A5013615880- Antioxidant Activity and Oxidative Stress
- Schizophrenia research and treatment
- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Mental Health and Psychiatry
- Free Radicals and Antioxidants
- Chronic Disease Management Strategies
- Psychiatric care and mental health services
- Primary Care and Health Outcomes
- Health disparities and outcomes
- Carcinogens and Genotoxicity Assessment
- Emergency and Acute Care Studies
- Vitamin C and Antioxidants Research
- Management and Marketing Education
- Mental Health Treatment and Access
- Biotechnology and Related Fields
- Folate and B Vitamins Research
- Phytochemicals and Antioxidant Activities
- Biomedical Text Mining and Ontologies
- Chemistry and Chemical Engineering
- Pharmaceutical Economics and Policy
- Cardiac Health and Mental Health
- Birth, Development, and Health
- Medical Education and Admissions
- Organ Transplantation Techniques and Outcomes
University of Pittsburgh Medical Center
2025
University of Liverpool
1995-2024
Bronllys Hospital
2022-2024
University of South Wales
2024
Circle (United States)
2009
Shrewsbury and Telford Hospital NHS Trust
2004-2006
Glan Clwyd Hospital
2004
University of Wales
2004
North Yorkshire County Council
2001
University of Leeds
1997-2000
Oxidative DNA damage is important in aging and the degenerative diseases of such as cancer. Estimates commonly rely on measurements 8-oxo-2′-deoxyguanosine (oxo 8 dG), an adduct that occurs also excreted urine after repair. Here we examine difficulties inherent analysis oxo dG, identify sources artifacts, provide solutions to some common methodological problems. A frequent criticism has been phenol extraction artificially increases measured level dG. We found contributes a real but minor...
Peroxynitrite, a powerful mutagenic oxidant and nitrating species, is formed by the near diffusion-limited reaction of ·NO O 2⨪ during activation phagocytes. Chronic inflammation induced phagocytes major contributor to cancer other degenerative diseases. We examined how γ-tocopherol (γT), principal form vitamin E in United States diet, α-tocopherol (αT), supplements, protect against peroxynitrite-induced lipid oxidation. Lipid hydroperoxide formation liposomes (but not isolated low-density...
Introduction Antipsychotic medication is increasingly prescribed to patients with serious mental illness. Patients illness often have cardiovascular and metabolic comorbidities, antipsychotics independently increase the risk of cardiometabolic disease. Despite this, many are discharged primary care without planned psychiatric review. We explore perceptions healthcare professionals managers/directors policy regarding reasons for increasing prevalence management in care. Methods Qualitative...
The ability of dietary supplementation with carotenoids to protect chick tissues against oxidative stress in vitro was examined. Male Leghorn chicks were fed on diets supplemented (100 mg supplement/kg diet) either β-carotene, zeaxanthin (β,β-carotene-3,3'-diol), canthaxanthin (β,β-carotene-4,4'-dione) or α-tocopherol, a control diet, from 1 d old until 37 age. Tissues (liver, heart, skeletal muscle and plasma) removed assayed for total α-tocopherol content portions subjected by incubation...
Structured medication reviews (SMRs), introduced in the United Kingdom (UK) 2020, aim to enhance shared decision-making optimisation, particularly for patients with multimorbidity and polypharmacy. Despite its potential, there is limited empirical evidence on implementation of SMRs, challenges faced process. This study part a larger DynAIRx (Artificial Intelligence dynamic prescribing optimisation care integration multimorbidity) project which aims introduce Artificial (AI) SMRs develop...
Abstract Background Codelists play a crucial role in ensuring accurate and standardized communication within healthcare. However, preparation of high-quality codelists is rigorous time-consuming process. The literature focuses on transparency clinical overlooks the utility automation. Methods (Automated Framework Design Use-case: DynAIRx) Here we present Codelist Generation that can automate generation with minimal input from experts. We demonstrate process using specific project, DynAIRx,...
