A5082802722- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiovascular Issues in Pregnancy
- Congenital Heart Disease Studies
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Hemodynamic Monitoring and Therapy
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
- Vascular Anomalies and Treatments
- Lipoproteins and Cardiovascular Health
- Blood Pressure and Hypertension Studies
- Pericarditis and Cardiac Tamponade
- Myasthenia Gravis and Thymoma
- Chemical Thermodynamics and Molecular Structure
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Healthcare Systems and Public Health
- Healthcare cost, quality, practices
- Infective Endocarditis Diagnosis and Management
- Vasculitis and related conditions
- Cardiac, Anesthesia and Surgical Outcomes
University of British Columbia
2014-2024
Vancouver General Hospital
2017-2021
Toronto Public Health
2018
Stanford University
2013-2015
University of Copenhagen
2013
Stanford Medicine
2013
Keio University
2013
Background The evolution in pulmonary arterial hypertension (PAH) management has been summarised three iterations of the European Society Cardiology/European Respiratory (ESC/ERS) guidelines. No study assessed whether changes management, as reflected changing guidelines, translated to improved long-term survival PAH. Methods We performed a mixed retrospective/prospective analysis treatment-naïve, incident PAH patients (n=392) diagnosed at major centres Canada from 2009 2021. Patients were...
The landscape of pulmonary hypertension (PH) has changed significantly since the last Canadian Cardiovascular Society/Canadian Thoracic Society position statement in 2005. Since then, advances our understanding pathophysiology PH and improvements diagnostic therapeutic options have transformed care patients with PH. Globally, an estimated prevalence 1%, increasing to 10% those aged 65 years older, most commonly due left heart or lung disease. Although arterial (PAH) is less common, morbidity...
To evaluate the association between markers of precapillary pulmonary hypertension (PH) and survival in transcatheter aortic valve replacement (TAVR).The importance PH has been sparsely investigated patients undergoing TAVR. It may prove an important risk factor for poor outcomes.We identified at our institution TAVR with a baseline right heart catheterization (RHC) demonstrating PH. We evaluated including diastolic gradient (DPG), transpulmonary (TPG), vascular resistance (PVR). A...
Although left atrial function has been extensively studied in patients with heart failure, the determinants and clinical correlates of impaired right (RA) have poorly studied. We investigated measures RA pulmonary arterial hypertension (PAH). identified all treatment-naive World Health Organization category 1 PAH seen at our center during 2000-2011 who had catheterization 6-minute walk test (6MWT) within month initial echocardiographic examination. Atrial size was measured using monoplane...
The determination of LV filling pressure is integral to the diagnosis pulmonary arterial hypertension (PAH). American Society Echocardiography (ASE) has devised algorithms for their estimation. We aimed test these in a population referred suspected PAH. In our retrospective study, we evaluated accuracy ASE Algorithms compared right heart catheterization done within three months, patients seen during 2006-2014. All echocardiograms were classified as showing normal, elevated or indeterminate...
Pulmonary artery (PA) vasculitis occurs in association with primary vasculitides-in particular, giant cell arteritis, Takayasu's or Behçet's disease-or secondary as a result of infections malignancy. However, PA isolation and concomitant aneurysmal dilation is an unusual finding. We present rare case aneurysm to isolated asymptomatic patient no features systemic vasculitis. This highlights one the first cases managed surgical resection alone.
Fluid challenge during right heart catheterization has been used for unmasking pulmonary hypertension (PH) related to left‐sided disease. We evaluated the clinical and hemodynamic factors affecting response fluid investigated role of in classification management PH patients. reviewed charts 67 patients who underwent with a baseline arterial wedge pressure (PAWP) ≤ 18 mmHg. A positive (PFC) was defined as an increase PAWP > mmHg after 500 mL saline infusion. Clinical characteristics...
Chronic constrictive pericarditis (CP) is a relatively rare condition in which the pericardium becomes fibrotic and noncompliant, eventually resulting heart failure due to impaired ventricular filling. The only curative treatment pericardiectomy. Classically, CP does not usually cause severe pulmonary hypertension. When attempting differentiate from restrictive cardiomyopathy, presence of severely elevated arterial pressure used as diagnostic criterion ruling against CP. We present case...
After myocardial infarction, guidelines recommend higher-potency P2Y12 receptor inhibitors, namely ticagrelor and prasugrel, over clopidogrel.We aimed to determine the contemporary use of antiplatelet therapy in Canadian patients with non-ST-elevation infarction (NSTEMI).A total 684 moderate-to-high risk NSTEMI were enrolled prospective ACS Reflective II registry at 12 hospitals three clinics five provinces between July 2016 May 2018. Multivariable logistic regression modeling was performed...