A5100768823- Systemic Lupus Erythematosus Research
- Sepsis Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Eosinophilic Disorders and Syndromes
- Metabolism, Diabetes, and Cancer
- T-cell and B-cell Immunology
- Inflammatory Myopathies and Dermatomyositis
- Cancer Research and Treatment
- Peroxisome Proliferator-Activated Receptors
- interferon and immune responses
- Gut microbiota and health
- Hemodynamic Monitoring and Therapy
- Adipose Tissue and Metabolism
- S100 Proteins and Annexins
- Clostridium difficile and Clostridium perfringens research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Acupuncture Treatment Research Studies
- Psoriasis: Treatment and Pathogenesis
- Diabetes and associated disorders
- Inflammasome and immune disorders
- Adolescent and Pediatric Healthcare
Sichuan University
2017-2024
West China Hospital of Sichuan University
2017-2024
Shanghai Clinical Research Center
2024
Shandong University of Traditional Chinese Medicine
2022
Shanxi University of Traditional Chinese Medicine
2022
Weatherford College
2020
Southampton General Hospital
2004
University of Southampton
2004
Peroxisome proliferator-activated receptor-alpha (PPARalpha) is a key regulator of fatty acid oxidation in skeletal muscle, but few data exist from humans vivo. To investigate whether insulin sensitivity muscle and body mass index (BMI) were associated with expression PPARalpha important genes regulating lipid metabolism vivo, we undertook hyperinsulinemic-euglycemic clamps measured mRNA levels response biopsies. 16 men, using novel highly sensitive specific medium throughput quantitative...
Abstract To investigate and establish a reference interval (RI) of neuron-specific enolase (NSE) in southwest China’s healthy population by using the laboratory information system database. A total 86957 periodic health examination individuals medical center West China Hospital from 2016 to 2018 were included study. We used Box-Cox conversion combined with Tukey method normalize data eliminate outliers, normal distribution nonparametric estimate 95% RI. The NSE RI we established populations...
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with considerable genetic predisposition. Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 (NLRP3) crucial for the innate immunity and implicated in SLE pathogenesis. Accordingly, we conducted case-control study to find association of NLRP3 variations susceptibility activity.Three single nucleotide polymorphisms (rs3806268, rs4612666, rs10754558) were genotyped 400 patients...
Anti-melanoma differentiation-associated gene 5 positive dermatomyositis (MDA5+ DM) is a life-threatening disease due to rapidly progressive interstitial lung (RP-ILD). We aimed investigate the expression profile of T cell subsets in MDA5+ DM patients, seeking for possible disease-causing and potential biomarkers distinguish ILD, especially RP-ILD patients.
To investigate the prognostic significance of N7-methylguanosine (m7G) regulators and immune infiltration in liver hepatocellular carcinoma (LIHC).The research measured predictive m7G genes LIHC samples from The Cancer Genome Atlas (TCGA) International Consortium (ICGC) datasets. Data on stemness index based mRNA expression (mRNAsi), gene mutations, corresponding clinical characteristics were obtained TCGA ICGC. Lasso regression was used to construct prediction model assess signals LIHC....
Objectives Posttransplantation diabetes mellitus ( PTDM ) is a major complication after solid organ transplantation. This study to investigate the association of nine genetic variant factors and in Chinese Han patients. Methods HLA ‐ DP (rs3077, rs9277535), DQ (rs7453920), signal transducer activator transcription 4 STAT 4) (rs7574865), IL ‐28B (rs12979860, rs8099917, rs12980275), ‐18 (rs1946518 rs187238) were investigated 260 liver transplant recipients vs non‐ by high‐resolution melting...
Objective Interleukin-21 (IL-21) contributes to expansion, differentiation, and modulation of various immunocompetent cells. Deregulated production IL-21 plays a role cardinal significance in the pathogenesis systemic lupus erythematosus (SLE). We aimed determine whether single nucleotide polymorphisms (SNP) near gene have significant association with SLE susceptibility T helper-related inflammatory cytokine profile patients. Methods enrolled 460 patients healthy controls. Whole genome...