A5100356327- Renal Transplantation Outcomes and Treatments
- Immune Cell Function and Interaction
- Pharmacological Effects and Toxicity Studies
- T-cell and B-cell Immunology
- Organ Transplantation Techniques and Outcomes
- Inflammasome and immune disorders
- Galectins and Cancer Biology
- Bipolar Disorder and Treatment
- Bone health and osteoporosis research
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- Bone Metabolism and Diseases
- Neurological Complications and Syndromes
- Chronic Kidney Disease and Diabetes
- Cancer-related molecular mechanisms research
- Esophageal Cancer Research and Treatment
- Immunotherapy and Immune Responses
- Autoimmune Bullous Skin Diseases
- Myasthenia Gravis and Thymoma
- Tryptophan and brain disorders
- Organ Donation and Transplantation
- Cytomegalovirus and herpesvirus research
- Transplantation: Methods and Outcomes
- Head and Neck Cancer Studies
- Cardiac Imaging and Diagnostics
Sichuan University
2011-2025
West China Hospital of Sichuan University
2011-2025
Xiangya Hospital Central South University
2020
Central South University
2020
General Hospital of Shenyang Military Region
2016
Nanjing Drum Tower Hospital
2016
Guhua Hospital
2016
Kunming Medical University
2016
First Affiliated Hospital of Kunming Medical University
2016
An increasing amount of evidence suggests that interleukin-18 (IL-18) plays a pivotal role in the pathophysiology schizophrenia. However, association between single nucleotide polymorphism IL-18 and risk schizophrenia has not been clarified. This study examined whether two promoter polymorphisms -137 G/C (rs187238) -607 C/A (rs1946518) were associated with six clinical symptoms (disorder perception, thought disorder, disturbance emotion, disorder behavior volition, suicide action, aggressive...
T follicular helper (Tfh) cells play a control role in contribution of B cell differentiation and antibody production. regulatory (Tfr) inhibit Tfh-B interaction. To identify whether circulating Tfh (cTfh) Tfr (cTfr) contribute to chronic renal allograft dysfunction (CAD), 67 kidney transplant recipients (34 with CAD, 33 stable function) were enrolled. The frequency cTfh cTfr cells, the level serum CXCL13 measured. CAD group was significantly lower than that (0.31% vs 0.68%, P = 0.002)....
BACKGROUND:Tacrolimus is a widely used immunosuppressant in renal transplant recipients. It was demonstrated rats and healthy volunteers that Wuzhi capsules could inhibit metabolism maintain blood concentration of tacrolimus. However, there are no clinical studies This research aimed to assess the effect on tacrolimus MATERIAL AND METHODS:A total 158 Chinese recipients receiving with or without were included this retrospective study. The cohort study 126 recipients, 86 (WZCs) other 40 not...
A pulsed electromagnetic field (PEMF) can promote osteogenesis. However, studies have shown variation in the signal characteristics terms of waveform type, intensity, frequency, and treatment duration. Among factors that affect fields, frequency plays a major role. few investigated effects PEMF at different frequencies osteoporotic mice. Therefore, our objective was to determine effect Forty 3-month-old female mice were randomly divided into following five groups: sham, OVX, OVX followed by...
The association between a single-nucleotide polymorphism (SNP; -607A/C) in the promoter region of IL-18 gene with transcription activity and level protein production has been observed repeatedly. However, IL-18-607A/C (rs1946518) IgA nephropathy (IgAN) Chinese Han population is still unclear. A total 166 patients renal biopsy-proven IgAN 198 healthy controls were recruited for this study. SNP was genotyped by polymerase chain reaction high-resolution melting method. Clinical characteristics...
Tacrolimus (TAC) and mycophenolic acid (MPA) are commonly used immunosuppressive therapies after renal transplant. Our objective was to quantify TAC MPA concentrations in peripheral blood mononuclear cells (PBMCs) using liquid chromatography tandem mass spectrometry (LC-MS/MS) evaluate validate the performance of methodology. A prospective follow-up cohort study conducted determine whether intracellular were associated with adverse outcomes transplants.PBMCs prepared Ficoll separation...
