A5038612822- Advanced MRI Techniques and Applications
- Multiple Sclerosis Research Studies
- Cerebral Venous Sinus Thrombosis
- Advanced Neuroimaging Techniques and Applications
- Ocular Diseases and Behçet’s Syndrome
- Advanced NMR Techniques and Applications
- RNA regulation and disease
- Glaucoma and retinal disorders
- Hypertrophic osteoarthropathy and related conditions
- Cancer, Lipids, and Metabolism
- Parasitic Infections and Diagnostics
- Ovarian cancer diagnosis and treatment
- Animal Nutrition and Physiology
- Parasitic infections in humans and animals
- Osteomyelitis and Bone Disorders Research
- Hydrogen's biological and therapeutic effects
- Cancer Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Coccidia and coccidiosis research
- Dermatological and Skeletal Disorders
- Chemical Reactions and Isotopes
- Lung Cancer Treatments and Mutations
- Veterinary Oncology Research
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
Swedish Medical Center
2016-2018
Memorial Hospital
2017
Neuroscience Institute
2014
La Jolla Institute For Molecular Medicine
2004
Scripps Research Institute
2004
Institute for Molecular Medicine
2004
University of Edinburgh
2003
Abstract The effects of the pleiotropic serine protease thrombin on tumor cells are commonly thought to be mediated by receptor protease-activated 1 (PAR1). We demonstrate here that PAR1 activation has a role in experimental metastasis using anti-PAR1 antibodies ATAP2 and WEDE15, which block cleavage activation. Thrombin also stimulates chemokinesis human melanoma toward fibroblast conditioned media soluble matrix proteins. Thrombin-enhanced migration is abolished antibodies, demonstrating...
Cancer research depends on the use of human cell lines for both in vitro (culture) and vivo (xenograft) analysis tumor progression treatment. However, extent to which cultured preparations cancer display similar properties , where important host factors may influence biology, remains unclear. Here, we address this question by conducting a functional proteomic breast line MDA-MB-231 grown culture as orthotopic xenograft tumors mammary fad pad immunodeficient mice. Using suite activity-based...
The study purpose was to examine vision-specific and overall health-related quality of life (QOL) at baseline in Idiopathic Intracranial Hypertension Treatment Trial patients who were newly diagnosed had mild visual loss. We also sought determine the associations between QOL scores symptoms, function, pain, headache-related disability, obesity.
To evaluate the clinical utility of fast whole-brain macromolecular proton fraction ( MPF ) mapping in multiple sclerosis MS and compare with established quantitative magnetic resonance (MR) imaging measures tissue damage including magnetization transfer MT ratio relaxation rate (R1).
<h3>Objectives:</h3> Determine potential risk factors for progressive visual field loss in the Idiopathic Intracranial Hypertension Treatment Trial, a randomized placebo-controlled trial of acetazolamide patients with idiopathic intracranial hypertension and mild concurrently receiving low sodium, weight reduction diet. <h3>Methods:</h3> Logistic regression classification tree analyses were used to evaluate protocol-defined treatment failure (>2 dB perimetric mean deviation [PMD] change...
<h3>BACKGROUND AND PURPOSE:</h3> Fast macromolecular proton fraction mapping is a recent quantitative MR imaging method for myelin assessment. The objectives of this study were to evaluate the as measure demyelination in subcortical GM structures multiple sclerosis and assess potential relationship between excess iron deposition using T2* mapping. <h3>MATERIALS METHODS:</h3> Macromolecular maps obtained from 12 healthy controls, 18 patients with relapsing-remitting MS, secondary-progressive...
Myelin containing in basal ganglia multiple sclerosis patients was evaluated using new noninvasive quantitative MRI method fast whole brain macromolecular proton fraction mapping. level globus pallidus and putamen significantly decreased as compared with healthy control subjects but not substantia nigra caudate nucleus.