Poor medication adherence contributes to negative treatment response, symptom relapse, and hospitalizations in schizophrenia. Many health plans use claims-based measures like possession ratios or proportion of days covered (PDC) measure patient antipsychotics. Classifying patients solely on the basis a single average PDC measure, however, may mask clinically meaningful variations over time how arrive at an level.

This study characterized the costs of multiple myeloma (MM) during first-line (1L), second-line (2L) and third-line (3L) treatment from US payer perspective. Patients with ≥2 outpatient or ≥1 inpatient claims a primary MM diagnosis 12 months continuous enrollment post index were identified in retrospective database between 1 July 2006 30 June 2013. A cost per-patient per-month (PPPM) metric was used to calculate total all-cause anti-MM pharmacy 1L, 2L, 3L treatment. Of 5704 patients...

To estimate the utilization of U.S. Food and Drug Administration- approved prescription antiobesity medications (AOMs) to identify factors associated with AOM use in United States.Respondents aged ≥18 years meeting eligibility criteria 2015-2016 2017-2018 National Health Nutrition Examination Survey 2016 Medical Expenditure Panel were included study. was defined as having a body mass index (BMI) ≥30 kg/m2 or BMI between 27 29.9 at least 1 obesity-related comorbidity. Demographic,...

Background: Prevalence estimates of primary biliary cholangitis (PBC) in the United States have evolved with introduction newer real-world data capture approaches. Little is known about geographic distribution PBC and health care provider (HCP) landscape for patients PBC. This study aimed to estimate prevalence States, assess regional variability its prevalence, describe HCPs Methods: Patients were identified using Komodo's Healthcare Map, a large national administrative claims database. per...

Abstract Over the past five decades in United States, total medical expenditures and proportion of financed with public funds have both increased significantly. A substantial increase prevalence obesity has contributed to this growth. In study we measure external cost form publicly funded health‐care expenditures, how changes when distribution population changes. We use a continuous obesity, Body Mass Index (BMI), rather than discrete BMI categories represent it. predict that one‐unit for...

This study analyzed hospital readmission rates of patients with schizophrenia who were treated long-acting injectable antipsychotics (LAIs) or oral after being discharged from a hospitalization.Medical claims ages 18-64 and had first hospitalization for serious mental illness (index hospitalization, October 2007 through September 2012) at least one prescription first- second-generation antipsychotic the Truven Health MarketScan Multi-State Medicaid Database. Analyses conducted sole diagnosis...

Mental health comorbidities are commonplace among patients with cancer and have been associated adverse outcomes elevated care costs. Given the rapidly evolving landscape, an updated understanding of prevalence costs mental conditions is needed. This study assessed incremental anxiety depression Medicare beneficiaries cancer.This retrospective cohort used SEER-Medicare database. Patients diagnosed melanoma, breast, lung, prostate, or colorectal between July 2013 December 2017 were followed...

Aim: To evaluate the clinical characteristics and healthcare resource utilization for acute care its costs patients with primary biliary cholangitis (PBC) or without cirrhosis. Materials & methods: This retrospective observational cohort study was conducted using two datasets (Komodo's Healthcare Map™ [Komodo Health] Optum Clinformatics® Data Mart [CDM] database) between 2015 2023. Patients (≥18 years) PBC were identified based on ≥1 inpatient ≥2 outpatient claims. (hospitalizations...

Elevated liver biochemistries are associated with increased risk of negative outcomes in patients primary biliary cholangitis (PBC). To evaluate whether longitudinal monitoring and fibrosis scores provides additional prognostic value to assess the relationship between degree elevation multiple biomarkers within different alkaline phosphatase (ALP) strata. Adults PBC were identified from Komodo's Healthcare Map. A Cox proportional hazards model examined time first occurrence hospitalisation...

e16427 Background: Clinical trials have traditionally limited enrollment to patients with ECOG Status 0-1, representing relatively better prognosis and ability tolerate treatment (i.e., performance status). There has been debate about expanding 0-2 serve poorer health status more accurately reflect real world clinical practice. Methods: We conducted an AI-enhanced literature review in pancreatic gastric cancer test whether the primary outcomes, median progression free survival (PFS), overall...

