A5062501802- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Monoclonal and Polyclonal Antibodies Research
- Platelet Disorders and Treatments
- Receptor Mechanisms and Signaling
- Mast cells and histamine
- Cell Adhesion Molecules Research
Wenzhou Medical University
2025
Medical College of Wisconsin
1993-2017
University of North Carolina at Chapel Hill
2001
Subepidermal blistering associated with the human skin diseases bullous pemphigoid and herpes gestationis has been thought to be an IgG autoantibody-mediated process; however, previous attempts demonstrate pathogenicity of patient autoantibodies have unsuccessful. An immunodominant potentially pathogenic epitope these recently mapped extracellular domain a epidermal antigen, BP180. Patient that react this well-defined antigenic site failed crossreact murine form autoantigen thus could not...
Abstract Bullous pemphigoid (BP) and herpes gestationis (HG) are skin diseases characterized by subepidermal blisters autoantibodies against two hemidesmosomal Ag, i.e., BP230 BP180. Based on sequence analysis the BP180 Ag was predicted to be a transmembrane protein with long extracellular collagenous domain. In present investigation fusion proteins encompassing various segments of were expressed in prokaryotic system assayed immunoblotting immunoadsorption panel BP, HG control sera. One...
Bullous pemphigoid (BP) is an inflammatory subepidermal blistering disease associated with IgG autoimmune response to the hemidesmosomal protein BP180. Passive transfer of antibodies murine BP180 (mBP180) ectodomain triggers a skin in mice that depends on complement activation and neutrophil infiltration closely mimics human BP. In present study, we show mast cells (MCs) play crucial role experimental Wild-type injected intradermally pathogenic anti-mBP180 exhibited extensive MC...
Bullous pemphigoid (BP) and herpes gestationis (HG) are subepidermal blistering diseases associated with an autoimmune response directed against BP180, epidermal hemidesmosomal glycoprotein. The pathogenic relevance of this Ag/Ab system was established by the recent demonstration that IgG Abs reactive murine form BP180 (mBP180) capable triggering a disease after passive transfer into neonatal BALB/c mice. aim present study to determine fine specificity pathogenically relevant in experimental...
This study assessed the potential of lncRNA LINC01184 in predicting PTC progression and prognosis its regulatory mechanism cellular processes, aiming to explore a novel biomarker for PTC. The enrolled 111 patients collected paired tissue samples. Using PCR, expression was analyzed, association with patients' clinicopathological features evaluated. effects on cell growth metastasis were by CCK8 Transwell assays. significantly downregulated PTC, which closely correlated poor differentiation,...