A5046477669- Connective tissue disorders research
- Electrospun Nanofibers in Biomedical Applications
- Sulfur-Based Synthesis Techniques
- Silk-based biomaterials and applications
- Asymmetric Synthesis and Catalysis
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Reactions
- Supramolecular Self-Assembly in Materials
- Cellular Mechanics and Interactions
- Chemical Synthesis and Analysis
- Organic Chemistry Cycloaddition Reactions
- Protease and Inhibitor Mechanisms
- Bone Tissue Engineering Materials
- Coordination Chemistry and Organometallics
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Click Chemistry and Applications
- Synthesis of Organic Compounds
- Fluorine in Organic Chemistry
- Traditional and Medicinal Uses of Annonaceae
- Polymer Surface Interaction Studies
- RNA Interference and Gene Delivery
- Vanadium and Halogenation Chemistry
- Hydrogels: synthesis, properties, applications
- Diet, Metabolism, and Disease
- Aortic Disease and Treatment Approaches
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2016-2025
Universidad de Valladolid
2016-2025
Universidad Autónoma de Madrid
1992-2002
The versatility of 3D bioprinting techniques has demonstrated great potential for the development artificial engineered tissues that more closely resemble native tissues. Despite this, challenges remain as regards search new bioinks embrace all complex parameters this technique demands. In an attempt to develop such advanced material, a novel smart material based on elastin-like recombinamers (ELRs) been developed by molecularly programming its sequence exhibit sequential three-stage...
Spatiotemporal control of vascularization and innervation is a desired hallmark in advanced tissue regeneration. For this purpose, we design 3D model scaffold, based on elastin-like recombinamer (ELR) hydrogels. This contains two interior well-defined areas, small cylinders, with differentiated bioactivities respect to the bulk. Both are constructed protease sensitive ELR fast-proteolyzed domain, but one bears VEGF-mimetic peptide (QK) other laminin-derived pentapeptide (IKVAV), promote...
The search for new and biocompatible materials with high potential improvement is a challenge in gene delivery applications. A cell type specific vector made of elastin-like recombinamer (ELR) aptamers has been specifically designed the intracellular therapeutic material breast cancer therapy. lysine-enriched ELR was constructed complexed plasmid DNA to give positively charged stable polyplexes. Physical characterization these polyplexes showed particle size around 140 nm zeta approximately...
A wide range of smart surfaces with novel properties relevant for biomedical applications have been developed recently. Herein we focus on thermoresponsive that switch between cell-adherent and nonadherent states their cell harvesting. These are obtained by covalently coupling a tailored elastin-like recombinamer onto glass means the well-known widely applied Click Chemistry methodology. The resulting recombinamer-functionalized characterized water contact angle measurements, XPS TOF-SIMS....
Regioselective mono and dihalogenations of amino, hydroxy methoxy pyridines (2-, 3-, 4-substituted) as well 2,6-dimethoxy pyridine with N-bromosuccinimide in different solvents have been studied. Reactivity the substrates decreases order amino>hydroxy>methoxy regioselectivity depends on position substituent (2-substituted > 3-substituted). In most cases we obtained monobrominated derivatives regioselectively high yields. Hydroxy amino can also be dibrominated almost quantitative yield 2...
In this work, well-defined elastin-like recombinamers (ELRs) were studied as a choice to the existing nonviral vectors due their biocompatibility and ease of scale-up. Functional motifs, namely penetratin LAEL fusogenic peptides incorporated into basic ELR sequence, imidazole groups subsequently covalently bound obtaining ELRs with new functionalities. Stable polyplexes composed plasmid DNA formed. A particle size around 200 nm zeta potential up nearly +24 mV made them suitable for gene...
The reactions of the lithium (S)-α-(methylthio)-2-(p-toluenesulfinyl)benzyl carbanion with (S)-N-p-tolylsulfinyl aldimines evolve in a completely stereoselective manner providing one-step synthesis enantiomerically pure anti-1,2-disubstituted 1,2-amino sulfide derivatives.
Hetero Diels−Alder (HDA) cycloaddition of chiral 1-p-tolylsulfinyl-1,3-pentadiene with benzyl nitrosoformate, under mild conditions, yields 2H-1,2-oxazine 3 complete regioselectivity and π-facial diastereoselectivity. Sequential osmylation protection the resulting glycol gives oxazine 5 which is directly transformed into enantiomerically pure 1,4,5-trideoxy-1,4-imino-l-ribitol 8 by reduction Pd/C.
Abstract Here, we describe a procedure to manufacture smart hybrid probes that exhibit tunable optical properties as function of multiple environmental variations. Initially, achieved one‐pot synthesis gold‐PREP (photo‐responsive elastin‐like polymer) conjugate Gold‐AzoGlu15 via reduction auric acid in the presence PREP AzoGlu15 . Outstandingly, exhibited pH and temperature sensitiveness. However, was not UV‐vis sensitive. We noticed photo‐isomerisation azobenzene moieties could be detected...