Thiago Leite Fraga

ORCID: 0000-0003-2820-194X
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Research Areas
  • Antibiotic Resistance in Bacteria
  • Essential Oils and Antimicrobial Activity
  • Aquaculture disease management and microbiota
  • Antibiotics Pharmacokinetics and Efficacy
  • Research on Leishmaniasis Studies
  • Ethnobotanical and Medicinal Plants Studies
  • Aquaculture Nutrition and Growth
  • Piperaceae Chemical and Biological Studies
  • Fish biology, ecology, and behavior
  • Phytochemistry and Biological Activities
  • Milk Quality and Mastitis in Dairy Cows
  • Healthcare and Environmental Waste Management
  • Environmental Sustainability and Education
  • Morinda citrifolia extract uses
  • Pharmaceutical and Antibiotic Environmental Impacts
  • Phytochemistry Medicinal Plant Applications
  • Vector-Borne Animal Diseases
  • Food Waste Reduction and Sustainability
  • Bioactive Compounds and Antitumor Agents
  • Food Safety and Hygiene
  • Animal Virus Infections Studies
  • Phytochemicals and Medicinal Plants
  • Agricultural and Food Sciences
  • Natural product bioactivities and synthesis
  • Leptospirosis research and findings

Centro Universitário da Grande Dourados
2015-2024

Universidade Unigranrio
2016-2022

Universidade Federal da Grande Dourados
2022

Universidade Federal de Mato Grosso do Sul
2010-2016

Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul
2016

Objective: The antimicrobial activities of the synergistic combination carvacrol and polymyxin B against polymyxin-resistant Klebsiella pneumoniae were evaluated. Methods: methods employed checkerboard assays to investigate synergism, biofilm inhibition assessment membrane integrity assay. In addition, study included in vivo evaluation using a mouse infection model. Results: method evaluated 48 combinations, with 23 indicating action. Among these, 10 mg/kg plus 2 exhibited activity model...

10.2217/fmb-2023-0070 article EN Future Microbiology 2024-02-01

Dissemination of carbapenem-resistant Klebsiella pneumoniae poses a threat to the successful treatment bacterial diseases and increases need for new antibacterial agents development. The objective this study was determine antimicrobial activity carvacrol against multidrug-resistant K . Carbapenemase production detected by MALDI-TOF. PCR sequencing showed that bla KPC-2, OXA-48 , NDM-1 CTX-M-8 genes were present in strains. polymyxin-resistant strain exhibited alterations mgr B gene....

10.1371/journal.pone.0246003 article EN cc-by PLoS ONE 2021-02-22

The rearing environment of pigs can cause a high level stress due to the lack stimuli and impossibility carrying out natural behaviors. Music therapy is way enrich promote relief. Few studies in swine using environmental enrichers focus on functional benefits, such as resilience, improved biological functions, or mental status. effect enrichment neurobiological processes particularly poorly understood farm animals. Thus, our study sought elucidate influence music piglets exposed intrauterine...

10.3390/ani12172211 article EN cc-by Animals 2022-08-28

The diagnosis of visceral leishmaniasis (VL) generally requires the use invasive tests for collection infected tissue (aspirates bone marrow, spleen, liver or lymph nodes). This difficulty has led to search safer and less painful techniques confirm occurrence disease in children. Polymerase chain reaction (PCR) is a method that advantageous it allows peripheral blood samples diagnosis. paper reports utilisation PCR on diagnose VL 45 children Mato Grosso do Sul, Brazil. technique compared...

10.1590/s0074-02762010000300011 article EN Memórias do Instituto Oswaldo Cruz 2010-05-01

Abstract Objectives To evaluate the synergistic effect of a ceftibuten and polymyxin B combination to determine its capacity overcome resistance in polymyxin/carbapenem-resistant (PC-R) Klebsiella pneumoniae. Methods investigate combination’s antibacterial efficacy, antimicrobial susceptibility tests using broth microdilution methods, chequerboard assays time–kill testing were performed. Antibiofilm activity was also assessed. The treatment’s on bacterial cell membrane examined by...

10.1093/jac/dkae382 article EN Journal of Antimicrobial Chemotherapy 2024-10-14

ABSTRACT A retrospective review of hematological reports nine dogs detected with Hepatozoon canis infection by microscopic examination blood smears in a laboratory the municipality Dourados, Mato Grosso do Sul, Brazil was conducted. This study aimed to evaluate profile these infected dogs, addition occurrence coinfections other agents that infect cells, since studies concerning canine hepatozoonosis are scarce and there some divergences regarding H. still require resolution. The cases were...

