A5100671148- Plant-Microbe Interactions and Immunity
- Streptococcal Infections and Treatments
- Plant Pathogens and Fungal Diseases
- Microbial infections and disease research
- Plant Stress Responses and Tolerance
- Plant pathogens and resistance mechanisms
- Fungal and yeast genetics research
- Photosynthetic Processes and Mechanisms
- Vector-borne infectious diseases
- CRISPR and Genetic Engineering
- Animal Disease Management and Epidemiology
- Fungal Infections and Studies
- Plant Molecular Biology Research
- Vector-Borne Animal Diseases
- Gastric Cancer Management and Outcomes
- Plant Gene Expression Analysis
- Hepatitis C virus research
- Lung Cancer Treatments and Mutations
- Plant tissue culture and regeneration
- Plant nutrient uptake and metabolism
- Ion Transport and Channel Regulation
- Plant Pathogenic Bacteria Studies
- Phytochemicals and Antioxidant Activities
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
Beijing University of Technology
2016-2025
Harbin Medical University
2022-2025
Fourth Affiliated Hospital of Harbin Medical University
2022-2025
Affiliated Hospital of Shaanxi University of Chinese Medicine
2021-2025
Qingdao Agricultural University
2018-2024
Anhui Normal University
2024
Guangdong Pharmaceutical University
2023
Liaocheng People's Hospital
2022
New Hope Liuhe (China)
2021-2022
Huazhong Agricultural University
2014-2020
The necrotrophic fungal plant pathogen Sclerotinia sclerotiorum is responsible for substantial global crop losses annually resulting in localized food insecurity and loss of livelihood. Understanding the basis this broad-host-range aggressive pathogenicity hampered by quantitative nature both host resistance virulence. To improve understanding, methods efficient functional gene characterization that build upon existing complete S. genome sequence are needed. Here, we report on development a...
Pathogens utilize a panoply of effectors to manipulate plant defense. However, despite their importance, relatively little is actually known about regulation these virulence factors. Here, we show that the effector Fol -Secreted Virulence-related Protein1 (FolSvp1), secreted from fungal pathogen Fusarium oxysporum f. sp. lycopersici ( ), directly binds and translocates tomato pathogenesis-related protein1, SlPR1, apoplast outside plasma membrane host nucleus via its nuclear localization...
The sclerotium, a multicellular structure composed of the compact aggregation vegetative hyphae, is critical for long-term survival and sexual reproduction plant-pathogenic fungus Sclerotinia sclerotiorum. development carpogenic germination sclerotia are regulated by integrating signals from both environmental endogenous processes. Here, we report regulatory functions S. sclerotiorum GATA-type IVb zinc-finger transcription factor SsNsd1 in these orthologous to Aspergillus nidulans NsdD...
Pathogens utilize secretory effectors to manipulate plant defense. Fusarium oxysporum f. sp. lycopersici (Fol) is the causal agent of wilt disease in tomatoes. We previously identified 32 secreted effector candidates by LC-MS analysis. In this study, we functionally one proteins, FolAsp, which belongs aspartic proteases (Asp) family. The FolAsp was upregulated with host root specifically induction. Its N-terminal 1-19 amino acids performed secretion activity yeast system, supported its Fol....
Abstract Studying plant early immunity, such as the unique immune mechanisms against pathogens, is an important field of research. Tomato wilt resulting from infection by Fusarium oxysporum f. sp. lycopersici ( Fol ) soil-borne vascular disease. In this study, we challenged tomato plants with for a time-course RNA sequencing (RNA-seq) analysis. The result indicated that phenylpropanoid and flavonoid pathway genes were significantly enriched during invasion stage. Further study revealed...
