regimen for Mycobacterium abscessus subspecies pulmonary disease (MAB-PD), but the evidence is weak. We aimed to investigate association between treatment outcomes and in vitro drug susceptibility injectable antibiotics MAB-PD patients.We enrolled patients treated with intravenous amikacin beta-lactams ≥4 weeks at 4 referral hospitals Seoul, South Korea. Culture conversion microbiological cure 1 year were evaluated based on among those ≥2...
Pulmonary arteriovenous malformations (AVMs) are caused by abnormal vascular communications between the pulmonary arteries and veins, which lead to blood bypassing normal capillary beds. AVMs result in right-to-left shunts, resulting hypoxemia, cyanosis, dyspnea. Clinical signs symptoms vary depending on size, number, flow of AVMs. Transcatheter embolization is treatment choice for However, this method can fail if AVM large or has multiple complex feeding arteries. Surgical resection...