A5100320117- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Hormonal Regulation and Hypertension
- Anesthesia and Neurotoxicity Research
- Nerve injury and regeneration
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroscience and Neuropharmacology Research
- MicroRNA in disease regulation
- Vaccine Coverage and Hesitancy
- Regional Development and Environment
- Treatment of Major Depression
- Ginseng Biological Effects and Applications
- Adipose Tissue and Metabolism
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- Dietary Effects on Health
- Nicotinic Acetylcholine Receptors Study
- Nutrition and Health in Aging
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disease Mechanisms and Treatments
- Pain Mechanisms and Treatments
- Cancer survivorship and care
- Bioactive Compounds and Antitumor Agents
- Genomics, phytochemicals, and oxidative stress
Jiangsu Provincial Center for Disease Control and Prevention
2021-2025
Air Force Medical University
2025
Nantong University
2018-2022
China-Japan Friendship Hospital
2019
Nanjing Drum Tower Hospital
2017-2019
Harbin Medical University
2009
Second Affiliated Hospital of Harbin Medical University
2009
First Affiliated Hospital of Sichuan Medical University
2005
Southwest Medical University
2005
Depression is a widespread chronic medical illness affecting thoughts, mood, and physical health. However, the limited delayed therapeutic efficacy of monoaminergic drugs has led to intensive research efforts develop novel antidepressants. ARN-3236 first potent selective inhibitor salt-inducible kinase 2 (SIK2). In this study, multidisciplinary approach was used explore antidepressant-like actions in mice. Chronic social defeat stress (CSDS) unpredictable mild (CUMS) models depression,...
Abstract Introduction The most striking feature of depression is sadness and a loss interest in activities, which represents major cause disability globally. Therefore, it necessary to identify novel antidepressants for clinical practice. Ginsenoside Rh2 (Rh2) one the bioactive ginsenosides that can be extracted from Panax ginseng has been demonstrated improve both memory learning. purpose this study was provide broad insight into mechanisms underlying gain greater insights antidepressant...
Evidence regarding the comparative safety of different COVID-19 vaccines remains limited. This study aims to characterize and compare profiles five in terms adverse reactions after immunization. We conducted a retrospective analysis reported among adults aged 18-59 years from nine clinical trials. The analyzed included inactivated, recombinant protein, intranasal influenza-vectored, aerosolized intramuscular Ad5 vectored vaccines. Factor association rule were used reaction patterns, while...
Caloric restriction (CR) increases lifespan, retards physiological signs of aging, and delays a variety diseases. Reduction inflammatory response was proposed as one the molecular mechanisms for how CR exerts beneficial effects. The present study investigated effects on postoperative pain in rats. Adult nonobese rats were divided into two dietary groups, an ad libitum fed group (AL) caloric that provided with 60% food intake AL After 6 weeks, behaviors inflammation induced by plantar...
Objective: As one of the most prevalent psychiatric disorders, exact pathogenesis depression remains elusive. Therefore, there is an urgent need to identify novel antidepressants for effective treatment. MicroRNA-124 (miR-124), abundant miRNA in brain tissue, plays a key effect on adult neurogenesis and neuronal differentiation. However, mechanism miR-124 has not been clarified so far. The aim this study provide broad insight into mechanisms underlying depression. Methods: In study, we used...
Preoperative anxiety is common in patients undergoing elective surgery and closely related to postoperative hyperalgesia. In this study, a single prolonged stress model was used induce preoperative anxiety-like behavior rats 24 h before the surgery. We found that exacerbated pain elevated level of serum corticosterone. Previous studies have shown glucocorticoid associated with synaptic plasticity, decreased spinal GABAergic activity can cause hyperalgesia rodents. Here, rats' lumbar cord...
As a well-known multimodal-acting antidepressant, vortioxetine is thought to aim at several serotonin (5-HT) receptors and the 5-HT transporter. However, recently more proteins besides are being reported participate in antidepressant mechanism of vortioxetine. widely known nuclear hormone receptor, peroxisome proliferator activated receptor α (PPARα) possesses transcriptional activity very important brain. Several reports have suggested that hippocampal PPARα implicated responses. Here we...
Abstract Background General anesthesia and increasing age are two main risk factors for postoperative cognitive dysfunction (POCD). Effective agents the prevention or treatment of POCD urgently needed. L-655,708, an inverse agonist α5 subunit-containing γ-aminobutyric acid subtype A (α5GABA ) receptors, can prevent anesthesia-induced memory deficits in young animals. However, there is a lack evidence its efficacy old Methodology Young (3- to 5-month-old) (18- 20-month-old) mice were given...
Abstract Elucidating the molecular mechanism underlying hyperactivity of hypothalamic–pituitary–adrenal axis during chronic stress is critical for understanding depression and treating depression. The secretion corticotropin-releasing hormone (CRH) from neurons in paraventricular nucleus (PVN) hypothalamus controlled by salt-inducible kinases (SIKs) CREB-regulated transcription co-activators (CRTCs). We hypothesized that SIK-CRTC system PVN might contribute to pathogenesis Thus, present...
The Chengdu metropolitan area serves as the hub of western region’s development and pole Chengdu-Chongqing twin-city economic circle. is in stage agglomeration well diffusion rapid urbanization globalization. As a medium-sized city area, Ziyang must determine its urban function positioning future based on spatial structure characteristics for industrial layout optimization coordinated entire more importantly, to maximize benefits.