A5101997306- Sepsis Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Air Quality and Health Impacts
- Respiratory Support and Mechanisms
- Liver Disease Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Climate Change and Health Impacts
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Hemodynamic Monitoring and Therapy
- Hepatitis B Virus Studies
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Mesenchymal stem cell research
- Pneumonia and Respiratory Infections
- Immune cells in cancer
- Infections and bacterial resistance
- PARP inhibition in cancer therapy
- Global Health Care Issues
- Hepatitis C virus research
- Neurobiology and Insect Physiology Research
- Appendicitis Diagnosis and Management
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
Hainan University
2025
Shenzhen Institutes of Advanced Technology
2024
Chinese Academy of Sciences
2024
Anhui Medical University
2014-2024
Wuxi People's Hospital
2013-2024
Second Hospital of Anhui Medical University
2014-2024
Sir Run Run Shaw Hospital
2024
Zhejiang University
2008-2024
Xiamen University
2022-2024
Jiangnan University
2017-2023
Neural activity actively regulates muscle gene expression. This regulation is crucial for specifying functionality and synaptic protein How neural relayed into nuclei connected to the transcriptional machinery, however, not known. Here we identify histone deacetylase HDAC4 as critical linker connecting transcription. We found that normally concentrated at neuromuscular junction (NMJ), where nerve innervates muscle. Remarkably, reduced input by surgical denervation or diseases dissociates...
Abstract Background Mesenchymal stem cells (MSCs) have been shown to alleviate acute lung injury (ALI) via paracrine hepatocyte growth factor (HGF) and induce the differentiation of dendritic (DCs) into tolerogenic (DCregs) participate in immune response. However, whether MSCs production DCregs by secreting HGF early ALI remains unclear. We observed that protective effect mouse bone marrow-derived against lipopolysaccharide (LPS)-induced was achieved inducing mature DCs (mDCs) differentiate...
Mesenchymal stem cells (MSCs) derived from bone marrow have potent stabilizing effects for the treatment of acute respiratory distress syndrome (ARDS). However, low efficiency and survival in MSC homing to injured lung tissue remains be solved. Therefore, aim this study was assess whether large intergenic noncoding RNA (LincRNA)-p21 promote migration capacity through hypoxic preconditioning vitro.MSCs were cultured divided into normoxia culture group (20% O2) hypoxia (1% O2). To determine...
Exposure to ozone has been associated with metabolic disorders in humans, but the underlying mechanism remains unclear. In this study, role of gut-liver axis and potential behind disorder were investigated by histological examination, microbiome metabolome approaches mice during subacute (4-week) subchronic (12-week) exposure 0.5 ppm 2.5 ozone. Ozone resulted slowed weight gain reduced hepatic lipid contents a dose-dependent manner. After ozone, number goblet cells decreased, while tuft...
The ubiquitin–proteasome pathway has been implicated in synaptic development and plasticity. However, mechanisms by which ubiquitination contributes to precise dynamic control of plasticity are poorly understood. We have identified a PDZ domain containing RING finger 3 (PDZRN3) as synapse-associated E3 ubiquitin ligase demonstrated that it regulates the surface expression muscle-specific receptor tyrosine kinase (MuSK), key organizer postsynaptic at mammalian neuromuscular junction. PDZRN3...
BackgroundThe p53 tumour suppressor protein is a transcription factor that prevents oncogenic progression by activating the expression of apoptosis and cell-cycle arrest genes in stressed cells. The stability tightly regulated ubiquitin-dependent degradation, driven mainly its negative regulators ubiquitin ligase MDM2. Principal FindingsIn this study, we have identified OTUD5 as DUB interacts with deubiquitinates p53. forms direct complex controls level ubiquitination. function required to...
Abstract Background Mesenchymal stem cells (MSCs) have been shown to alleviate acute lung injury (ALI) and induce the production of regulatory dendritic (DCregs), but potential link between these two cell types remains unclear. The goal this study was investigate effect mechanism MSC-induced in ALI mice. Material/methods In vivo experiments, C57BL/6 wild-type male mice were sacrificed at different times after intratracheal injection LPS observe changes DC maturation pathological damage....