Health care spending and health outcomes vary markedly across countries, but the association between remains unclear. This inevitably raises questions as to whether continuing growth in is justified, especially relative rising cost of cancer care. We compared sixteen countries over time, examining changes two measures mortality (amenable excess mortality). found that low-spending systems, high-spending systems had consistently lower period 1995–2007. Similarly, we increased most a 17 percent...

IMPORTANCE Surrogate end points may be used as proxy for more robust clinical points.One prominent example is the use of progression-free survival (PFS) a surrogate overall (OS) in trials oncologic treatments.Decisions based on expedite regulatory approval but not accurately reflect drug efficacy.Payers and clinicians must balance potential benefits earlier treatment access against risks uncertainty.OBJECTIVE To present framework evaluating expected net benefit or cost providing early to new...

The global obesity epidemic reflects increases in caloric consumption from food and reduced energy expenditure at work. Many factors have contributed to the epidemic, including changes technology (e.g., innovations on farms processing products), lifestyles, women's wages employment. Public health insurance externalities might justify government intervention, but policy record is mixed, with no great success stories date. Well-directed taxes calories, sugar, or fat be economically efficient...

Aims: To determine the cost-effectiveness of treatment sequences biologic disease-modifying anti-rheumatic drugs or Janus kinase/STAT pathway inhibitors (collectively referred to as bDMARDs) vs conventional DMARDs (cDMARDs) from US societal perspective for patients with moderately severely active rheumatoid arthritis (RA) inadequate responses cDMARDs.Materials and methods: An individual patient simulation model was developed that assesses impact treatments on disease based clinical trial...

Brentuximab vedotin (BV) monotherapy (BV-M) and combination (BV-C) therapies are safe effective for classical Hodgkin lymphoma (cHL) CD30-expressing peripheral T-cell lymphomas (PTCLs). Although the sample sizes have been small (12–29 patients), in clinical studies, response rates of 53–88% reported BV retreatment patients with an initial response. We evaluated real-world characteristics treatment patterns cHL/PTCL who received were retreated United States. Symphony Health Patient Claims...

Patients with mental and physical health conditions are complex to treat often use multiple medications. It is unclear how adherence one medication predicts others. A predictive relationship could permit less expensive monitoring if overall be predicted through tracking a single medication.To test this hypothesis, we examined whether patients illnesses have similar trajectories across Specifically, conducted retrospective cohort analysis using insurance claims data for enrollees who were...

We estimate a demand system for ten nonalcoholic beverages to disentangle effects of prices, expenditures, advertising, and demographics on 1999 through 2010. find that changes in demographic composition the population between 2008 played much bigger role observed purchasing patterns recently introduced like soy, rice, almond drinks, isotonic energy bottled water whereas prices advertising expenditures largely explained declining milk, regular carbonated soft coffee tea. However, 2010, most...

Background. Value assessments and treatment decision making typically focus on clinical endpoints, especially overall survival (OS). However, OS data are not always available, surrogate markers may also have some value to patients. This study sought estimate preferences for progression-free (PFS) relative in metastatic breast cancer (mBC) among a diverse set of stakeholders-patients, oncologists, oncology nurses-and the patients providers place other attributes treatment. Methods. Utilizing...

Background. Traditional approaches to capturing health-related productivity loss (e.g., the human capital method) focus only on foregone wages of affected patients, overlooking losses caregivers can incur. This study estimated burden among breast cancer (BC) and non-small-cell lung (NSCLC) patients individuals caring for such using an augmented multiplier method. Design. A cross-sectional survey BC NSCLC measured associated with time absent from work (absenteeism) reduced effectiveness...

Abstract Objectives This study aimed to estimate clinical, economic (including productivity), and health‐related quality of life (HRQoL) outcomes associated individual characteristics among adults with overweight (OW) or obesity in the United States. Methods included adult respondents body mass index (BMI) ≥18.5 kg/m 2 2017–2018 National Health Nutrition Examination Survey (NHANES) 2016 Medical Expenditure Panel Survey. Respondents were classified according BMI. Individual described by BMI...

To estimate the extent to which approvals of new pharmacological therapies were associated with cancer mortality in USA between 2000 and 2016.The analysis quantified drug across 15 tumor types highest incidence. Number a given time period for each was translated into treatment stock measure, defined as weighted sum indication since 1976. The primary outcome annual tumor-specific mortality, number deaths per 100,000 U.S. population. used multivariable ordinary least squares fixed effects...