A5016678810- Cancer Immunotherapy and Biomarkers
- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Melanoma and MAPK Pathways
- Immunotherapy and Immune Responses
- Hedgehog Signaling Pathway Studies
- Tattoo and Body Piercing Complications
- Skin Diseases and Diabetes
- CAR-T cell therapy research
- Quinazolinone synthesis and applications
- Pharmacological Receptor Mechanisms and Effects
- Visual Culture and Art Theory
- Immune Cell Function and Interaction
- Body Image and Dysmorphia Studies
- Nail Diseases and Treatments
- Phenothiazines and Benzothiazines Synthesis and Activities
- Photodynamic Therapy Research Studies
- Economic and Financial Impacts of Cancer
- Teratomas and Epidermoid Cysts
- Reconstructive Facial Surgery Techniques
- Autoimmune and Inflammatory Disorders
- Cancer and Skin Lesions
- Adenosine and Purinergic Signaling
- Psoriasis: Treatment and Pathogenesis
- Hidradenitis Suppurativa and Treatments
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2020-2025
University of Naples Federico II
2014
Federico II University Hospital
2013
Abstract Background PD-1 blocking agents, such as nivolumab, have demonstrated clear anti-tumor effects and clinical benefits in a subset of patients with advanced malignancies. Nonetheless, more efforts are needed to identify reliable biomarkers for outcome, correctly select who will benefit from anti-PD-1 treatment. The aim this study was investigate the role peripheral CD8+T cells expressing CD73, involved generation immune suppressive molecule adenosine, predicting outcome after...
Abstract Background The clinical observation showed a potential additive effect of anti-PD-1 agents and cetirizine in patients with advanced melanoma. Methods Clinical outcomes concomitant cetirizine/anti-PD-1 treatment stage IIIb–IV melanoma were retrospectively collected, transcriptomic analysis was performed on blood samples obtained at baseline after 3 months treatment. Results Patients treated concomitantly an agent had significantly longer progression-free survival (PFS; mean PFS: 28...
Abstract Background Prognostic factors for initial response of advanced cutaneous squamous cell carcinoma to cemiplimab treatment are lacking. Il-6 has been found affect immune populations which impact tumor development. The aim was investigate the prognostic significance IL-6 serum levels before and during treatment. Methods Serum were correlated with clinical outcomes in a retrospective study. Results Overall, 39 patients enrolled. High (> 5.6 pg/ml) associated poorer survival (45.1% vs...
Background: Although complete excision of suspicious melanocytic lesions is mandatory, it carries the risk unnecessary scarring on one hand and inadequate treatment misdiagnosed other. Objectives: We evaluated sensitivity, specificity, predictive value reflectance confocal microscopy (RCM) in diagnosing pigmented with clinically ambiguous features―the so-called “gray zone” ―and compared its performance more established technique epiluminescence (ELM). Results: Between 2019 2020, a total 2282...
We present the case of a 64-year-old woman who presented to our clinic with recurrence superficial basal cell carcinoma left subocular region: patient had been treated surgically about 4 months previously. Dermoscopy examination showed focal ulceration, linear and arborizing (branch-like) telangiectasia. The refused another surgical or topical treatment, such as imiquimod, photodynamic therapy, for fear related side effects. After discussing patient, we decided start treatment tirbanibulin...
The real-life application of immune checkpoint inhibitors (ICIs) may yield different outcomes compared to the benefit presented in clinical trials. For this reason, there is a need define group patients that from treatment. We retrospectively investigated 578 metastatic melanoma treated with ICIs at Istituto Nazionale Tumori IRCCS Fondazione "G. Pascale" Napoli, Italy (INT-NA). To compare patients' variables (i.e., age, lactate dehydrogenase (LDH), neutrophil-lymphocyte ratio (NLR),...
Cosmetic breast procedures are widely performed by plastic surgeons all over the world with high satisfaction rate for patients. The most common complications described reduction mammaplasty and mastopexy wound dehiscence, asymmetry, partial or total loss of nipple-areolar complex (NAC). Pyoderma gangrenosum (PG) is a rare ulcerative dermatitis unclear origins first in 1930. In cases, it associated autoimmune systemic conditions such as Inflammatory Bowel Diseases several rheumatologic...
In December 2019, a novel coronavirus, “SARS-CoV-2”, was recognized as the cause of coronavirus disease 2019 (COVID-19). Several studies have explored changes and role inflammatory cells cytokines in immunopathogenesis disease, but until today, results been controversial. Based on these premises, we conducted retrospective assessment monocyte intracellular TNF-α expression (iTNF-α) frequencies lymphocyte sub-populations twenty-five patients with moderate/severe COVID-19. We found lymphopenia...
We read with great interest the article recently published by Abril-Pérez et al. in which they present a case of successful treatment refractory actinic keratoses and field cancerization on dorsum hands using 1% tirbanibulin ointment patient sun-exposed damaged skin. think presented authors is very useful we agree many aspects it wanted to report our own experience this drug for another dermatological cancer pathology, basal cell carcinoma.
Basal cell carcinoma (BCC) is the most common malignant tumor in white populations. Multiple studies demonstrated that aberrant activation of Hedgehog signaling a driver BCC development, and its blockade represents potential therapeutic target. In Italy, clinicians can prescribe inhibitors (HhIs) vismodegib sonidegib. To highlight treatment choice clinicians, we conducted an online survey between November 1 18, 2020, with 33 Italian from 27 reference hospitals, which each participant...
The development of new targeted therapies has considerably changed the therapeutic paradigm melanoma, significantly increasing overall survival (OS) and progression-free (PFS). However, skin-related adverse sequelae might occur impact on patients' quality life.In this article we will cover most important dermatological toxicities related to BRAF MEK-inhibitors, along with updated management strategies.BRAF inhibitors have represented a revolution in treatment melanoma. They improved outcome...
e22068 Background: Anti-PD-1 agents represent a standard treatment for melanoma patients. However, most patients fail to respond, showing in some cases very rapid disease progression. At moment, there are no effective biomarkers that can predict patient's clinical benefit. The aim of this study is retrospectively identify gene profiling could help select who likely respond anti-PD-1 therapy. Methods: We defined as fast responder (FR) or progressor (FP) got response progression after two...
e22008 Background: Nivolumab (nivo) 480 mg (Q4W) flat dose has already been assessed for safety compared to other drug regimens in clinical trials [1]. However, few data about melanoma patients treated real life are available. The aim of our study was evaluate and efficacy metastatic pts with different schedules nivo practice. Methods: We analyzed from n.124 who were Jun 2016 Oct 2019 at NCI Naples. 83/ 124 (67%) Q4W, 41/124 (33%) (n.26 [63%] 3 mg/kg, 15 [37%] 240 Q2W). All stage IV,...