Certain sub-groups, including men and obese individuals, are more susceptible to ozone (O3) exposure, but the underlying molecular mechanisms remain unclear. In this study, male mice were divided into two dietary groups: one fed a high-fat diet (HFD), mimicking obesity conditions, other normal (ND), then exposed 0.5 ppm 2 O3 for 4 hours per day over days. The HFD exhibited significantly higher body weight serum lipid biochemical indicators compared ND mice. Obese also severe pulmonary...
Aeromonas veronii is a vital zoonotic pathogen known for its extensive drug resistance and ability to form biofilms, which contribute antibiotic resistance. In this study, the phage vB_C4, specifically targeting A. veronii, was isolated subjected bioinformatic analysis bacteriostatic activity assays. The combination of vB_C4 with antibiotics such as cephalothin cefoxitin, target bacterial cell wall, resulted in significantly enhanced effect compared either or alone. Furthermore, dosage...
To investigate the current status of long-term quality life in patients with severe acute pancreatitis (SAP) who have been cured and discharged, to analyze influencing factors affecting SAP after discharge. A retrospective collection was conducted. Patients were received standardized treatment before being discharged from hospital admitted first department critical care medcine Second Affiliated Hospital Anhui Medical University January 2017 December 2023 enrolled. According 36-item short...
Biological nitrogen fixation (BNF) facilitated by nitrogen-fixing bacteria (NFBac) offers a sustainable alternative to conventional fertilizers. However, acidic soil conditions, characterized reduced pH levels, nutrient deficiencies, and disrupted microbiomes, present significant challenge the effectiveness of NFBac. This study proposes nanoengineering approach bolster resilience functionality NFBac in soils. Azotobacter Pseudomonas stutzeri A1501 cells are sequentially coated with...
The aim of the present study was to determine role nucleolar and spindle‑associated protein 1 (NuSAP1) in human liver cancer. NuSAP1 expression determined by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR), western blotting immunohistochemistry hepatocellular carcinoma (HCC) adjacent tissues. gene detected RT‑qPCR cancer cell lines. Expression information for using UALCAN Oncomine databases. Kaplan‑Meier plotter Cancer Genome Atlas databases were used obtain overall...
Esophageal cancer (EC) is the eighth most common highly aggressive worldwide. The purpose of this study was to investigate effect DNA methyltransferase inhibitor RG108 on radiosensitivity EC cells. MTT and clonogenic assays were performed assess proliferation Eca‑109 TE‑1 human cell cycle progression alterations in apoptosis analyzed by flow cytometry. For vivo analysis, cells inoculated into nude mice establish tumors. Tissues from xenografts obtained detect changes microvessels tumor...
Radiotherapy is a main modality of esophageal squamous cell carcinoma (ESCC) treatment, while radioresistance largely limits the effect this therapy. Evidence exists reporting that SOX17 may sensitize ESCC cells to irradiation, but downstream mechanism remains poorly understood. Therefore, we attempt explore molecular basis on in ESCC. The expression was measured tissues and cells, followed by evaluation its relationship with patient survival. fractionated irradiation-induced...
Exposure to fine particulate matter (PM2.5) during pregnancy has been inversely associated with neonatal neurological development. However, the associations of exposure specific PM2.5 constituents development remain unclear. We investigated these and examined mediating role meconium metabolites in a Chinese birth cohort consisting 294 mother–infant pairs. Our results revealed that its (i.e., organic matter, black carbon, sulfate, nitrate, ammonium) second trimester, but not first or third...
Abstract Background Hypertension is highly prevalent and associated with the elevated risks of cardiovascular diseases, dementia, physical disabilities among adults. Although correlation between bilirubin hypertension has been reported, observation in quinquagenarian population scarce. We aimed to examine bilirubin-hypertension association Guankou Ageing Cohort Study. Methods Participants ≥ 55 years were recruited their questionnaires examination data collected. Kaplan–Meier survival...
To study the antifungal activities of a prepared food-grade dilution-stable microemulsion against Aspergillus niger.Results from activity on solid medium by agar dilution method showed that caused complete growth inhibition at 2000 ppm, and 1000 55% after 4 days incubation delay conidiation 1 day compared with controls. Results in liquid broth A. niger was completely inhibited when containing 10(6) spores per ml treated 500 ppm microemulsion, which determined minimum fungicidal...