A5102882117- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Pluripotent Stem Cells Research
- Hydrogen's biological and therapeutic effects
- Cancer-related molecular mechanisms research
- Hippo pathway signaling and YAP/TAZ
- Mesenchymal stem cell research
- Ferroptosis and cancer prognosis
- Developmental Biology and Gene Regulation
- Tryptophan and brain disorders
- Treatment of Major Depression
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ion Transport and Channel Regulation
- Nitric Oxide and Endothelin Effects
- Telomeres, Telomerase, and Senescence
- Nutrition, Genetics, and Disease
- Renal function and acid-base balance
- Tea Polyphenols and Effects
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immune Response and Inflammation
- Inflammatory mediators and NSAID effects
- Hemodynamic Monitoring and Therapy
- Cystic Fibrosis Research Advances
- Inflammation biomarkers and pathways
- Trauma Management and Diagnosis
Army Medical University
2022
Harbin Medical University
2021
Second Affiliated Hospital of Harbin Medical University
2021
Zhongda Hospital Southeast University
2018-2020
Wenzhou Medical University
2013-2018
Jinzhou Kangning Hospital
2018
Guizhou Provincial People's Hospital
2018
Mesenchymal stem cells (MSCs) derived from bone marrow have potent stabilizing effects for the treatment of acute respiratory distress syndrome (ARDS). However, low efficiency and survival in MSC homing to injured lung tissue remains be solved. Therefore, aim this study was assess whether large intergenic noncoding RNA (LincRNA)-p21 promote migration capacity through hypoxic preconditioning vitro.MSCs were cultured divided into normoxia culture group (20% O2) hypoxia (1% O2). To determine...
Edema fluid resorption is critical for gas exchange, and both alveolar epithelial sodium channel (ENaC) Na,K-ATPase are accredited with key roles in the resolution of pulmonary edema. Alveolar clearance (AFC) was measured situ ventilated lungs by instilling isosmolar 5% BSA solution Evans Blue-labeled albumin tracer (5 ml/kg) measuring change concentration over time. Treatment lipoxin A4 receptor agonist (5(S), 6(R)-7-trihydroxymethyl 17 heptanoate) significantly stimulated AFC oleic acid...
L-theanine, originally found in green tea, elicits various physiological effects, such as promoting relaxation, improving concentration and learning ability, providing antianxiety-like antidepressant-like properties. This study aims to investigate the effects of L-theanine (2 mg/kg) on monoamine levels an animal model depression. The effect l-theanine symptoms depression was examined through open-field test, sucrose preference forced swim test. neurotransmitters that involve serotonin...
The lipoxins are the first proresolution mediators to be recognized and described as endogenous “braking signals” for inflammation. We evaluated anti-inflammatory bioactions of lipoxin A 4 in our lipopolysaccharide (LPS-)induced lung injury model. demonstrated that significantly improved histology rat lungs inhibited IL-6 TNF- α LPS-induced injury. In addition, increased alveolar fluid clearance (AFC) effect on AFC was abolished by<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Fibroblasts, far frombeing merely bystander cells, are known to play a specific role in inflammation resolution after an acute injury. As the endogenous “braking signal,” resolvins possess potent anti-inflammatory and proresolution actions. We demonstrated that expression of COX-2 protein was significantly peaked initially at 6 hours but then also 48 LPS stimulation lung fibroblasts. PGE 2 levels hours, PGD were increased hours. However, no significant change COX-1 observed treatment with...
Objective: This study aimed to discuss changes in the T-lymphocyte immune functions of patients with cervical cancer after surgery and their clinical significance. Methods: A total 80 who had undergone surgical treatment our hospital from January 2014 July 2017 were selected as observation group. Additionally, 50 healthy women volunteers same time period considered control T-lymphocyte-secreted cytokines function indices examined before all respondents. Detection results two groups compared....
Objective To evaluate the effect of operative treatment non-flail chest rib fractures. Methods A retrospective analysis 109 patients who underwent fractures between May 2015 and June 2016 was conducted. We compared patients’ pain index pulmonary function parameters (vital capacity, VC; forced vital capacity in first second, FEV1; peak expiratory flow, PEF) at different stages: hospital admission (IN), on day before surgery (PRE), postoperative days one (D1), two (D2), seven...
Abstract Background: T helper 17 cells (Th17)/ regulatory (Treg), as subtypes of CD4+T cells, played an important role in the inflammatory response acute respiratory distress syndrome (ARDS). However, there is still a lack effective methods to regulate differentiation balance Th17/Treg. It was proved that mesenchymal stem (MSCs) could but mechanism unclear. TGFβ1, one paracrine cytokines MSCs, also Th17/Treg possess low expression MSCs. Therefore, mouse MSCs (mMSCs)overexpressing TGFβ1...
Transcriptional enhanced associate domain (TEAD) transcription factors play important roles in embryonic stem cell (ESC) renewal and differentiation. Four TEAD (Tead1, Tead2, Tead3 Tead4) their various splice variants have been discovered mice, but the expression pattern of them during pluripotency state transition is unclear. Here, we investigated TEADs mouse ESCs at different pluripotent/differentiating states adult tissues. Our results preliminarily revealed diversity heterogeneity...
Abstract Background: Rapid advances in genetic and genomic technologies have begun to reshape our understanding of idiopathic pulmonary fibrosis (IPF). Ferroptosis, an iron-dependent form regulated cell death, play important role the development IPF. Therefore, study aimed explore ferroptosis-related genes (FRGs) their correlation with lung dysfunction quality life patients Methods: Datasets were acquired by researching Gene Expression Omnibus. FRGs GeneCard database PubMed....