A5102752273- Asymmetric Hydrogenation and Catalysis
- Synthesis and Characterization of Heterocyclic Compounds
- Asymmetric Synthesis and Catalysis
- Sulfur-Based Synthesis Techniques
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Reactions
- Chemical Synthesis and Analysis
- DNA and Nucleic Acid Chemistry
- Synthesis and biological activity
- Boron Compounds in Chemistry
- Analytical Chemistry and Chromatography
- Electrostatics and Colloid Interactions
- Cancer Treatment and Pharmacology
- Chemical Reactions and Isotopes
- Organoboron and organosilicon chemistry
- Carbohydrate Chemistry and Synthesis
- Quinazolinone synthesis and applications
- Cardiac electrophysiology and arrhythmias
- Nanopore and Nanochannel Transport Studies
- Multicomponent Synthesis of Heterocycles
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Intracranial Aneurysms: Treatment and Complications
- Hedgehog Signaling Pathway Studies
- Gene Regulatory Network Analysis
Toyota Central Research and Development Laboratories (Japan)
2022
Kissei Pharmaceutical (Japan)
1999-2008
Central Research Laboratories (United Kingdom)
1999-2003
Oita University
2002-2003
Hiroshima University
2001
Tokyo University of Science
1991-1999
We synthesized a series of novel 2-anilinopyrazolo[1,5-a]pyrimidine derivatives and evaluated their ability to inhibit c-Src kinase; 7-(2-amino-2-methylpropylamino)-5-cyclopropyl-2-(3,5-dimethoxyphenylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide 7o 7-(2-amino-2-methylpropylamino)-2-(3,5-dimethoxyphenylamino)-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide 7f showed potent inhibitory activity. Compound inhibited selectively exhibited satisfactory central nervous system (CNS) penetration....
A new method for the total asymmetric synthesis of antitumor agent Taxol is described. Baccatin III, a complex carbon framework, synthesized by way B to BC ABC ring construction. Further, forming from baccatin III and β-amino acid also demonstrated.
Abstract The asymmetric borane reduction of prochiral ketones with catalysts prepared in situ from aluminum triethoxide and chiral amino alcohols was examined, the corresponding were obtained high optical purity.
Structural data of protein–DNA complex show redundancy and flexibility in base–amino acid interactions. To understand the origin specificity recognition, we calculated interaction free energy, enthalpy, entropy, minimum energy maps for AT-Asn, GC-Asn, AT-Ser, GC-Ser by means a set ab initio force field with extensive conformational sampling. We found that most preferable interactions these pairs are stabilized hydrogen bonding, mainly enthalpy driven. However, minima not necessarily same as...
Hair graying in mice is caused by various injuries such as X-ray radiation and repeated plucking that ultimately damage melanocytes their stem cells (melanocyte cells). In X-ray‒induced hair graying, first manifest a loss-of-niche function of follicular keratinocyte to maintain melanocyte cells. Thus, we hypothesized could be practical target prevent graying. this study, investigated the vivo effect flavonoid hydroxygenkwanin, which has been shown exert best protection on human epidermal...
We describe the practical synthetic route for (2S)-7-methoxy-1,2,3,4-tetrahydro-2-naphthylamine 1(2S)-2-amino-7-methoxytetraline; (S)-AMT]. (2R)-2-(3-Methoxybenzyl)succinic acid [(R)-1] was obtained by optical resolution of 2-(3-methoxybenzyl)succinic (1) as salt (1R,2S)-2-(benzylamino)cyclohexylmethanol (7), and (R)-1 converted to optically active (2S)-7-methoxy-1,2,3,4-tetrahydro-2-naphthoic [(S)-2] intramolecular Friedel-Crafts reaction followed catalytic hydrogenation. (S)-AMT from (S)-2...
Chiral bis(α, α-diphenyl-2-pyrrolidinemethanol) carbonate (DPP2·H2CO3) is a useful asymmetric auxiliary for the borane reduction of prochiral ketones. DPP2·H2CO3 recoverable from reaction and directly reusable reaction. The intermediate KUR-1246, which we are developing as new uterine relaxant, was synthesized using methodology.
The synthetic route for a uterine relaxant, bis(2-{[(2S)-2-({(2R)-2-hydroxy-2-[4-hydroxy-3-(2-hydroxyethyl)-phenyl]ethyl}amino)-1, 2, 3, 4-tetrahydronaphthalen-7-yl]oxy}-N, N-dimethylacetamide) sulfate (KUR-1246), was established by the coupling of optically active components, bromohydrin 14 and amine 24. We now describe practical synthesis these two components. Bromohydrin obtained asymmetric borane reduction prochiral phenacyl bromide 13 using catalyst prepared from aluminum triethoxide...
Abstract Optically active 1α-allyl-1β,11β-benzylidenedioxy-2α,10β-bis(benzyloxy)-7β,9β-isopropylidenedioxy-8α,12,12-trimethyl-4-methylenebicyclo[6.4.0]dodecane (2)1 which corresponds to BC ring system of 8-epitaxoids was prepared in high yield form ketoaldehyde 8 via intramolecular aldol cyclization and succesive stereoselective methylation reactions. The synthesized from 8-membered compound 3 by Michael addition using higher-order cuprate.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access Abstract, please click on HTML or PDF.
We proposed a new theoretical circuit which is based on the multiple phase complex biochemical reaction under time minimum optimal control principle. The characterized by an allosteric enzyme, conformation of changes depending number bound substrates. As enzyme substrates increases, structure successively. Then, affinities residual subunits are potentiated. present application and modeling will be applicable for creating electronic its evaluation.
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Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
A method was introduced for computing the three dimensional distributions of electro static potentials and forces in a DNA molecule with helically distributed electri cal charges. cylindrical model composed an inner region where discrete char ge does not exist, middle there is interaction between charges ex ternal ions interact. The potential each described by Laplace Poisson equations. Green function applied helical charge distrib ution within one turn finite cylinder. calculated depended...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”