A5038540288- Nerve injury and regeneration
- Electrospun Nanofibers in Biomedical Applications
- Spinal Cord Injury Research
- Silk-based biomaterials and applications
- Tissue Engineering and Regenerative Medicine
- Nerve Injury and Rehabilitation
- Viral Infectious Diseases and Gene Expression in Insects
- 3D Printing in Biomedical Research
- Cerebral Palsy and Movement Disorders
- Neurogenesis and neuroplasticity mechanisms
- Advanced Drug Delivery Systems
- Periodontal Regeneration and Treatments
- Endometriosis Research and Treatment
- Wound Healing and Treatments
- RNA Interference and Gene Delivery
- Traumatic Brain Injury Research
- Congenital heart defects research
- Graphene and Nanomaterials Applications
- Conducting polymers and applications
- Silkworms and Sericulture Research
- Nanoparticle-Based Drug Delivery
- Spinal Dysraphism and Malformations
- Gold and Silver Nanoparticles Synthesis and Applications
- Laser Applications in Dentistry and Medicine
- Collagen: Extraction and Characterization
Tehran University of Medical Sciences
2016-2025
Children's Medical Center
2020-2024
University of Tehran
2024
Smith College
2018
Syracuse University
2018
University of Memphis
2018
Texas A&M University
2018
Louisiana State University Health Sciences Center New Orleans
2018
The University of Texas at San Antonio
2018
University of Kentucky
2018
Replacement of peripheral nerve autografts with tissue engineered grafts will potentially resolve the lack especially in patients severe concomitant soft injuries. This study attempted to fabricate a graft composed electrospun PCL conduit filled collagen-hyaluronic acid (COL-HA) sponge different COL-HA weight ratios including 100:0, 98:2, 95:5 and 90:10. The effect HA addition on porosity, mechanical properties, water absorption degradation rate was assessed. A good cohesion between...
Abstract This study was designed to develop a drug delivery system based on poly(N‐isopropylacrylamide) (pNIPAM) hydrogel and suitable solvent enhance solubility local release of curcumin. pNIPAM synthesized by radical polymerization. The chemical, mechanical physical properties biocompatibility were investigated as an implantable rechargeable reservoir. Curcumin loaded within during swelling using two different solvents; methanol, organic solvent, low molecular weight polyethylene glycol...
Abstract Despite recent advancements in peripheral nerve regeneration, the creation of conduits with chemical and physical cues to enhance glial cell function support axonal growth remains challenging. This study aimed assess impact electrical stimulation (ES) using a conductive conduit on sciatic regeneration rat model transection injury. The involved fabrication silk fibroin Au nanoparticles (AuNPs). Collagen hydrogel loaded green fluorescent protein (GFP)-positive adipose-derived...
Neurodegenerative diseases affect many people worldwide, and as the population ages, incidence of these conditions increases. Alzheimer's disease (AD) Parkinson's (PD) are most prevalent neurodegenerative disorders worldwide. Different medicines being used to control symptoms related conditions, but no treatment has yet been approved. Both genetic environmental factors involved in pathogenesis, research on pathophysiological pathways is still ongoing. The role subcellular dysregulation RNA...
Abstract The peripheral nerve regeneration is still one of the major clinical problems, which has received a great deal attention. In this study, electrospun silk fibroin (SF)/poly(ethylene oxide) (PEO) nanofibrous scaffolds were fabricated and functionalized their surfaces with laminin (LN) without chemical linkers for potential use in tissue engineering. morphology, surface chemistry, thermal behavior wettability examined to evaluate performance by means scanning electron microscopy (SEM),...
Abstract Peripheral nerve repair is still one of the major clinical challenges which has received a great deal attention. Nerve tissue engineering novel treatment approach that provides permissive environment for neural cells to overcome constraints repair. Conductivity and interconnected porosity are two required characteristics scaffold be effective in regeneration. In this study, we aimed fabricate conductive with controlled using polycaprolactone (PCL) chitosan (Chit), FDA approved...
In order to regenerate myocardial tissues with functional characteristics, we need copy some properties of the myocardium, such as its extracellular matrix and electrical conductivity. this study, synthesized nanosheets Molybdenum disulfide (MoS2), integrated them into polycaprolactone (PCL) electrospun on surface decellularized human amniotic membrane (DHAM) purpose improving scaffolds mechanical For in vitro studies, seeded mouse embryonic cardiac cells, Embryonic Cardiac Cells (mECCs),...
Abstract Microtubule‐stabilizing agents (MSAs), until now, have primarily been considered for their anti‐proliferative effects in the setting of cancer. However, recent studies revealed that one particular MSA, epothilone B (EpoB), can promote axonal regeneration after traumatic spinal cord injuries (SCI) even presence inhibitor molecules such as neurite outgrowth inhibitor‐A (Nogo‐A). On basis importance having an efficient motor neuron (MN) differentiation protocol stem cell therapy and...
Abstract Spinal cord regeneration is limited due to various obstacles and complex pathophysiological events after injury. Combination therapy one approach that recently garnered attention for spinal injury (SCI) recovery. A composite of three-dimensional (3D) collagen hydrogel containing epothilone B (EpoB)-loaded polycaprolactone (PCL) microspheres (2.5 ng/mg, 10 40 ng/mg EpoB/PCL) were fabricated optimized improve motor neuron (MN) differentiation efficacy human endometrial stem cells...
In tissue engineering, natural hydrogel scaffolds gained considerable attention due to their biocompatibility and similarity macromolecular-based components in the body. However, low mechanical strength high degradation degree limit biomedical application. By varying composition of hydrogels, biochemical properties can be improved. this study, stability fibrin collagen hydrogels composites with decellularized Wharton’s jelly extract (DEWJ) was improved using proanthocyanidin (PA) as a...