A5100690645- Nerve injury and regeneration
- Spinal Cord Injury Research
- Electrospun Nanofibers in Biomedical Applications
- Neurogenesis and neuroplasticity mechanisms
- Silk-based biomaterials and applications
- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Nerve Injury and Rehabilitation
- Wound Healing and Treatments
- Silkworms and Sericulture Research
- Tissue Engineering and Regenerative Medicine
- Hydrogels: synthesis, properties, applications
- Bone Tissue Engineering Materials
- Neurogenetic and Muscular Disorders Research
- Collagen: Extraction and Characterization
- Diabetes Management and Research
- Graphene and Nanomaterials Applications
- Cervical and Thoracic Myelopathy
- Curcumin's Biomedical Applications
- Diabetes and associated disorders
- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Electrohydrodynamics and Fluid Dynamics
- Orthopaedic implants and arthroplasty
- Stroke Rehabilitation and Recovery
Tehran University of Medical Sciences
2014-2025
University of Tehran
2023
Iran University of Medical Sciences
2019
Abstract Compared to the peripheral nervous system, in central system (CNS) disorders, neurons are less able regenerate and reconstruct neural tissue. Tissue engineering is considered as a promising approach for regeneration restoring neurologic function after CNS injuries. Nanofibrous hydrogels have been recently used three‐dimensional (3D) scaffolds tissue applications. In this kind of composites, incorporated with fibers enhance their poor mechanical properties. Furthermore, introducing...
A hybrid hydrogel was obtained from decellularized extract Wharton's jelly (DEWJ) and silk fibroin (SF) characterized for cartilage tissue engineering. used due to its similarity with articular in extracellular matrix composition. Also, has good mechanical properties which make this construct appropriate repair. Decellularization of verified by DAPI staining, DNA quantification, PCR analysis. Then, the biochemical composition DEWJ determined ELISA kits total proteins, collagens, sulfated...
The significant consequences of spinal cord injury (SCI) include sensory and motor disability resulting from the death neuronal cells axon degeneration. In this respect, overcoming SCI including recovery functions is considered to be a difficult tasks that requires attention multiple aspects treatment. breakthrough in tissue engineering through integration biomaterial scaffolds stem has brought new hope for treatment SCI. present study, human endometrial (hEnSCs) were cultured with Schwann...
Abstract Oligodendrocyte (OL) loss and demyelination occur after spinal cord injury (SCI). Stimulation of remyelination through transplantation myelinating cells may be effective in improving function. For the repair strategy to successful, selection a suitable cell maintaining growth when are injected directly site is important. In addition selecting type cell, fibrin hydrogel was used as tissue engineering scaffold for this purpose. To test relationship between myelination functional...
Abstract Human endometrial stem cells (hEnSCs) that can be differentiated into various neural cell types have been regarded as a suitable population for tissue engineering and regenerative medicine. Considering different interactions between hormones, growth factors, other factors in the system, several differentiation protocols proposed to direct hEnSCs towards specific cells. The 17β‐estradiol plays important roles processes of development, maturation, function nervous system. In present...
Mesenchymal stem cell (MSC) derived exosomes (MSC-DE) have been demonstrated to be potential candidates for the treatment of rat spinal cord injury (SCI).
This study aimed to evaluate the effect of nanoparticles based on PLGA and biomolecule lycopene (i.e. NLcp) exosomes loaded hydroxyapatite/collagen-based scaffolds (HA/Coll), human endometrial MSCs (hEnMSCs) differentiation into osteoblast cells. To this end, after synthesizing NLcp isolating hEnMSC-derived exosomes, studying their characterizations, HA/Coll scaffold with/without exosome was fabricated. In following, rat skull-defect model created 54 male Sprague–Dawley rats (12 weeks old)...
Abstract Microtubule‐stabilizing agents (MSAs), until now, have primarily been considered for their anti‐proliferative effects in the setting of cancer. However, recent studies revealed that one particular MSA, epothilone B (EpoB), can promote axonal regeneration after traumatic spinal cord injuries (SCI) even presence inhibitor molecules such as neurite outgrowth inhibitor‐A (Nogo‐A). On basis importance having an efficient motor neuron (MN) differentiation protocol stem cell therapy and...
In tissue engineering, natural hydrogel scaffolds gained considerable attention due to their biocompatibility and similarity macromolecular-based components in the body. However, low mechanical strength high degradation degree limit biomedical application. By varying composition of hydrogels, biochemical properties can be improved. this study, stability fibrin collagen hydrogels composites with decellularized Wharton’s jelly extract (DEWJ) was improved using proanthocyanidin (PA) as a...
Abstract Spinal cord regeneration is limited due to various obstacles and complex pathophysiological events after injury. Combination therapy one approach that recently garnered attention for spinal injury (SCI) recovery. A composite of three-dimensional (3D) collagen hydrogel containing epothilone B (EpoB)-loaded polycaprolactone (PCL) microspheres (2.5 ng/mg, 10 40 ng/mg EpoB/PCL) were fabricated optimized improve motor neuron (MN) differentiation efficacy human endometrial stem cells...
Background: Spinal cord injury (SCI) is a severe neurological disease leading to poor quality of life. Objectives: The regenerative effect adipose-derived mesenchymal stem cells (AD-MSCs) encapsulated into fibrin, and collagen hydrogel scaffolds on rat model SCI was investigated using clinical histopathological examinations. Methods: A total 18 adult male Wistar rats (250 - 300 g) were prepared randomly divided three equal groups, each with six rats, including the control or group (SCI...
One of the most common tools for fabricating different drug-loaded polymeric particles is magnetic stirrer, a widely-used tool in nano-based drug delivery systems. Typically, revolutions per minute (rpm) or G-Force stirrer are reported related literature, while other parameters generate less attention and must be better understood. Reporting rpm likely insufficient producing same vortex flow intensity mono-dispersity as having reliable reproducible nanoparticle microparticle synthesis...
Type 1 diabetes is a metabolic disorder caused by the loss or dysfunction of β-cells in pancreas. Organ shortage critical concern diabetic patients need beta islet transplantation. Tissue engineered islets are promising alternatives to traditional organ Recent progress stem cell biology and gene cloning techniques has raised hopes for generation insulin producing cells (IPCs) without immunosuppression. The purpose this study was produce IPCs using human adipose-derived (hADSCs)...
In the present study , a novel method for production of silk nano fibers are presented . this way mechanical and easy technique is used instead toxic costly chemical methods Also separation from cocoon was carried out by homogenizer probe ultrasonic After preparation nanofibers product characterized Fourier transform infrared spectroscopy (FT - IR) scanning electron microscope (SEM) The results were compared with previous techniques advantages new investigated.