A5012445918- Suicide and Self-Harm Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Medicinal Plants and Bioactive Compounds
- Mental Health Treatment and Access
- Child and Adolescent Psychosocial and Emotional Development
- Traumatic Brain Injury Research
- S100 Proteins and Annexins
- Emergency and Acute Care Studies
- Smoking Behavior and Cessation
- Health disparities and outcomes
- Mental Health via Writing
- Insect and Pesticide Research
- COVID-19 and Mental Health
- Gun Ownership and Violence Research
- Axon Guidance and Neuronal Signaling
- Digital Mental Health Interventions
- Child and Adolescent Health
Columbia University
2022-2024
New York Psychoanalytic Society and Institute
2018-2024
New York State Psychiatric Institute
2018-2022
Brigham and Women's Hospital
2013-2017
C3 deficiency protects against hippocampal neurodegeneration and cognitive decline in aged APP/PS1 mice despite abundant Aβ plaques.
Abstract Objective As part of the National Suicide Prevention Lifeline’s crisis response system, Lifeline Crisis Chat Network (LCC) answers chats from hundreds thousands at‐risk individuals yearly. The study’s objective was to assess effectiveness these online interventions. Method Data 39,911 pre‐chat surveys and 13,130 linked pre‐ post‐chat completed by LCC chatters October 2017–June 2018 were analyzed. relationship several measures with chatter demographics, distress, suicidal ideation,...
Abstract Introduction Research has established that suicide‐related media can impact suicide rates both positively and negatively, supporting efforts to engage the in service of prevention. The goal current study is evaluate a prevention campaign implemented April 7–14, 2019 Oregon. Methods Several indices help‐seeking behavior risk were employed: Google Health API searches, National Suicide Prevention Lifeline (Lifeline) (currently known as 988 Crisis Lifeline) call volume, state mortality...
Adolescents' exposure to a peer's suicide has been found be associated with, as well predict, suicidal ideation and behavior. Although postvention efforts tend school-based, little is known about the impact of schoolmate's on school's student population overall. The present study seeks determine whether there excess psychological morbidity among students in school where schoolmate died by suicide, students' attitudes coping help-seeking strategies are more or less problematic such schools....
Specific content characteristics of suicide media reporting might differentially impact suicides in the population, but studies have not considered overarching theme respective stories and other relevant outcomes besides suicide, such as help-seeking behaviours.We obtained 5652 reports related to from 6 print, 44 broadcast 251 online sources Oregon Washington states, published between April 2019 March 2020. We conducted a analysis regarding their focus specific based on recommendations for...
Abstract: Background: Between April 7 and 14, 2019, the “Breaking Silence” media engagement campaign was launched in Oregon. Aims: We aimed to assess consistency of content related with guidelines quantitative footprint on Twitter (now X) over time. Method: Media items were analyzed regarding focus for suicide reporting compared other suicide-related reports published same time frame, as well Washington, control region. Tweets retrieved social footprint. Results: There n = 104 month, mainly...
Abstract: Background: Research indicates that the COVID-19 pandemic caused increases in psychological distress and suicidal ideation. Aims: To describe ways callers to National Suicide Prevention Lifeline (Lifeline) perceived have impacted them assess whether these COVID-19-related stress as contributing their thoughts. Method: Telephone interviews were conducted with 412 12 centers. Logistic regression analyses used examine associations between demographic factors individual stressors...
This study sought to identify current practices for the treatment of patients presenting with suicidal ideation or a recent suicide attempt in pediatric emergency departments (EDs) North America.From October 10, 2018, January 19, 2020, authors conducted cross-sectional online survey on medicine chiefs practicing United States and Canada.Forty-six (34%) 136 responded survey. The three most frequent improvements reported they would like see care young were easier access mental health personnel...
The complement system is an innate immune response to remove pathogens and cellular debris, has also been reported recently be involved in neurogenesis microglia-mediated synaptic pruning during brain development. Complement C3, central multiple pathways, elevated Alzheimer's disease (AD) appears contribute Abeta clearance by microglia. Recently, we demonstrated age-dependent synapse neuron loss CA3 of hippocampus aged C56BL/6 WT mice but not C3-deficient mice. C3 KO were less anxious had...
The complement cascade, part of the innate immune system, is designed to defend against pathogens. Complement proteins, including C3, help refine CNS neuronal connections via microglia-mediated pruning inappropriate synapses (Stevens et al., Cell 2007; Schafer Neuron, 2012). C3 upregulated in Alzheimer's disease (AD) and Down syndrome (DS) brain (Stoltzner Am J Pathol 2000) may contribute aberrant synapse elimination, recapitulating its role developing brain, and/or beta-amyloid clearance...
The complement system is a part of innate immune response to remove pathogens. Complement C3 pivotal component in multiple pathways. During development, proteins, including C3, help refine CNS neuronal connections via microglia-mediated pruning inappropriate synapses (Stevens et al., Cell 2007; Schafer Neuron, 2012). upregulated Alzheimer's disease (AD) and Down syndrome (DS) brain (Stoltzner Am J Pathol 2000) may contribute aberrant synapse elimination, recapitulating its role the...