Background: We investigated the correlation between glucose metabolism patterns of different immune cells and metabolic regulatory signaling pathways in myasthenia gravis (MG) aimed to identify therapeutic targets for MG.
Background: Female patients are at higher risk of contrast-induced acute kidney injury (CIAKI) compared to males. In the multicenter, prospective, TRACK-D study, short-term rosuvastatin has proven effectively reduce CIAKI in with type 2 diabetes mellitus and stage 2-3 chronic disease (CKD). This study aimed explore efficacy female population. Methods: was a gender-based analysis 2,998 (1,044 females) enrolled were randomized (2 days before 3 after procedure) therapy or standard care. The...
Aim: To investigate the association between donor CYP3A5 and ABCB1 polymorphisms tacrolimus (Tac)-induced nephrotoxicity renal function in kidney transplant recipients. Methods: The 6986A>G 3435C>T were determined 237 recipients donors. Results: There was no significant Tac-related genotype. polymorphism associated with estimated glomerular filtration rate on day 7 month 1. combined donor–recipient genotype (3435C>T polymorphism) significantly related 3 univariate analysis. However, these...
Objectives Posttransplantation diabetes mellitus ( PTDM ) is a major complication after solid organ transplantation. This study to investigate the association of nine genetic variant factors and in Chinese Han patients. Methods HLA ‐ DP (rs3077, rs9277535), DQ (rs7453920), signal transducer activator transcription 4 STAT 4) (rs7574865), IL ‐28B (rs12979860, rs8099917, rs12980275), ‐18 (rs1946518 rs187238) were investigated 260 liver transplant recipients vs non‐ by high‐resolution melting...
Lymphocyte subsets significantly change during childhood; thus, age-matched reference values derived from healthy children are crucial. We established for lymphocyte subsets, including T cells (CD3+), CD4 (CD3 + CD4+), CD8 CD8+), double negative (DNT) CD4-CD8-), B (CD3-CD19+), NK (CD3-CD56+), and NKT-like CD56+) in the peripheral blood of 813 children. used method international standard document (Clinical Laboratory Standard Institute C28-A3) to establish intervals with a single platform....
BACKGROUND We investigated whether a low fixed Tac starting dose regimen could lead to better achievement of target concentrations, as well an effective immunosuppressive treatment, in Chinese kidney transplant recipients (KTRs). MATERIAL AND METHODS collected whole-blood and serum samples from 189 KTRs the was 2, 2.5, or 3 mg/day. Information on C0, dose, body weight, mass index (BMI), Scr, eGFR, CYP3A5 genotypes were routine therapeutic drug monitoring database. The correlation between C0...
Kidney transplantation is the ideal treatment for end-stage renal disease (ESRD). Chronic antibody-mediated rejection (CAMR) main cause of graft failure. Tfh and B cells are key immune that play important roles in CAMR. In this study, populations different cell phenotypes subsets CAMR were investigated a total 36 patients. Based on Banff-2019, 15 patients diagnosed with (CAMR group), 11 recipients recurrent or de novo IgA nephropathy (IgAN 10 displayed stable function (stable group). The...
To preliminarily describe the epidemiologic and hemodynamic characteristics of critically ill patients with restrictive filling diastolic dysfunction based on echocardiography.A retrospective study.Epidemiologic in ICU were described; clinical data summarized compared between without dysfunction; most echocardiography.More than half had about 16% them pattern. The who more likely to have wider diameter IVC (2.18 ± 0.50 versus 1.92 0.43, P = 0.037), higher extravascular lung water score (15.9...
The roles of PD-1+ CXCR5+ follicular helper CD8+ T cell were reported in different disease conditions, but their transplantation are unclear. In this study, the association between and renal allograft dysfunction kidney transplant recipients (KTRs) was investigated.82 KTRs enrolled study. 45 included chronic (CAD) group, 37 stable group. Among CAD 12 cases antibody-mediated rejection (ABMR) 4 cell-mediated (TCMR) diagnosed by biopsy. percentage cells co-expression signal transducers...