Many heavy metals are essential for metabolic processes, but toxic at elevated levels. Metal tolerance proteins provide resistance to this toxicity. In study, we identified and characterized a metal-associated protein, AcHMA1, from the halophyte, Atriplex canescens. Sequence analysis has revealed that AcHMA1 contains two metal binding domains. Treatments with (Fe, Cu, Ni, Cd or Pb), PEG6000 NaHCO3 highly induced expression in A. canescens, whereas NaCl low temperature decreased its...
The objective of this research is to statistically assess the risk cardiovascular mortality (CVM) between patients with small bowel adenocarcinoma (SBA) and general population. Additionally, it aims identify CVM-associated factors among individuals SBA. Data obtained 2000 2017 on SBA from Surveillance, Epidemiology, End Results (SEER) database were examined. Standardized ratios (SMRs) absolute excess risks (AERs) compare CVM US To evaluate cumulative (CM) rate for all causes death (COD),...
Sclerotinia sclerotiorum is a challenging agricultural pathogen for management, causing large global economic losses annually. The sclerotia and infection cushions are critical its long-term survival successful penetration on wide spectrum of hosts. mitogen-activated protein kinase (MAPK) cascades serve as central signaling complexes that involved in various aspects development infection. In this study, the putative downstream transcription factor MAPK pathway, SsSte12, was analyzed S....
Erysipelothrix rhusiopathiae is the causative agent of animal erysipelas and human erysipeloid. Previous studies suggested glyceraldehyde 3-phosphate dehydrogenase (GAPDH) plays a role in pathogenesis E. infection. We studied GAPDH interactions with pig vascular endothelial cells, fibronectin, plasminogen. Recombinant (rGAPDH) was successfully obtained, it shown that adhesion to cells. Moreover, rGAPDH could bind fibronectin plasminogen dose-dependent manner. To our knowledge, this first...
Two-dimensional (2D) ferroelectric field-effect transistors (Fe-FETs) based on p–n junctions are the basic units of future neuromorphic hardware. The In2Se3 semiconductor with ferroelectric, photoelectric, and phase transition properties possesses great application potential for in-sensor computing, but its junction (FePNJ) is not well investigated. Here, we present an optoelectronic synapse made uniformly full-coverage α-In2Se3/WSe2 FePNJ, achieving ultralow-power classification recognition...
Fusarium oxysporum f. sp. lycopersici (Fol) is the causal agent of wilt disease in tomato. Proteins secreted by this pathogen during initial host colonization largely determine outcome pathogen-host interactions. Lysine acetylation (Kac) plays a vital role functions many proteins, but little known about Kac Fol proteins. In study, we analyzed lysine entire secretome. Using high affinity enrichment peptides and LC-MS/MS analysis, 50 potentially proteins were identified sites determined....
GATA transcription factors (TFs) are common eukaryotic regulators, and glutathione-dependent formaldehyde dehydrogenases (GD-FDH) ubiquitous enzymes with detoxification activity. In this study, the dehydrogenase Sclerotinia sclerotiorum Fdh1 (SsFdh1) was first characterized as an interacting partner of a TF, SsNsd1, in S. Genetic analysis reveals that SsFdh1 functions detoxification, nitrogen metabolism, sclerotium development, pathogenicity. Both SsNsd1 harbor typical zinc finger motifs...
The sharing of pathological data is utmost importance in various applications such as remote diagnosis, graded illness treatment, and specialist system development. However, ensuring reliable, secure, privacy-preserving, efficient pose significant challenges. This paper presents a novel solution that leverages blockchain technology to ensure reliability sharing. Additionally, it employs conditional proxy re-encryption (C-PRE) public key encryption with equality test control the scope...
Plant productivity is limited by salinity stress, both in natural and agricultural systems. Identification of salt stress-related genes from halophyte can provide insights into mechanisms stress tolerance plants. Atriplex canescens a xero-halophyte that exhibits optimum growth the presence 400 mM NaCl. A cDNA library derived highly salt-treated A. plants was constructed based on yeast expression system. total 53 transgenic clones expressing enhanced were selected 10⁵ transformants. Their...