A5021944943- T-cell and Retrovirus Studies
- RNA regulation and disease
- CAR-T cell therapy research
- Advanced Biosensing Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Spondyloarthritis Studies and Treatments
- 3D Printing in Biomedical Research
- Genetics, Aging, and Longevity in Model Organisms
- Virus-based gene therapy research
- Bacteriophages and microbial interactions
- Neuroscience and Neural Engineering
- Electrospun Nanofibers in Biomedical Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced biosensing and bioanalysis techniques
- Ubiquitin and proteasome pathways
- Bone Tissue Engineering Materials
- Immune Cell Function and Interaction
- Force Microscopy Techniques and Applications
- Photoreceptor and optogenetics research
- RNA modifications and cancer
- Bone and Dental Protein Studies
- Cardiovascular Conditions and Treatments
- Terahertz technology and applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Coronary Artery Anomalies
Daegu Gyeongbuk Institute of Science and Technology
2013-2023
Konkuk University
2023
KIST Europe
2008-2014
Korea Institute of Science and Technology
2010-2014
CIBBIM-Nanomedicine
2011
Medical Research Council
2009
MRC Laboratory of Molecular Biology
2005-2008
In this work we present a label free quantitative detection method for DNA samples amplified by polymerase chain reaction (PCR) in aqueous medium using terahertz-time domain spectroscopy (THz-TDS) the frequency range from 0.3 to 1.2 THz. The of 133 and 697 base pairs were prepared PCR. We measured absorption coefficients solutions concentration 0-0.3 ng μl(-1). For both types, decreased with increasing concentrations. average change compared buffer within 0.8-1.0 THz showed linear behavior....
Abstract LMO2 is a transcription regulator involved in human T-cell leukemia, including some occurring X-SCID gene therapy trials, and B-cell lymphomas prostate cancer. functions complexes via protein-protein interactions involving two LIM domains causes preleukemic development blockade followed by clonal tumors. Therefore, necessary but not sufficient for overt neoplasias, which must undergo additional mutations before frank malignancy. An open question the importance of tumor as opposed to...
Titanium-tungsten oxide composites with greatly enhanced photocatalytic activity were synthesized by lysozyme-mediated biomineralization. It was shown for the first time that simple control of onset biomineralization could enable fine tuning composition and crystallinity to determine their performance.
Mouse models of human cancers are important for understanding determinants overt disease and "preclinical" development rational therapeutic strategies; instance, based on macrodrugs. Chromosomal translocations underlie many leukemias, sarcomas, epithelial tumors. We have developed three technologies homologous recombination in mouse ES cells to mimic chromosome translocations. The first, called the knockin method, allows creation fusion genes like those typical leukemias sarcomas. Two new...
The surface adsorption of fd filamentous phage (fd phage) dispersed in different solution pHs was investigated with functionalized SiO2/Si substrates. phages at high pH (∼9.0) were well-adsorbed on the that by 3-aminopropyltriethoxysilane, whereas those low (∼3.0) cleaned surface. affinity carboxylic acid groups (COO−) attributed to fact they give a higher positively charged amine (NH3+) substrate, similar effect H3O+ hydroxyl substrate (OH−). Interestingly, aligned structures intermediate...
Bacteriorhodopsin protein (bR)-based systems are one of the simplest known biological energy converters. The robust chemical, thermal and electrochemical properties bR have made it an attractive material for photoelectric devices. This study demonstrates response a dry layer deposited on nitrocellulose membrane with indium tin oxide (ITO) electrodes. Light-induced electrical current as well potential impedance changes dried film were recorded function illumination. We also tested in solution...
To identify immunoglobulin variable heavy chain (VH) gene usages in Korean ankylosing spondylitis (AS) patients, expression level of VH2 genes from peripheral blood mononuclear cells (PBMCs) 8 AS patients and 9 healthy donors was analysed by quantitative real-time PCR (Q-PCR). Q-PCR results demonstrated were overexpressed (Relative amount mRNA to a house-keeping gene, 7.13 ± 7.77 vs, 0.68 0.55; P < 0.0001). The sequence analysis revealed the majority them contained CDC42 binding protein...
Here, a growth‐factor‐integrated natural extracellular matrix of type I collagen is presented that induces angiogenesis. The developed adapts nanofibers integrated with synthetic colloidal particles recombinant bacteriophages display vascular endothelial growth factor (VEGF). integration achieved during or after gelation the and enables spatial delivery VEGF into desired region. Endothelial cells contact are found to invade form tube‐like structures both in vitro vivo, proving angiogenic...
This paper reports a novel approach for the formation of anti-inflammatory surface coating on neural electrode. The is realized using recombinant f88 filamentous bacteriophage, which displays short platinum binding motif and tumor necrosis factor alpha antagonist (TNF-α antagonist) p3 p8 proteins, respectively. bacteriophages are immobilized by simple dip process. selective stable immobilization electrode confirmed quartz crystal microbalance with dissipation monitoring, atomic force...
Abstract The process of cellular senescence, which is characterized by stable cell cycle arrest, strongly associated with dysfunctional metabolism and circadian rhythmicity, both are reported to result from also be causal senescence. As a result, modifying any them - metabolism, or the clock may affect all three simultaneously. Obesity accelerates aging disrupting homeostasis reactive oxygen species (ROS) via an increased mitochondrial burden fatty acid oxidation. if rhythm linked,...
A 4-year-old mixed breed dog and a 19-year-old English cocker spaniel were evaluated for fecal incontinence. The second dog's incontinence was associated with the anal mass. In both dogs, reconstruction of external sphincter required to gain continence. Especially in an mass, whole musculature involved continence removed affected anorectum. Conventional surgical treatments have limitations terms muscle flap length complexity procedure. modified technique using semitendinosus devised present...
Biological materials with surface-active proteins can be genetically modified to bind target materials. In particular, filamentous-shaped M13 bacteriophages (M13 phage) are attractive scaffolds for functional nanostructures due their highly ordered protein-coat surface. This paper demonstrates a simple method fabricating silica nanocables along phage. The phage was engineered display the amino acid serine on surface provide hydroxyl groups sol-gel reaction. mutant offers homogeneous...
Although various animals have been used as models of cardiac valvular diseases in humans, the structural characteristics valves remain unclear. In this study, we investigated representative animal for purpose comparative anatomy. Adult hearts from three dogs, four goats, six rabbits, and fowls were fixed with 10% neutral-buffered formalin analyzed gross-anatomically. Cardiac appearance was spherical or oval whereas it had a long conical shape fowls. Left atrioventricular (AV) valve composed...
The cover image displays vascular endothelial growth factors (purple and green beads), bacterio-phages (blue rods), their integration on the type 1 collagen extracellular matrix fibers (gray/white fiber bundles). On page 205, C.-H. Nam, S. Chung, co-workers show that of is easy very stable, angiogenesis induced in vitro vivo.
Supplementary Methods from Targeting LMO2 with a Peptide Aptamer Establishes Necessary Function in Overt T-Cell Neoplasia
Supplementary Figure 1 from Targeting LMO2 with a Peptide Aptamer Establishes Necessary Function in Overt T-Cell Neoplasia