A5059325272- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Multiple Sclerosis Research Studies
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Parkinson's Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Neurological disorders and treatments
- Spinal Fractures and Fixation Techniques
- Systemic Sclerosis and Related Diseases
- Anesthesia and Pain Management
- Peripheral Neuropathies and Disorders
- Functional Brain Connectivity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Spine and Intervertebral Disc Pathology
- Radiation Dose and Imaging
- Amyotrophic Lateral Sclerosis Research
- Bone and Joint Diseases
- NMR spectroscopy and applications
- Infectious Encephalopathies and Encephalitis
- Neurogenetic and Muscular Disorders Research
- Vasculitis and related conditions
- RNA regulation and disease
University of Alberta
2015-2024
Alberta Hospital Edmonton
1999-2023
Deleted Institution
2021-2023
Emery Oleochemicals (Malaysia)
2012-2022
Centre National pour la Recherche Scientifique et Technique (CNRST)
2021
University of British Columbia
1984-2015
University of Calgary
2013-2015
Medical College of Wisconsin
1993-2015
University of Alberta Hospital
1999-2013
University of Ottawa
2013
Subepidermal blistering associated with the human skin diseases bullous pemphigoid and herpes gestationis has been thought to be an IgG autoantibody-mediated process; however, previous attempts demonstrate pathogenicity of patient autoantibodies have unsuccessful. An immunodominant potentially pathogenic epitope these recently mapped extracellular domain a epidermal antigen, BP180. Patient that react this well-defined antigenic site failed crossreact murine form autoantigen thus could not...
Abstract Bullous pemphigoid (BP) and herpes gestationis (HG) are skin diseases characterized by subepidermal blisters autoantibodies against two hemidesmosomal Ag, i.e., BP230 BP180. Based on sequence analysis the BP180 Ag was predicted to be a transmembrane protein with long extracellular collagenous domain. In present investigation fusion proteins encompassing various segments of were expressed in prokaryotic system assayed immunoblotting immunoadsorption panel BP, HG control sera. One...
<h3>Background</h3> Bronchopulmonary dysplasia (BPD) remains a main complication of extreme prematurity and currently lacks efficient treatment. Rat bone marrow-derived mesenchymal stem cells (MSC) prevent lung injury in an oxygen-induced model BPD. Human cord is advantageous source that especially appealing for the treatment neonatal diseases. The therapeutic benefit after established long-term safety cord-derived unknown. <h3>Methods</h3> perivascular (PCs) or blood-derived MSCs were...
Background and Purpose— Acute blood pressure (BP) reduction aimed at attenuation of intracerebral hemorrhage (ICH) expansion might also compromise cerebral flow (CBF). We tested the hypothesis that CBF in acute ICH patients is unaffected by BP reduction. Methods— Patients with spontaneous <24 hours after onset systolic > 150 mm Hg were randomly assigned to an intravenous antihypertensive treatment protocol targeting a <150 (n=39) or <180 (n=36). underwent computed tomography...
Internal carotid artery dissection has been extensively studied and well-described. Although there a recent increase in the number of reported cases vertebral (VA) dissection, clinical variety presentation early warning symptoms have not well-described before. Our objectives this study include: (1) To determine signs which may help clinician identification treatment patients with VA dissection. (2) explore its relation to prognosis.Retrospective analysis hospital records tertiary academic...
To investigate the relationship between iron staining and magnetic resonance (MR) imaging measurements in postmortem subjects with multiple sclerosis (MS).Institutional ethical approval was obtained, informed consent obtained from and/or their families. Four MR methods based on transverse relaxation (T2 weighting, R2 mapping, R2* mapping) phase were performed by using a 4.7-T system three situ patients MS less than 28 hours after death one vivo patient 1 year before death. Iron Perls...
Diffusion-weighted imaging (DWI) of tissue water is a sensitive and specific indicator acute brain ischemia, where reductions the diffusion are observed acutely in stroke lesion core. Although these changes have been long attributed to cell swelling, precise nature biophysical mechanisms remains uncertain.The potential cause after was investigated using an advanced DWI technique, oscillating gradient spin-echo DWI, that enables much shorter times can improve specificity for alterations...
