A5062001006- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Regulation of Appetite and Obesity
- Hypothalamic control of reproductive hormones
- Cancer, Stress, Anesthesia, and Immune Response
- Telomeres, Telomerase, and Senescence
- Retinal Diseases and Treatments
- DNA Repair Mechanisms
- DNA and Nucleic Acid Chemistry
- Micro and Nano Robotics
- RNA and protein synthesis mechanisms
- Advanced Radiotherapy Techniques
- Optical Imaging and Spectroscopy Techniques
- Electrohydrodynamics and Fluid Dynamics
- Experimental and Theoretical Physics Studies
- Retinal Development and Disorders
- Spectroscopy Techniques in Biomedical and Chemical Research
Seoul National University
2020-2025
Yeungnam University
2025
Namseoul University
2025
Konkuk University
2022
Kyonggi University
2011
Neuropeptide Y (NPY) is highly abundant in the brain and involved various physiological processes related to food intake anxiety, as well human diseases such obesity cancer. However, molecular details of interactions between NPY its receptors are poorly understood. Here, we report a cryo-electron microscopy structure NPY-bound neuropeptide Y1 receptor (Y1R) complex with Gi1 protein. The C-terminal segment forming extended conformation binds deep into Y1R transmembrane core, where amidated...
Abstract Neuropeptide FF Receptor 2 (NPFFR2), a G-protein-coupled receptor, plays role in pain modulation and diet-induced thermogenesis. While NPFFR2 is strongly activated by neuropeptides (NPFFs), it shows low activity response to RF-amide-related peptides (RFRPs), despite the belonging shared family. In contrast, NPFFR1, which shares high sequence similarity with NPFFR2, RFRPs regulates reproductive hormone balance. The molecular basis for these receptor-specific interactions their...
Left-handed Z-DNA is radically different from the most common right-handed B-DNA and can be stabilized by interactions with Zα domain, which found in a group of proteins, such as human ADAR1 viral E3L proteins. It well-known that domains bind to conformation-specific manner induce rapid B-Z transition physiological conditions. Although many structural biochemical studies have identified detailed between domain Z-DNA, little known about molecular basis process. In this study, we successfully...
A quantitative analysis of the decreasing rate monomer and increasing polymerization was made by monitoring radiation level increments using Raman spectroscopy within therapeutic range for a normoxic polymethacrylic acid gel dosimeter. The dosimeter synthesized stirring materials such as gelatin, distilled water, methacrylic acid, hydroquinone tetrakis phosphonium chloride at <TEX>$50^{\circ}C$</TEX>, contained in 10- mm diameter 32-mm high vial to conduct measurement. 24 hours after...