A5018240227- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Biochemical and Molecular Research
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
Southern Medical University
2020-2022
Nanfang Hospital
2020-2022
Plenty of studies showed that the immune system was associated with cancer initiation and progression. This study aimed to explore prognostic biomarkers from immune-related genes (IRGs) in oral squamous cell carcinoma (OSCC).RNA-seq data were downloaded The Cancer Genome Atlas (TCGA) IRGs transcription factors (TFs) extracted. Then, co-expression network between TFs constructed using "WGCNA" package R software. Furthermore, a gene expression signature according predict OSCC prognosis its...
Abstract Oral squamous cell carcinoma (OSCC) is the most common oral cancer. The molecular mechanisms of this disease are not fully understood. Our previous studies confirmed that dysregulated function long non-coding RNA (lncRNA) AC007271.3 was associated with a poor prognosis and overexpression promoted proliferation, migration, invasion, inhibited apoptosis in vitro, tumor growth vivo. However, underlying dysregulation remained obscure. In study, our investigation showed functioned as...
Objectives. Many studies have shown that dysregulation of metabolism contributes to oncogenesis. However, the exact roles metabolism-related genes (MRGs) in oral squamous cell carcinoma (OSCC) remain unclear. Thus, we aimed identify a prognostic signature related MRGs OSCC. Methods. The gene sequencing data OSCC samples and MRG set were downloaded from Cancer Genome Atlas (TCGA) Molecular Signatures Database (MSigDB). Wilcoxon rank-sum test was used differentially expressed MRGs. Then,...
Abstract Background : Oral squamous cell carcinoma (OSCC) is the most common oral cancer. Our previous studies confirmed that dysregulation function of long non-coding RNA (lncRNA) AC007271.3 was associated with a poor prognosis and overexpression promoted proliferation, migration, invasion inhibited apoptosis in vitro, tumor growth vivo. However, underlying mechanisms remained obscure. Methods Bioinformatics databases were used to predicted potential down-stream targeted verified by dual...