A5077708464- Pregnancy and preeclampsia studies
- Genetic and phenotypic traits in livestock
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Effects of Environmental Stressors on Livestock
- Reproductive Physiology in Livestock
- Wildlife Ecology and Conservation
- Reproductive System and Pregnancy
- Animal Behavior and Welfare Studies
University of Colorado Denver
2021-2022
United States Fish and Wildlife Service
2004-2005
Abstract Pregnancies complicated by severe, early-onset fetal growth restriction with abnormal Doppler velocimetry (FGRadv) have a sparse villous vascular tree secondary to impaired angiogenesis. As endothelial cell (EC) and stromal matrix interactions are key regulators of angiogenesis, we investigated the role placental on fetoplacental EC We developed novel model generating fibroblast (FB) cell-derived matrices (CDMs), allowing us interrogate placenta-specific human their effects found...
ABSTRACT Placentas from pregnancies complicated by severe early-onset fetal growth restriction (FGR) exhibit diminished vascular development mediated impaired angiogenesis, but underlying mechanisms remain unknown. In this study, we show that FGR endothelial cells demonstrate inherently reduced migratory capacity despite the presence of fibronectin, a matrix protein abundant in placental stroma displays abnormal organization placentas. Thus, hypothesized aberrant endothelial-fibronectin...