A5068095967- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Polymer Surface Interaction Studies
- Retinal and Macular Surgery
- Corneal Surgery and Treatments
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Bone Tissue Engineering Materials
- Antimicrobial agents and applications
- Marine Biology and Environmental Chemistry
- Electrospun Nanofibers in Biomedical Applications
- Corneal surgery and disorders
- Advanced Drug Delivery Systems
- Surgical Sutures and Adhesives
- Silicone and Siloxane Chemistry
- Advanced Nanomaterials in Catalysis
- Advanced Polymer Synthesis and Characterization
- Dendrimers and Hyperbranched Polymers
- Anorectal Disease Treatments and Outcomes
- Advanced biosensing and bioanalysis techniques
- Surface Modification and Superhydrophobicity
- Anesthesia and Pain Management
- 3D Printing in Biomedical Research
- Nanocluster Synthesis and Applications
Wenzhou Medical University
2016-2025
Affiliated Eye Hospital of Wenzhou Medical College
2016-2025
Wenzhou Central Hospital
2024
Chinese Academy of Sciences
2014-2023
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2022
Wenzhou University
2014-2021
He Eye Hospital
2014-2021
Wenzhou Institute of Industrial Science
2014-2021
Shanghai Tenth People's Hospital
2018
Tongji University
2018
The adherence of bacteria and the formation biofilm on implants is a serious problem that often leads to implant failure. A series antimicrobial coatings have been constructed resist bacterial or kill through contact with release antibacterial agents. accumulation dead facilitates further contamination development. Herein, we designed novel, reversibly switchable bactericidal antifouling surface surface-initiated reversible addition–fragmentation chain transfer (RAFT) polymerization combine...
Posterior capsular opacification (PCO), the most common complication after cataract surgery, is caused by proliferation, migration and differentiation of residual lens epithelial cells (LECs) on surface intraocular (IOL). Although drug-loaded IOLs have been successfully developed, PCO prevention efficacy still limited due to lack targeting low bioavailability. In this investigation, an exosome-functionalized IOL was developed for effective utilizing homologous high biocompatibility exosome....
In this work, we report a new approach to prepare high gel performance hydrogels which are used as ionic strength-sensitive drug release systems. Succinic anhydride (SA)-modified xanthan (XG-SA) derivatives were prepared and confirmed by Fourier transform-infrared spectroscopy proton nuclear magnetic resonance spectroscopy. Rheological measurements showed that the storage moduli (G') loss (G'') of XG-SA much higher than native XG suggesting stability hydrogels. could form stable when content...
Posterior capsular opacification (PCO) is the main complication after intraocular lens (IOL) implantation in cataract surgery, which result of epithelial cell (LEC) adhesion, proliferation and migration on IOL at capsule interface. Hydrophilic surface modification, such as heparinization, decreases has been commercialized used clinically. However, clinical long-term observation results show no significant difference between pristine heparinized IOLs.To prevent PCO over long time span, we...
Abstract Endothelialization and antithrombogenicity are two key issues in stent implantation. The layer‐by‐layer (LbL) deposition of anticoagulant heparin cell compatible collagen was explored to develop a multilayered coating with synergic property fast endothelialization. quartz crystal microbalance dissipation (QCM‐D), UV spectrometer, spectroscopic ellipsometry, scanning electron microscopy, confocal laser microscopy investigations indicate that the LbL technique, which based on...
Once a biomedical implant is implanted into human body, proteins and bacteria can easily colonize the implant, subsequently, biofilm grow on surface. A protect inhabiting against macrophages neutrophil cell attack from host immune system. The most important issue for artificial antibacterial surfaces accumulation of corpse after they are killed by contact, which promotes further adhesion formation. Therefore, we constructed novel multifunctional bactericidal fouling release surface through...
Abstract: Infections after surgery or endophthalmitis are potentially blinding complications caused by bacterial adhesion and subsequent biofilm formation on the intraocular lens. Neither single-function anti-adhesion surface nor contacting killing can exhibit ideal antibacterial function. In this work, a novel (2-(dimethylamino)-ethyl methacrylate- co -2-methacryloyloxyethyl phosphorylcholine) (p (DMAEMA- -MPC)) brush was synthesized "grafting from" method through reversible–addition...
Posterior capsular opacification (PCO) is the most important complication in cataract phacoemulsification and intraocular lens (IOL) implantation surgery, mainly stemming from adhesion, proliferation, transdifferentiation of postsurgically residual epithelial cells (LECs). Previous investigations focused on hydrophilic surface modification IOLs for PCO prevention, such as heparinization. However, long-term clinical show that there no significant difference between pristine heparinized IOLs....
Abstract Dry eye disease (DED) is the most common in ophthalmic consultation except for refractive errors. Therefore, an exploration of valid and alternative therapeutic interventions essential to feed urgent medical need. It has been demonstrated that oxidative stress causes multiple adverse effects pathogenesis DED, thence alleviating effective strategy DED treatment. Herein, we developed a cerium oxide nanozyme combined with branched poly(ethylene imine)-graft-poly(ethylene glycol)...
Posterior capsule opacification is one of the complications cataract surgery caused by adhesion and reproduction residual human lens epithelial cells (HLECs) on posterior capsule.
Posterior capsule opacification (PCO) is a significant complication of intraocular lens (IOL) implantation in cataract surgery, which the adhesion and proliferation epithelial cells (LECs) on IOL surface play important roles. In present study, highly swollen hyaluronic acid (HA)/chitosan (CHI) polyelectrolyte multilayer was fabricated via layer by technique. Quartz crystal microbalance with dissipation (QCM-D) results not only show successful construction multilayer, but also indicate its...
As an acute ophthalmic infection, bacterial keratitis (BK) can lead to severe visual morbidity, such as corneal perforation, intraocular and permanent opacity, if rapid effective treatments are not available. In addition eradicating pathogenic bacteria, protecting tissue from oxidative damage promoting wound healing by relieving inflammation equally critical for the efficient treatment of BK. Besides, it is very necessary improve bioavailability drugs enhancing ocular surface adhesion...