Multiple sclerosis (MS) lesion evolution may involve changes in diamagnetic myelin and paramagnetic iron. Conventional quantitative susceptibility mapping (QSM) can provide net distribution, but not the discrete components.
To investigate the relationship between magnetic resonance (MR) imaging markers of iron content and disease severity in patients with multiple sclerosis (MS) over a 2-year period.This prospective study was approved by local ethics committee, written informed consent obtained from all participants. Seventeen MS 17 control subjects were examined twice, 2 years apart, using phase transverse relaxation (R2*) mapping at 4.7 T. Quantitative differences deep gray matter evaluated repeated-measures...
Transient ischemic attack and minor stroke are associated with high recurrence in the first week. We prospectively studied correlation between baseline diffusion/perfusion deficits development of new lesions.Patients transient those (n=50) underwent MRI at admission. Acute perfusion-weighted imaging deficit (Tmax+2-second delay) diffusion-weighted (DWI) lesion volumes were measured planimetrically. Follow-up scans examined for DWI/fluid-attenuated inversion recovery lesions Days 7...
Purpose To follow the evolution of intracranial hemorrhage (ICH) by using quantitative susceptibility mapping (QSM). Materials and Methods Thirty-six patients with ICH confirmed at CT were enrolled to on day 2, 7, 30 after symptom onset between August 2013 April 2017. QSM was reconstructed from MRI gradient-echo phase images acquired 1.5 T or 3.0 T. regions manually drawn two-dimensional sections co-registered MR independently two raters. The areas mean values compared Bland-Altman plots...
Purpose To investigate gradient‐echo phase errors caused by intracranial hemorrhage (ICH) of low signal magnitude, and propose methods to reduce artifacts from in quantitative susceptibility mapping (QSM) ICH. Methods Two QSM are proposed: (1) mask‐inversion that masks the magnitude regions, (2) ICH magnetic dipole field isolation followed superposition using multiple boundaries for background removal. The reconstruction were tested eight subjects with standard single‐echo...
Diffusion-weighted imaging (DWI) lesions have been identified both inside and outside the perihematoma region. We tested hypotheses that larger hematoma volumes blood pressure reduction are associated with DWI lesions.Hematoma edema were measured using planimetric techniques in 117 intracerebral hemorrhage (ICH) patients who underwent DWI. Perihematoma remote lesion apparent diffusion coefficient thresholds for moderate (<730×10(-6) mm/s) severe (<550×10(-6) ischemia. Acute change over first...
Excessive wait times for magnetic resonance imaging (MRI) studies are a major problem in the Canadian healthcare system. To determine how requests MRI managed, authors performed survey of public facilities Canada. Ninety-six per cent had some method to triage requests. However, only 42% documented guidelines prioritization, and none employed quality assurance methods ensure that were followed. Target timelines each prioritization category varied widely. Sixteen centres not able meet their...
Abstract Age‐related ventricular enlargement is accelerated in Alzheimer's disease, but its relationship to cognitive decline Parkinson's disease less clear, even though dementia common disease. Our goals were determine if greater of the ventricles and gray or white matter atrophy occurred patients developing decline. Older nondemented with (33) age‐ sex‐matched controls (39) recruited prospectively assessed for development significant over 36 months. Magnetic resonance imaging was obtained...
Key points Abnormal activation of motoneurons in the spinal cord by sensory pathways is thought to contribute impaired movement control and spasticity individuals with cerebral palsy. Here we use single motor unit recordings show how individual respond inputs a group participants palsy having different degrees dysfunction. In who had problems walking independently required assistive devices such as wheelchairs, only excited cord. contrast, walked for long distances, both inhibited cord,...
<b>Objective:</b> To study the short and long term differences in outcome between patients ⩾80 years of age those ⩽79 who received intravenous recombinant tissue plasminogen activator (iv rt-PA) for acute stroke within first 3 hours symptom onset. <b>Methods:</b> We studied consecutive treated with iv rt-PA stroke, prospective follow up to years. Outcome measures included National Institutes Health Stroke Scale (NIHSS) score, Barthel Index (BI), modified Rankin score (MRS), mortality....