10.1590/1678-4162-8350 article EN cc-by Arquivo Brasileiro de Medicina Veterinária e Zootecnia 2016-10-01

The aim of the present study was to assess presence antissaliva antibodies Lutzomyia longipalpis in human hosts living area visceral leishmaniasis, located Center-West region Brazil. L. exhibited a strong correlation with protection and development against Leishmania sp. Of 492 children studied, elevated were detected 38.4% participants. There higher percentage positivity (64.7%) among who anti-Leishmania those positive delayed hypersensitivity test (34.8%).

10.1097/inf.0000000000001172 article EN The Pediatric Infectious Disease Journal 2016-04-19

O ovo é um alimento com alto valor nutricional, contendo muitas proteínas, vitaminas e minerais, baixo custo o que estimula consumo. Por ser produto perecível necessário armazená-lo corretamente para este possa estar viável consumo por longo período. objetivo desta pesquisa foi avaliar a qualidade interna de ovos brancos vermelhos armazenados em temperatura ambiente sob refrigeração durante 25 dias armazenamento. Os apresentam perda viabilidade aos 15 estocagem, já os geladeira estocagem. A...

10.3738/1982.2278.1576 article PT Nucleus Animalium 2016-11-30

Pharmacognosy Research,2022,14,2,127-134.DOI:10.5530/pres.14.2.18Published:April 2022Type:Original ArticleAuthors:Maicon Matos Leitão, Joyce Alencar Santos Radai, Luis Fernando Benitez Macorini, Thiago Leite Fraga, Silvia Cristina Heredia-Viira, Claudia Andrea Lima Cardoso, Arielle Arena, and Candida Aparecida Kassuya Author(s) affiliations:Maicon Leitão1,2,*, Radai1, Macorini1, Fraga1, Heredia-Vieira3, Cardoso4, Arena5, Kassuya1 1School of Health Sciences, Federal University Grande...

10.5530/pres.14.2.18 article EN cc-by Pharmacognosy Research 2022-04-24

Abstract Objectives: This study investigated the antimycobacterial, anti-inflammatory and antihyperalgesic effects of hydroalcoholic extract from leaves S. marginata (EESM) in vitro vivo models. Methods Results: EESM (0.98–1000 µg/ml) was evaluated against Mycobacterium tuberculosis, M. bovis, Klebsiella pneumoniae , Pseudomonas aeruginosa Staphylococcus epidermidis. The oral administration (p.o.) (30, 100 300 mg/kg) dexamethasone subcutaneous injection (s.c.) (1 were tested...

10.21203/rs.3.rs-283967/v2 preprint EN cc-by Research Square (Research Square) 2022-01-17

O objetivo deste estudo foi isolar e caracterizar Aeromonas hydrophila, causadora de mortalidade em peixes descrever as alterações histopatológicas provocadas nas brânquias machos beta Bettas plendens. Foram utilizados dez que apresentavam característica alteração comportamento como anorexia, letalidade apatia. Amostras água, muco foram inoculadas meio cultura Agar sangue a 25ºC por 48 horas. Foi caracterizado A. hidrófila principal causa do surto mortalidade. observadas desde fusão lamelar...

10.25110/arqvet.v17i1.2014.4917 article PT Arquivos de Ciências Veterinárias e Zoologia da UNIPAR 2015-03-18

The objective of this study was to describe the behavior C-reactive protein (CRP), compared results California Mastitis Test (CMT) in dairy cows. Thirty - eight cows were used detect subclinical mastitis. Among these animals, 21 (75%) positive CMT test and 10 (35.7%) PCR positive. When analyzing by McNemar it possible conclude that diagnostic tests have no statistical relation. It can be concluded as an aid interpretation for mastitis when associated with CMT.

10.22256/pubvet.v11n9.860-863 article EN cc-by PubVet 2017-08-04

A criação de ovinos possui grande importância sócio-econômica e cultural para o estado Mato Grosso do Sul vem sendo amplamente explorada, por meio da raças adaptadas ao clima região mercado consumidor, a produção impulsionada principalmente necessidade diversificação das atividades produtivas no rural. Apesar incremento produtivo setor, ainda hoje existem entraves à otimização desempenho global dos rebanhos ovinos, dentre eles está helmintose resistência anti-parasitária alopáticos....

10.35172/rvz.2022.v29.675 article PT Veterinária e Zootecnia 2022-07-19
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