A5101687454- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- RNA Research and Splicing
- HER2/EGFR in Cancer Research
- Surface Modification and Superhydrophobicity
- Cancer, Hypoxia, and Metabolism
- Gastric Cancer Management and Outcomes
- Spectroscopy and Chemometric Analyses
- Spectroscopy Techniques in Biomedical and Chemical Research
- Autism Spectrum Disorder Research
- Cancer, Stress, Anesthesia, and Immune Response
- Esophageal Cancer Research and Treatment
- Luminescence and Fluorescent Materials
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Obsessive-Compulsive Spectrum Disorders
- Gastrointestinal Tumor Research and Treatment
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- Genetics and Neurodevelopmental Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cytokine Signaling Pathways and Interactions
- Adhesion, Friction, and Surface Interactions
Zhejiang University of Technology
2023-2025
Qilu Hospital of Shandong University
2021-2025
Nanning Normal University
2024-2025
Nanjing Medical University
2012-2025
Jiangsu Province Hospital
2017-2025
Jiangsu University of Science and Technology
2022-2024
Northwest University
2024
Beijing Children’s Hospital
2020-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2022
Capital Medical University
2020-2022
Abstract Approximately half of the world’s 500,000 new oesophageal squamous-cell carcinoma (ESCC) cases each year occur in China. Here, we show whole-genome sequencing DNA and RNA 94 Chinese individuals with ESCC. We identify six mutational signatures (E1–E6), Signature E4 is unique ESCC linked to alcohol intake genetic variants alcohol-metabolizing enzymes. discover significantly recurrent mutations 20 protein-coding genes, 4 long non-coding RNAs 10 untranslational regions. Functional...
Genetic variations in interferon-gamma (IFN-γ) and its receptor (IFNγR) subunits are closely associated with the risk of colorectal cancer (CRC) survival after diagnosis. However, role loss IFN-γ or IFNγR function pathogenesis CRC remains unclear. Here, we investigated endogenous deficiency adenomatous polyposis coli (Apc)-mediated intestinal tumor by developing a variant Apc(Min/+) mice. The Apc(Min/+)IFN-γ(+/-) mice presented increased number size adenomas, 41.7% these developed...
Immune checkpoint blockade (ICB) has revolutionized the treatment of various cancer types. Despite significant preclinical advancements in understanding mechanisms, identifying molecular basis and predictive biomarkers for clinical ICB responses remains challenging. Recent evidence, both clinical, underscores pivotal role extracellular matrix (ECM) modulating immune cell infiltration behaviors. This study aimed to create an innovative classifier that leverages ECM characteristics enhance...
The anti-icing and drag-reduction properties of diverse microstructured surfaces have undergone extensive study over the past decade. Nonetheless, tough environments enforce stringent demands on composite characteristics superhydrophobic (SHS). In this study, fresh structures were fabricated a metal substrate by nanosecond laser machining technology, drawing inspiration from hardy plant Iridaceae. prepared sample surface mainly consists periodic microrhombus array irregular nanosheets. To...
Abstract A previous study classifies solid tumors based on collagen deposition and immune infiltration abundance, identifying a refractory subtype termed armored & cold tumors, characterized by elevated diminished infiltration. Beyond its impact infiltration, also influences tumor angiogenesis. This systematically analyzes the association between immuno‐collagenic subtypes angiogenesis across diverse cancer types. As result, exhibit highest angiogenic activity in lung adenocarcinoma...
Background/Aims: Resistance to trastuzumab remains a common challenge HER-2 positive breast cancer. Up until now, the underlying mechanism of resistance is still unclear. tRNA-derived small non-coding RNAs, new class RNA (sncRNAs), have been observed play an important role in cancer progression. However, relationship between fragments and unknown. Methods: We detected levels expression normal epithelial cell lines, trastuzumab-sensitive -resistant lines using high-throughput sequencing....
The self-healing superhydrophobic surfaces have attracted great interest owing to restoring superhydrophobicity without preparation crafts. However, the surface still faces dilemma of long repairing time. Especially in aqueous environments, are highly susceptible contamination and damage. In current study, a with ultrafast repairability was developed, which apply for drag reduction medium. prepared can recover only 30 s after severe physical chemical addition, this research pioneered...
Background/Aims: High levels of cancer stem cells (CSCs) in patients with triple-negative breast (TNBC) correlate risk poor clinical outcome and possibly contribute to chemoresistance metastasis highly malignant TNBC. Aberrant microRNA expression is associated the dysfunction self-renewal proliferation cells, while there little information about TNBC-specific microRNAs regulating CSC ability. Methods: Solexa deep sequencing was performed detect TNBC or non-TNBC microRNAs. Mammosphere...