Structured Medication Reviews (SMRs) are intended to help deliver the NHS Long Term Plan for medicines optimisation in people living with multiple long-term conditions and polypharmacy. It is challenging gather information needed these reviews due poor integration of health records across providers there little guidance on how identify those patients most urgently requiring review.
Background: Long-term use of antipsychotics confers increased risk cardiometabolic disease. Ongoing need should be reviewed regularly by psychiatrists. Aim: To explore trends in antipsychotic management general practice, and proportions patients prescribed receiving psychiatrist review. Design Setting: A serial cross-sectional study using linked practice hospital data Wales (2011-2020). Method: Participants were adults (≥18 years) registered with practices Wales. Outcome measures prevalence...
Conference Article| February 01 1995 Antioxidant activity of carotenoids in phosphatidylcholine vesicles: chemical and structural considerations ALAN A. WOODALL; WOODALL 1Department Medicine, University Liverpool, P.O. Box 147, Liverpool L69 3BX, U.K.2Department Biochemistry, U.K. Search for other works by this author on: This Site PubMed Google Scholar GEORGE BRITTON; BRITTON 2Department MALCOLM J. JACKSON Biochem Soc Trans (1995) 23 (1): 133S. https://doi.org/10.1042/bst023133s Views Icon...
The International Journal of Integrated Care (IJIC) is an online, open-access, peer-reviewed scientific journal that publishes original articles in the field integrated care on a continuous basis. IJIC has Impact Factor 2.60 (2023 JCR, received June 2024) 20th Anniversary Issue was published 2021.
Implications for policy makers and future researchNurse led hospital at home or early discharge schemes patients with COPD should be prioritised over the type of nurse models chronic disease management that have been studied to date.There is little evidence available present support evaluated.Existing services providing this sort care robustly evaluated against aims particular service.The around long term intensive case readmission currently equivocal requires further study.The potential...
Abstract Introduction Structured medication reviews (SMRs), introduced in the United Kingdom (UK) 2020, aim to enhance shared decision-making optimisation, particularly for patients with multimorbidity and polypharmacy. Despite its potential, there is limited empirical evidence on implementation of SMRs, challenges faced process. This study part a larger DynAIRx (Artificial Intelligence dynamic prescribing optimisation care integration multimorbidity) project which aims introduce Artificial...
Abstract Background Long-term use of antipsychotics confers increased risk cardiometabolic disease. Ongoing need should be reviewed regularly by psychiatrists. Aim To explore trends in antipsychotic management general practice, and proportions patients prescribed receiving psychiatrist review. Design Setting A serial cross-sectional study using linked practice hospital data Wales (2011-2020). Method Participants were adults (≥18 years) registered with practices Wales. Outcome measures...
Cardiovascular risk was evaluated in patients admitted to rural inpatient psychiatric services over a one-year period sparsely populated region of the United Kingdom. Care records were analysed for factor recording, and cardiovascular estimated using QRISK3 calculator, which estimates 10-year myocardial infarction or stroke. Of eligible patients, recording as part routine care completed 86% possible inputs, enabling QIRSK3 estimation all patients. this group significantly raised relative an...
Aims and Method In order to examine the opportunities for senior house officers (SHOs) undertake emergency psychiatric assessments we conducted a retrospective cohort study of such in district general hospital. Results Senior few self-harm compared with liaison nurses ( P < 0.001), were involved only 40% referrals where opinion was requested. continue more out hours than any other group 0.01). Clinical Implications Although introduction has improved capacity reduced waiting times...
Atypical antipsychotics are effective treatments for patients with psychotic disorders, but prolonged use can increase the risk of long‐term adverse effects such as type 2 diabetes, obesity, hyperlipidaemia and cardiovascular disease. This article provides guidance to help GPs manage on these medications, discusses how service reconfiguration is urgently needed improve care who currently falling through gap between primary secondary review.