A5037362318- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Risk Factors
- Diabetes Management and Research
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Heart Failure Treatment and Management
- Bariatric Surgery and Outcomes
- Cardiovascular Disease and Adiposity
- Pancreatic function and diabetes
- Gestational Diabetes Research and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Health, Environment, Cognitive Aging
- Diabetes and associated disorders
- Obesity, Physical Activity, Diet
- Metabolism, Diabetes, and Cancer
- Bone and Joint Diseases
- Adolescent and Pediatric Healthcare
- RNA regulation and disease
- Potassium and Related Disorders
- Family Support in Illness
- Nutrition, Genetics, and Disease
- Cardiovascular Effects of Exercise
- Liver Disease and Transplantation
- Nutritional Studies and Diet
Johns Hopkins University
2023-2025
Johns Hopkins Medicine
2023-2025
Johns Hopkins Hospital
2025
Marmara University
2021
Marmara Üniversitesi Eğitim ve Araştırma Hastanesi
2020
Abstract Context Transitions in metabolic health status over time are strongly linked to risk for cardiovascular events, particularly among individuals with obesity. Adipokines proteins effects, but their role transitions is unknown. Objective To evaluate the associations of adiponectin and leptin time. Methods Among 8,423 who attended ARIC Visits 2 (1990-92) 4 (1996-98), we evaluated prospective Visit levels adipokines (per 1-SD higher) 6-year health. Metabolic was categorized as...
The prevalence of hypertension and uncontrolled may differ by age sex.
N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a cardiac biomarker used in the clinical management of heart failure. We sought to create updated reference intervals for NT-proBNP healthy US children, adolescents, and adults.
Background: Adipose tissue and its signaling molecules are central to cardiovascular-kidney-metabolic (CKM) syndrome development. High levels of pro-inflammatory adipokines low anti-inflammatory have been linked with worsening metabolic health increased cardiovascular disease (CVD) risk. However, there not yet investigations how relate changes in CKM over time. Methods: We examined 7695 White Black ARIC participants without baseline CVD adipokine measurements data required assess stage at...
Heterogeneity in type 2 diabetes presentation, progression and treatment has the potential for precision medicine interventions that can enhance care outcomes affected individuals. We undertook a systematic review to ascertain whether strategies subclassify are associated with improved clinical outcomes, show reproducibility have high quality evidence. reviewed publications deployed 'simple subclassification' using features, biomarkers, imaging or other routinely available parameters...
The biomarkers connecting obesity and cardiometabolic diseases are not fully understood. We aimed to (i) evaluate the associations between body mass index (BMI), waist circumference (WC), ∼5,000 plasma proteins (SomaScan v4), (ii) identify protein signatures of BMI WC, (iii) health including metabolically unhealthy type 2 diabetes incidence in Singapore Multi-Ethnic Cohort (MEC1). Among 410 BMI-associated 385 WC-associated proteins, we identified WC validated them an independent dataset...
Kidney transplantation (KT) recipients are at increased risk of low bone density (LBD) and fractures. In this retrospective study, we investigated mineral (BMD), vertebral fractures, calculated for major osteoporotic fractures (MOF), hip in the KT recipients.Patients who completed least one year after were included analysis. Demographic, clinical, laboratory data recorded. Measurements BMD performed by dual-energy X-ray absorptiometry. Vertebral assessed using semi-quantitative criteria with...
Objectives: Toronto hepatocellular carcinoma risk index is developed to stratify cirrhotic patients according 10-year risk. We aimed validate the performance of in a large Turkish cohort. Materials and methods: retrospectively reviewed database 1287 followed-up period (February 2008 January 2018). All were stratified into three groups based on score as follows: low-risk, < 120; intermediate risk, 120 240; high > 240. Area under curve optimal cutoff value obtained from receiver operator...
Background: Higher stages of Cardiovascular-Kidney-Metabolic (CKM) Syndrome are associated with greater cardiovascular disease (CVD) risk. However, the rates CKM stage progression over time and its impact on CVD outcomes currently unknown. Methods: We evaluated 8,367 ARIC Visit 4 (1996-98) participants without at 1 (1987-89), available data to define Visits 4. categorized based Stages 4, defined as: Stage 0, no risk factors; 1, excess/dysfunctional adiposity; 2, metabolic factors...
Background: Progression along Cardiovascular-Kidney-Metabolic (CKM) stages confers greater cardiovascular disease (CVD) risk. However, the factors associated with CKM stage progression over time are not yet defined. Methods: We evaluated ARIC Visit 4 (1996-98) participants without CVD at 1 (1987-89) and available data to define both Visits 4. were defined as: 0, no risk factors; 1, excess/dysfunctional adiposity; 2, metabolic (hypertriglyceridemia, hypertension, syndrome, or diabetes) and/or...