A5088212023- Pain Management and Treatment
- Hippo pathway signaling and YAP/TAZ
- Pain Mechanisms and Treatments
- Glycogen Storage Diseases and Myoclonus
- Bone Metabolism and Diseases
- Cancer Cells and Metastasis
- Myofascial pain diagnosis and treatment
- Autoimmune Neurological Disorders and Treatments
- Genetics and Neurodevelopmental Disorders
- Apelin-related biomedical research
- Bone and Dental Protein Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Kruppel-like factors research
- MicroRNA in disease regulation
- Osteoarthritis Treatment and Mechanisms
- Epigenetics and DNA Methylation
- Mesenchymal stem cell research
- Carbon Nanotubes in Composites
- Fiber-reinforced polymer composites
- Transcranial Magnetic Stimulation Studies
- Cancer, Hypoxia, and Metabolism
- Pharmacology and Obesity Treatment
- Connective tissue disorders research
- Hematopoietic Stem Cell Transplantation
- Petroleum Processing and Analysis
Max Planck Institute for Molecular Biomedicine
2019-2024
University of Münster
2019-2023
University of Calgary
2023
Justus-Liebig-Universität Gießen
2014-2022
University of Liverpool
2015
University College London
2015
Bone stroma contributes to the regulation of osteogenesis and hematopoiesis but also fracture healing disease processes. Mesenchymal stromal cells from bone (BMSCs) represent a heterogenous mixture different subpopulations with distinct molecular functional properties. The lineage relationship between BMSC subsets their by intrinsic extrinsic factors are not well understood. Here, we show mouse genetics, ex vivo cell differentiation assays, transcriptional profiling that BMSCs metaphysis...
Abstract Developmental osteogenesis, physiological bone remodelling and fracture healing require removal of matrix cellular debris. Osteoclasts generated by the fusion circulating monocytes degrade bone, whereas identity cells responsible for cartilage resorption is a long-standing controversial question. Here we show that degradation chondrocyte phagocytosis are mediated fatty acid binding protein 5-expressing representing septoclasts, which have mesenchymal origin not derived from...
Blood vessels are integrated into different organ environments with distinct properties and physiology (Augustin Koh, 2017). A striking example of organ-specific specialization is the bone vasculature where certain molecular signals yield opposite effect as in other tissues (Glomski et al., 2011; Kusumbe 2014; Ramasamy 2014). Here, we show that transcriptional coregulators Yap1 Taz, components Hippo pathway, suppress vascular growth hypoxic microenvironment bone, contrast to their...
Opsoclonus-myoclonus syndrome (OMS) is a rare and primarily immune-mediated disease in children adults. The main symptoms include opsoclonus, myoclonus ataxia. In children, the also irritability, and, over long-term course, learning behavioural disturbances. OMS can be idiopathic, parainfectious or occur as paraneoplastic (tumour-associated) syndrome. Paraneoplastic almost exclusively associated with neuroblastoma, whereas adults, small cell lung cancer breast are underlying tumours. An...
Skeletal stem and progenitor cells (SSPCs) perform bone maintenance repair. With age, they produce fewer osteoblasts more adipocytes leading to a loss of skeletal integrity. The molecular mechanisms that underlie this detrimental transformation are largely unknown. Single-cell RNA sequencing revealed Notch signaling becomes elevated in SSPCs during aging. To examine the role increased activity, we deleted Nicastrin, an essential pathway component, vivo. Middle-aged conditional knockout mice...
The vasculature of the skeletal system is crucial for bone formation, homoeostasis and fracture repair, yet diversity specialization bone-associated vessels remain poorly understood. Here we identify a specialized type post-arterial capillary, termed R, involved in remodelling. Type R capillaries emerge during adolescence around trabecular bone, possess distinct morphology molecular profile, are associated with osteoprogenitors bone-resorbing osteoclasts. Endothelial cell-specific...
Complex regional pain syndrome is a severe complication following trauma that associated with vasomotor, sudomotor and sensory disturbances in an affected limb or region of the body. The exact physiopathology not fully understood yet. Recently, autoantibody findings suggested immune-mediated disease. We here describe two otherwise treatment-resistant patients complex high-titre beta2 adrenergic receptor autoantibodies, who did respond to plasmapheresis. Both showed strong improvement...
Myelofibrosis and osteosclerosis are fibrotic diseases disrupting bone marrow function that occur in various leukemias but also response to non-malignant alterations hematopoietic cells. Here we show endothelial cell-specific inactivation of the
Abstract Complex regional pain syndrome (CRPS) is an inadequate local response after a limb trauma, which leads to severe and autonomic trophic changes of the affected limb. Autoantibodies directed against human β2 adrenergic muscarinic M2 receptors (hβ2AR hM2R) have been described in CRPS patients previously. We analyzed sera from for autoantibodies hβ2AR, hM2R, endothelial cells investigated functional effects purified IgG, derived 13 with CRPS, on cells. Eleven healthy controls, 7 radial...
Asphaltenes are a complex mixture of aromatic organic molecules found in petroleum and coal.Recently, asphaltenes have been increasingly studied as potential precursors for carbon fibres.State-of-the-art commercially available fibres made from polyacrylonitrile (PAN), pitch, rayon, with each precursor material having its unique range properties.Because the low cost Alberta oil sands (AOAs), AOAs represent cost-effective alternative that would make more accessible to wide...