Rationale: Whole-genome sequencing has identified many amplified genes in esophageal squamous-cell carcinoma (ESCC).This study investigated the role and clinical relevance of these ESCC.Methods: We collected ESCC non-tumor tissues from 225 individuals who underwent surgery.Clinical data were survival time was measured date diagnosis to last follow-up or death.Patient compared with immunohistochemical staining score using Kaplan-Meier methods hazard ratios calculated by Cox models.Cells gene...
Immune checkpoint blockade (ICB) has made remarkable achievements, but newly identified armored and cold tumors cannot respond to ICB therapy. The high prevalence of concomitant medications huge impact on immunotherapeutic responses, the clinical effects therapeutic outcome are still unclear.
Recent phase III randomized controlled trials have demonstrated that first-line immune checkpoint inhibitors (ICIs) improve prognosis in advanced HER-2-negative gastric cancer patients with programmed death ligand 1 (PD-L1) combined positive score (CPS) higher than 5. However, these findings are not confirmed real-world settings, and the benefits PD-L1 CPS < 5 remain controversial. In this multicenter, retrospective cohort study, data from across thirteen medical centers were analyzed by...
Placenta-specific protein 1 (Plac1) is a cancer/testis antigen that plays critical role in promoting cancer initiation and progression. However, the clinical significance mechanism of Plac1 progression remain elusive. Here, we report an important oncogenic prognostic factor, which physically interacts with Furin to drive breast invasion metastasis. We have shown expression positively correlates stage, lymph node metastasis, hormone receptor status, overall patient survival. Overexpression...
Background/Aims: Trastuzumab is an important treatment used for patients with Her-2-positive breast cancer, but increasing incidence of trastuzumab resistance has been observed clinically during the past decade. Aberrant microRNA (miR) expression levels are correlated prognosis and response to in cancer. MiR-129-5p downregulated trastuzumab-resistant human cancer cells (JIMT-1), its potential function underlying mechanism remain unclear. Methods: Quantitative RT-PCR (qRT-PCR) was determine...
Triple-negative breast cancer (TNBC), an intrinsic subtype of cancer, is characterized by aggressive pathology and shorter overall survival. Yet there no effective therapy for these patients. Breast stem cells (BCSCs) in TNBC may account treatment failure. It urgent to identify new therapeutic targets TNBC. tRNA-derived small noncoding RNAs (tDRs) represent a class (sncRNA), which have been reported some human diseases biological processes. However, detailed information about the...
Chronic obstructive pulmonary disease (COPD) is a major global epidemic with increasing incidence worldwide. The pathogenesis of COPD involved mitochondrial autophagy. Recently, it has been reported that FUN14 domain containing 1 (FUNDC1) mediator Therefore, we hypothesized FUNDC1 was in cigarette smoke (CS)-induced progression by regulating In vitro extract (CSE)-treated human bronchial epithelial cell (hBEC) Beas-2B line and vivo CS-induced mouse models were developed, which expression...
Abstract Radiotherapy remains the mainstay for treatment of various types human cancer; however, clinical efficacy is often limited by radioresistance, in which underlying mechanism largely unknown. Here, using esophageal squamous cell carcinoma (ESCC) as a model, we demonstrate that guanine nucleotide exchange factor 2 (VAV2), overexpressed most cancers, plays an important role primary and secondary radioresistance. We have discovered first time VAV2 required Ku70/Ku80 complex formation...
Autism is the most common clinical developmental disorder in children. The childhood autism rating scale (CARS) and autistic behavior checklist (ABC) are commonly used assessment scales for diagnosing autism. However, diagnostic validations corresponding cutoffs CARS ABC individuals with suspected spectrum (ASD) remain unclear. Furthermore, ASD China, it remains unclear whether a better tool than ABC. Also current cutoff points suitable accurate diagnosis of ASD.To investigate validity based...
Increasing evidence has shown that physical exercise remarkably inhibits oncogenesis and progression of numerous cancers exercise-responsive microRNAs (miRNAs) exert a marked role in exercise-mediated tumor suppression. In this research, expression prognostic values miRNAs were examined breast cancer (BRCA) further pan-cancer types. addition, multiple independent public in-house cohorts, vitro assays involving multiple, macrophages, fibroblasts, cells, vivo models utilized to uncover the...