Abstract Biofilm microenvironment (BME)‐activated antimicrobial agents display great potential for improved biofilm‐related infection therapy because of their superior specificities and sensitivities, effective eliminations, minimal side effects. Herein, BME‐activated Fe‐doped polydiaminopyridine nanofusiform‐mediated single‐atom nanozyme (FePN SAzyme) is presented photothermal/chemodynamic synergetic bacteria‐infected wound therapy. The photothermal (PTT) function SAzyme can be specifically...

Nanozyme-based tumor collaborative catalytic therapy has attracted a great deal of attention in recent years.However, their cooperative outcome remains challenge due to the unique characteristics microenvironment (TME), such as insufficient endogenous hydrogen peroxide (H2O2) level, hypoxia, and overexpressed intracellular glutathione (GSH).Methods: Herein, TME-activated atomic-level engineered PtN4C single-atom nanozyme (PtN4C-SAzyme) is fabricated induce "butterfly effect" reactive oxygen...

ABSTRACT Objective This study aimed to examine the impact of laser‐assisted hatching (LAH) on physical, metabolic, cognitive and behavioural profiles singletons conceived through frozen–thawed embryo transfer (FET) at preschool age. Design A matched cohort study. Setting The reproductive centre Women's Hospital, Zhejiang University School Medicine. Population Singletons born couples with infertility who underwent FET cycles or without LAH treatment from 2016 2019 were followed up till age...

BACKGROUND To assess the non-adherence rate among pulmonary tuberculosis (TB) patients in Anhui Province, eastern China and to explore influential factors, so as identify targets for intervention. MATERIAL AND METHODS A total of 339 TB were recruited from dispensaries 8 counties using a stratified sampling method. All study subjects surveyed structured questionnaire. Differences between groups involving categorical data analyzed chi-square test. RESULTS Overall, patients, 33.63% missed...

This study aimed to evaluate the influence of origin information on Pinot Noir wine labels using eye-tracking and its associations with purchase intent, hedonic subconscious emotional responses. Two studies were carried out untrained university staff students aged 20-60 years old. Study 1 was conducted assess consumers' (n = 55; 55% males, 45% females) self-reported responses towards four design (with without New Zealand name/script or logo) video analysis emotions participants. In 2,...

Endometriosis is associated with systemic metabolic indicators, including body mass index (BMI), glucose metabolism and lipid metabolism, while the association between indexes occurrence assisted reproductive technology (ART) outcome of endometriosis unclear. We aimed to evaluate characteristics patients infertility their effects on pregnancy after ART treatment. A retrospective cohort study involve 412 1551 controls was conducted. Primary indexes, secondary measures consisted influence...

The staging system for patients with anaplastic thyroid cancer (ATC) was updated in the 8th edition of American Joint Committee on Cancer Staging Manual. A cut-off age 55 years stipulated as a prognostic factor differentiated cancer; however, not considered ATC patients. To this end, study investigated relationship between at diagnosis and prognosis patients.The clinical information acquired from Surveillance, Epidemiology, End Results Program public database. Youden's index X-tile analyses...

Radiotherapy is a main modality of esophageal squamous cell carcinoma (ESCC) treatment, while radioresistance largely limits the effect this therapy. Evidence exists reporting that SOX17 may sensitize ESCC cells to irradiation, but downstream mechanism remains poorly understood. Therefore, we attempt explore molecular basis on in ESCC. The expression was measured tissues and cells, followed by evaluation its relationship with patient survival. fractionated irradiation-induced...

Metal-based nanomaterials with shifting or mixed redox states have been widely applied for combating against bacteria-infected diseases by virtue of their peroxidase (POD)-like catalytic activity. Herein, a polyoxometalate-based heterojunction (GdP5W30@WS2) (W6+/W5+) is devised to achieve boosted reactive oxygen species (ROS) generation near-infrared (NIR) laser-facilitated W6+/W5+ cycling accelerated wound healing. On the one hand, under exposure NIR laser, WS2 as electron donor could be...

Background Apigenin (APG), a natural flavonoid, can affect the development of variety tumors, but its role in ovarian cancer remains unclear. There has been an increasing amount evidence supporting vital played by mast cells and bioactive mediators they release, as components tumor microenvironment, progression (OC); however, mechanism warrants further exploration. Methods Results In this study, combination transcriptomics analysis application TCGA database was performed, we found that...

Low-dose ketamine has been proved to reduce opioid consumption, prevent depressant action and improve postoperative analgesia. Women undergoing mastectomy experience may not only have persistent pain syndromes but also emotional problems. However, the effect of intraoperative infusion low-dose on quality recovery among these patients yet fully studied.In this prospective, randomised, single-centre trial, 100 planned for modified radical were randomly assigned one two groups: control group...

Abstract The prevalence of neurological dieases, including neurodegenerative, neurotraumatic disorders, and neuroinflammatory conditions, has been rising due to global population aging demographics. A key factor in the pathogenesis these disorders is hyperaccumulation reactive oxygen nitrogen species (RONS). Nanozymes have emerged as promising candidates for neurotherapeutic applications owing their exceptional catalytic activity stability. Of particular note ability cross blood‐brain...

Abstract Light plays a direct crucial role in the switch between sleep and arousal regulation of physiology behaviour, such as circadian rhythms emotional change. Artificial lights, which are different from natural light sources with continuous spectrum, composed three single-colour lights increasingly applied modern society. However, vivo research on mechanisms blue light-regulated is still insufficient. In this work, we detected effects inserting white or for 1 h during dark period...

Some previous studies have shown that PLOD2 has some value in tumorigenesis. However, the broad significance of not been discussed depth. This study was aimed at elaborated and summarized various tumors. First, we integrated GTEx, The Cancer Genome Atlas Cell Line Encyclopedia databases to analyze expression PLOD2, found it expressed differently normal tissues significantly highly most tumors compared with tissues. Second, our analysis revealed negatively correlated prognosis several For...

Nanozymes are a class of nanomaterials that can specifically mimic the structures and catalytic activities as well overcome limitations natural enzymes have hence been considered competitive alternative to enzymes. At present, plenty nanozymes, especially those with peroxidase (POD)-like activity, extensively explored for biosensing. In this work, we proposed polyoxometalate-based heterojunction GdP5W30O110@WS2 nanoclusters (NCs) exert intrinsic POD-like activity even under harsh conditions....

The rapid development of image processing technology and the improvement computing power in recent years have made deep learning one main methods for plant disease identification. Currently, many neural network models shown better performance Typically, model needs to be achieved by increasing depth network. However, this also increases computational complexity, memory requirements, training time, which will detrimental deployment on mobile devices. To address problem, a novel lightweight...

Technical and vocational education training (TVET) is essential worldwide due to its prominent role in preparing the skilled workforce participate economic development. This article reports on TVET situation Pakistan. First, it historical developments of has been given priority policy documents since independence Pakistan, but real practical work done last two decades. National provincial governments have formulated many new policies improve created governing authorities regulate it. results...